2022
Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans
Gueorguieva R, Schwartz EKC, MacLean RR, DeVito EE, Eid T, Wu R, O’Malley S, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker for the Behavioral Effects of Menthol and Nicotine in Humans. Frontiers In Pharmacology 2022, 13: 844824. PMID: 35431934, PMCID: PMC9009207, DOI: 10.3389/fphar.2022.844824.Peer-Reviewed Original ResearchSubjective drug effectsPlasma Mg concentrationHeart rateDrug effectsIntravenous deliveryNon-menthol cigarette smokersPlacebo-controlled studyTest sessionsCigarette smokersMenthol smokersAcute effectsIntravenous nicotineGlucuronide concentrationsMAIN OUTCOMENicotine infusionMenthol glucuronideSecondary analysisPlasma MgE-cigarettesBehavioral effectsMenthol exposureNicotineSmokersPhysiological effectsE-liquids
2018
Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation
Jatlow P, Valentine G, Gueorguieva R, Nadim H, Wu R, O'Malley SS, Sofuoglu M. Plasma Menthol Glucuronide as a Biomarker of Acute Menthol Inhalation. Tobacco Regulatory Science 2018, 4: 586-591. PMID: 29479558, PMCID: PMC5822727, DOI: 10.18001/trs.4.1.5.Peer-Reviewed Original ResearchPlasma Mg concentrationHuman challenge studiesMenthol inhalationMenthol glucuronideMenthol exposureChallenge studiesAnti-irritant effectsDose-dependent increaseInhalation of aerosolsE-cigarette solutionsVenous plasmaVenous bloodIntravenous nicotineNicotine dependenceSecondary analysisInhalationE-cigarettesQuantitative biomarkersVulnerable populationsInter-individual differencesAfrican AmericansNicotineMenthol concentrationGlucuronideBiomarkers