2007
Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia
Gunduz-Bruce H, Szeszko PR, Gueorguieva R, Ashtari M, Robinson DG, Kane JM, Bilder RM. Cortisol levels in relation to hippocampal sub-regions in subjects with first episode schizophrenia. Schizophrenia Research 2007, 94: 281-287. PMID: 17490857, DOI: 10.1016/j.schres.2007.03.025.Peer-Reviewed Original ResearchConceptsFirst-episode schizophreniaHippocampal volumeRegional hippocampal volumesCortisol levelsEpisode schizophreniaAnterior hippocampal volumeDiurnal salivary cortisol levelsSalivary cortisol levelsCoronal MR imagesHigher cortisol levelsCushing's syndromeFirst admissionPatient groupHealthy controlsCortisol exposureHealthy adolescentsSignificant associationSchizophreniaVolumetric reductionCortisol measuresLarge-scale studiesGenetic factorsSchizophrenia sampleSyndromeCortisol
2005
Extracellular metabolites in the cortex and hippocampus of epileptic patients
Cavus I, Kasoff WS, Cassaday MP, Jacob R, Gueorguieva R, Sherwin RS, Krystal JH, Spencer DD, Abi‐Saab W. Extracellular metabolites in the cortex and hippocampus of epileptic patients. Annals Of Neurology 2005, 57: 226-235. PMID: 15668975, DOI: 10.1002/ana.20380.Peer-Reviewed Original ResearchConceptsGlutamate-glutamine cyclingEpileptogenic hippocampusGlutamate levelsEpileptic patientsImpaired glutamate reuptakeBasal glutamate levelsBrain energy metabolismHigher lactate levelsGlutamine/glutamate ratioPoor glucose utilizationEnergy metabolismNeurometabolic processesNonepileptogenic cortexEpileptogenic cortexGlutamate reuptakeNeocortical epilepsyExtracellular glutamateSeizure generationInterictal periodLactate levelsMicrodialysis methodExtracellular levelsNeuronal toxicityGlucose utilizationDepth electrodes