Using Computational Patients to Evaluate Illness Mechanisms in Schizophrenia
Hoffman RE, Grasemann U, Gueorguieva R, Quinlan D, Lane D, Miikkulainen R. Using Computational Patients to Evaluate Illness Mechanisms in Schizophrenia. Biological Psychiatry 2011, 69: 997-1005. PMID: 21397213, PMCID: PMC3105006, DOI: 10.1016/j.biopsych.2010.12.036.Peer-Reviewed Original ResearchConceptsPrediction-error signallingStory recall taskIllness mechanismsEpisodic memoryRecall taskAssociated emotionsNarrative memoryNarrative languageDopamine neuromodulationDisparate symptomsNarrative understandingHealthy control subjectsDisorganized speechMemorySchizoaffective disorderComputational modelNeural network modelParental educationSchizophreniaCrime storiesPrediction errorDelusionsControl subjectsEmotionsNetwork model