2022
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
2020
Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers
Jensen KP, Valentine G, Gueorguieva R, Sofuoglu M. Differential effects of nicotine delivery rate on subjective drug effects, urges to smoke, heart rate and blood pressure in tobacco smokers. Psychopharmacology 2020, 237: 1359-1369. PMID: 31996940, PMCID: PMC7386792, DOI: 10.1007/s00213-020-05463-6.Peer-Reviewed Original ResearchConceptsSubjective drug effectsBlood pressureHeart rateDrug effectsSmoking urgesDifferential effectsBlood pressure increaseBody weight doseEffects of nicotineDelivery rateGreater heart rateAmount of nicotineWeight doseFemale smokersTobacco smokersAbstinence symptomsNicotine doseSaline infusionInfusion protocolNon-treatment seekingTobacco cigarettesHuman studiesInfusionTobacco productsNicotine
2015
Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences
Jensen KP, DeVito EE, Valentine G, Gueorguieva R, Sofuoglu M. Intravenous Nicotine Self-Administration in Smokers: Dose–Response Function and Sex Differences. Neuropsychopharmacology 2015, 41: 2034-2040. PMID: 26717881, PMCID: PMC4908640, DOI: 10.1038/npp.2015.373.Peer-Reviewed Original ResearchConceptsBlood pressureHeart rateFemale smokersRandomized double-blind crossover designDouble-blind crossover designSubjective effectsTobacco-dependent subjectsSex differencesDiastolic blood pressureIntravenous Nicotine Self-AdministrationSelf-administration ratesNicotine Self-AdministrationDose-response functionNicotine dosesNicotine doseTobacco dependenceIntravenous nicotineCrossover designSelf-AdministrationReinforcement thresholdSmokersInfusionNicotineForced-choice trialsAversive responses