2006
Self-reported paranoia during laboratory “binge” cocaine self-administration in humans
Kalayasiri R, Sughondhabirom A, Gueorguieva R, Coric V, Lynch WJ, Morgan PT, Cubells JF, Malison RT. Self-reported paranoia during laboratory “binge” cocaine self-administration in humans. Pharmacology Biochemistry And Behavior 2006, 83: 249-256. PMID: 16549106, DOI: 10.1016/j.pbb.2006.02.005.Peer-Reviewed Original ResearchConceptsCocaine-induced paranoiaIntravenous cocaine self-administration sessionsPlacebo-controlled designCocaine self-administration sessionsCocaine-dependent volunteersSelf-administration sessionsTest-retest sessionsCocaine doseHigh dosesCocaine useSignificant main effectDoseDosesSelf-reported paranoiaSubjectsVulnerable subjects
2005
A paradigm to investigate the self-regulation of cocaine administration in humans
Sughondhabirom A, Jain D, Gueorguieva R, Coric V, Berman R, Lynch WJ, Self D, Jatlow P, Malison RT. A paradigm to investigate the self-regulation of cocaine administration in humans. Psychopharmacology 2005, 180: 436-446. PMID: 15726333, DOI: 10.1007/s00213-005-2192-8.Peer-Reviewed Original ResearchConceptsCocaine administrationCocaine infusionsEscalating-dose regimenSignificant adverse eventsEffective pharmacological treatmentFixed ratio 1Dose-response relationshipCocaine-taking behaviorAnalgesia methodsAdverse eventsMeasures of cocainePharmacological treatmentNarcotic analgesicsCocaine doseIntravenous cocaineCocaine addictionLess cocaineDrug accessCocaineCocaine usersTest daySignificant main effectInfusionAdministrationSession duration