2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDose
2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responses
2012
A single-day paradigm of self-regulated human cocaine administration
Matuskey D, Pittman B, Chen JI, Wanyiri J, Nadim H, Jatlow P, Gueorguieva R, Potenza MN, Morgan PT, Bhagwagar Z, Malison RT. A single-day paradigm of self-regulated human cocaine administration. Pharmacology Biochemistry And Behavior 2012, 103: 95-101. PMID: 22922558, PMCID: PMC3652339, DOI: 10.1016/j.pbb.2012.08.009.Peer-Reviewed Original Research
2009
Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases
Angarita GA, Pittman B, Gueorguieva R, Kalayasiri R, Lynch WJ, Sughondhabirom A, Morgan PT, Malison RT. Regulation of cocaine self-administration in humans: Lack of evidence for loading and maintenance phases. Pharmacology Biochemistry And Behavior 2009, 95: 51-55. PMID: 20005893, PMCID: PMC2824073, DOI: 10.1016/j.pbb.2009.12.005.Peer-Reviewed Original Research
2006
A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial
Lynch WJ, Sughondhabirom A, Pittman B, Gueorguieva R, Kalayasiri R, Joshua D, Morgan P, Coric V, Malison RT. A paradigm to investigate the regulation of cocaine self-administration in human cocaine users: a randomized trial. Psychopharmacology 2006, 185: 306-314. PMID: 16521032, DOI: 10.1007/s00213-006-0323-5.Peer-Reviewed Original ResearchConceptsTest-retest reliabilityCocaine administrationSelf-administered cocaine infusionsCocaine intakeTest-retest componentRegulation of cocaineTiming of infusionAbuse/dependenceDose-dependent fashionFixed ratio 1Non-treatment seeking volunteersDose-dependent wayCocaine abuse/dependenceCurrent studyHuman laboratory modelDrug-induced euphoriaCocaine-taking behaviorHuman cocaine usersCardiovascular responsesHuman laboratory paradigmCocaine infusionsConsecutive daysSubjective effectsPilot studyCocaine usersSelf-reported paranoia during laboratory “binge” cocaine self-administration in humans
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, Cubells JF, Malison RT. Self-reported paranoia during laboratory “binge” cocaine self-administration in humans. Pharmacology Biochemistry And Behavior 2006, 83: 249-256. PMID: 16549106, DOI: 10.1016/j.pbb.2006.02.005.Peer-Reviewed Original ResearchConceptsCocaine-induced paranoiaIntravenous cocaine self-administration sessionsPlacebo-controlled designCocaine self-administration sessionsCocaine-dependent volunteersSelf-administration sessionsTest-retest sessionsCocaine doseHigh dosesCocaine useSignificant main effectDoseDosesSelf-reported paranoiaSubjectsVulnerable subjects
2005
A paradigm to investigate the self-regulation of cocaine administration in humans
Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ, Self D, Jatlow P, Malison RT. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology 2005, 180: 436-446. PMID: 15726333, DOI: 10.1007/s00213-005-2192-8.Peer-Reviewed Original ResearchConceptsCocaine administrationCocaine infusionsEscalating-dose regimenSignificant adverse eventsEffective pharmacological treatmentFixed ratio 1Dose-response relationshipCocaine-taking behaviorAnalgesia methodsAdverse eventsMeasures of cocainePharmacological treatmentNarcotic analgesicsCocaine doseIntravenous cocaineCocaine addictionLess cocaineDrug accessCocaineCocaine usersTest daySignificant main effectInfusionAdministrationSession duration