2023
Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration
MacLean RR, Eid T, Parida S, Gueorguieva R, DeVito EE, Sofuoglu M. Threshold for the Pleasurable Effects of Nicotine Are Lower Than Its Reinforcing Effects During Self-Administration. Experimental And Clinical Psychopharmacology 2023, 31: 37-45. PMID: 35254839, PMCID: PMC9448824, DOI: 10.1037/pha0000556.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioDose of nicotineNicotine reinforcementSubjective effectsDiscriminative stimulus effectsHeart rate increaseDoses of nicotineSelf-administration procedureSubjective positive effectsDaily smokersBaseline cravingIntravenous nicotineOvernight abstinenceCigarette cravingDrug effectsMetabolite ratiosStimulus effectsSecondary analysisPlaceboSelf-AdministrationNicotine choiceTobacco productsNicotinePleasurable effectsYoung adults
2018
A fMRI study on the impact of advertising for flavored e-cigarettes on susceptible young adults
Garrison KA, O'Malley SS, Gueorguieva R, Krishnan-Sarin S. A fMRI study on the impact of advertising for flavored e-cigarettes on susceptible young adults. Drug And Alcohol Dependence 2018, 186: 233-241. PMID: 29626776, PMCID: PMC5948598, DOI: 10.1016/j.drugalcdep.2018.01.026.Peer-Reviewed Original ResearchConceptsTobacco-flavored e-cigarettesE-cigarettesE-cigarette advertisementsHealth warningsBrain biomarkersWarning labelsYoung adultsSusceptible young adultsE-cigarette health risksE-cigarette conditionsFuture e-cigarette useE-cigarette useFlavored e-cigarettesCigarette conditionCollege-aged young adultsRegular cigarettesNucleus accumbensTobacco productsNucleus accumbens (NAc) activityFMRI studyPositive associationControl imagesHealth risksPoor memoryBiomarkers
2016
Randomized Controlled Trial of a Very Brief, Multicomponent Web-Based Alcohol Intervention for Undergraduates With a Focus on Protective Behavioral Strategies
Leeman RF, DeMartini KS, Gueorguieva R, Nogueira C, Corbin WR, Neighbors C, O’Malley S. Randomized Controlled Trial of a Very Brief, Multicomponent Web-Based Alcohol Intervention for Undergraduates With a Focus on Protective Behavioral Strategies. Journal Of Consulting And Clinical Psychology 2016, 84: 1008-1015. PMID: 27599223, PMCID: PMC5332163, DOI: 10.1037/ccp0000132.Peer-Reviewed Original ResearchConceptsHeavy drinkingWeb-based alcohol interventionPast-month heavy drinkingPeak drinkingControl conditionAlcohol-related problemsBrief interventionAlcohol interventionsYoung adultsInterventionWeeksSignificant differencesDrinkingMonthsDrinksFocused listPBSAssessment controlResearch interventionsFirst studyCondition participants
2015
Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety.
O'Malley SS, Corbin WR, Leeman RF, DeMartini KS, Fucito LM, Ikomi J, Romano DM, Wu R, Toll BA, Sher KJ, Gueorguieva R, Kranzler HR. Reduction of alcohol drinking in young adults by naltrexone: a double-blind, placebo-controlled, randomized clinical trial of efficacy and safety. The Journal Of Clinical Psychiatry 2015, 76: e207-13. PMID: 25742208, PMCID: PMC4442987, DOI: 10.4088/jcp.13m08934.Peer-Reviewed Original ResearchConceptsHeavy drinking daysBlood alcohol concentrationPercent days abstinentDrinking daysNumber of drinksYoung adultsDays abstinentPercent heavy drinking daysOutpatient research centerSafety of naltrexonePlacebo-controlled studySerious adverse eventsRisk-benefit ratioPercentage of daysAdverse eventsSecondary outcomesPrimary outcomeFrequency of drinkingOpioid antagonistAdult heavy drinkersAlcohol drinkingClinical trialsEvaluable samplesYoung adult heavy drinkersTreatment period