2021
Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans
Angarita GA, Worhunsky PD, Naganawa M, Toyonaga T, Nabulsi NB, Li C, Esterlis I, Skosnik PD, Radhakrishnan R, Pittman B, Gueorguieva R, Potenza MN, Finnema SJ, Huang Y, Carson RE, Malison RT. Lower prefrontal cortical synaptic vesicle binding in cocaine use disorder: An exploratory 11C‐UCB‐J positron emission tomography study in humans. Addiction Biology 2021, 27: e13123. PMID: 34852401, PMCID: PMC8891080, DOI: 10.1111/adb.13123.Peer-Reviewed Original ResearchConceptsCocaine use disorderAnterior cingulate cortexRecent cocaine useSynaptic densityMedial orbitofrontal cortexPrefrontal cortexCocaine useOrbitofrontal cortexUse disordersVentromedial prefrontal cortexPositron emission tomography scanPositron emission tomography studyEmission tomography scanSynaptic vesicle glycoprotein 2AHealthy control subjectsVolume of distributionEmission tomography studiesAcute cocaineControl subjectsTomography scanCocaine exposurePreclinical studiesHC subjectsDendritic spinesLifetime cocaine useDetecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory
Kiluk BD, Roos CR, Aslan M, Gueorguieva R, Nich C, Babuscio TA, Carroll KM. Detecting change in psychiatric functioning in clinical trials for cocaine use disorder: sensitivity of the Addiction Severity Index and Brief Symptom Inventory. Drug And Alcohol Dependence 2021, 228: 109070. PMID: 34600247, PMCID: PMC8595796, DOI: 10.1016/j.drugalcdep.2021.109070.Peer-Reviewed Original ResearchConceptsAddiction Severity IndexGlobal Severity IndexPsychiatric composite scoreClinical trialsCocaine useCocaine use disorderPsychiatric functioningBrief Symptom InventorySeverity IndexUse disordersASI psychiatric composite scoreSymptom InventoryEffect sizeStart of treatmentComposite scoreClinical trial participantsWeek 12Functional outcomeTreatment periodTrial participantsPsychiatric problemsDrug usePotential functional benefitsMedium effect sizeSubstance users
2012
A single-day paradigm of self-regulated human cocaine administration
Matuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration. Pharmacology Biochemistry And Behavior 2012, 103: 95-101. PMID: 22922558, PMCID: PMC3652339, DOI: 10.1016/j.pbb.2012.08.009.Peer-Reviewed Original Research
2009
Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases
Angarita GA, Pittman B, Gueorguieva R, Kalayasiri R, Lynch WJ, Sughondhabirom A, Morgan PT, Malison RT. Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases. Pharmacology Biochemistry And Behavior 2009, 95: 51-55. PMID: 20005893, PMCID: PMC2824073, DOI: 10.1016/j.pbb.2009.12.005.Peer-Reviewed Original Research
2006
Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Lappalainen J, Gelernter J, Cubells JF, Malison RT. Dopamine β-Hydroxylase Gene (DβH) -1021C→T Influences Self-Reported Paranoia during Cocaine Self-Administration. Biological Psychiatry 2006, 61: 1310-1313. PMID: 17157269, DOI: 10.1016/j.biopsych.2006.08.012.Peer-Reviewed Original ResearchA paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial
Lynch WJ, Sughondhabirom A, Pittman B, Gueorguieva R, Kalayasiri R, Joshua D, Morgan P, Coric V, Malison RT. A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial. Psychopharmacology 2006, 185: 306-314. PMID: 16521032, DOI: 10.1007/s00213-006-0323-5.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityCocaine administrationSelf-administered cocaine infusionsCocaine intakeTest-retest componentRegulation of cocaineTiming of infusionAbuse/dependenceDose-dependent fashionFixed ratio 1Non-treatment seeking volunteersDose-dependent wayCocaine abuse/dependenceCurrent studyHuman laboratory modelDrug-induced euphoriaCocaine-taking behaviorHuman cocaine usersCardiovascular responsesHuman laboratory paradigmCocaine infusionsConsecutive daysSubjective effectsPilot studyCocaine usersSelf-reported paranoia during laboratory “binge” cocaine self-administration in humans
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, Cubells JF, Malison RT. Self-reported paranoia during laboratory “binge” cocaine self-administration in humans. Pharmacology Biochemistry And Behavior 2006, 83: 249-256. PMID: 16549106, DOI: 10.1016/j.pbb.2006.02.005.Peer-Reviewed Original ResearchConceptsCocaine-induced paranoiaIntravenous cocaine self-administration sessionsPlacebo-controlled designCocaine self-administration sessionsCocaine-dependent volunteersSelf-administration sessionsTest-retest sessionsCocaine doseHigh dosesCocaine useSignificant main effectDoseDosesSelf-reported paranoiaSubjectsVulnerable subjects
2005
A paradigm to investigate the self-regulation of cocaine administration in humans
Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ, Self D, Jatlow P, Malison RT. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology 2005, 180: 436-446. PMID: 15726333, DOI: 10.1007/s00213-005-2192-8.Peer-Reviewed Original ResearchConceptsCocaine administrationCocaine infusionsEscalating-dose regimenSignificant adverse eventsEffective pharmacological treatmentFixed ratio 1Dose-response relationshipCocaine-taking behaviorAnalgesia methodsAdverse eventsMeasures of cocainePharmacological treatmentNarcotic analgesicsCocaine doseIntravenous cocaineCocaine addictionLess cocaineDrug accessCocaineCocaine usersTest daySignificant main effectInfusionAdministrationSession duration