Targeting neuroinflammation with minocycline in heavy drinkers
Petrakis IL, Ralevski E, Gueorguieva R, Sloan ME, Devine L, Yoon G, Arias AJ, Sofuoglu M. Targeting neuroinflammation with minocycline in heavy drinkers. Psychopharmacology 2019, 236: 3013-3021. PMID: 30919006, PMCID: PMC6764907, DOI: 10.1007/s00213-019-05205-3.Peer-Reviewed Original ResearchConceptsPro-inflammatory cytokine releaseEthanol-induced inflammationMicroglial activationCytokine levelsCytokine releaseHeavy drinkersSecond-generation tetracycline antibioticDose of minocyclinePlacebo-controlled trialSerum cytokine levelsSubjective responsesBaseline cytokine levelsEffects of minocyclineViable treatment strategyShort-term treatmentAlcohol use disorderNeuroimmune modulationMinocycline treatmentNeuroimmune signalingMinocycline effectsIntravenous ethanolEthanol intakeSedative responseTreatment strategiesPreclinical studies