2023
Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology
Syed S, Sinha R, Milivojevic V, MacDougall A, LaValle H, Angarita G, Fox H. Hypothalamic‐pituitary‐adrenal and autonomic response to psychological stress in abstinent alcohol use disorder individuals with and without depressive symptomatology. Human Psychopharmacology Clinical And Experimental 2023, 38: e2867. PMID: 37165544, DOI: 10.1002/hup.2867.Peer-Reviewed Original ResearchConceptsAlcohol use disorderRelapse riskDepressive symptomatologyDepressive symptomsAutonomic responsesIndividual relapse riskChronic alcohol useDepressive pathophysiologyAdrenocorticotropic hormoneInhibitory systemPlasma measuresUse disordersClinical practicePhasic changesConsecutive daysAlcohol usePsychological stressStroop performanceDisorder individualsDrinking controlsSymptomatologyImagery exposureCounterbalanced orderSymptomsDepression
2022
Neural correlates linking trauma and physical symptoms
Choi J, Martins J, Hwang S, Sinha R, Seo D. Neural correlates linking trauma and physical symptoms. Psychiatry Research Neuroimaging 2022, 327: 111560. PMID: 36327865, PMCID: PMC9757618, DOI: 10.1016/j.pscychresns.2022.111560.Peer-Reviewed Original ResearchConceptsPhysical symptomsFunctional magnetic resonance imagingTrauma patientsLateral prefrontal cortexPrefrontal cortexPhysical symptom frequencyPain-related disordersMagnetic resonance imagingNeural correlatesPhysical health symptomsChronic painHealthy controlsTrauma groupSymptom frequencyDorsal striatumGreater physical symptomsSensorimotor areasCurrent studyHippocampal responsesVentromedial prefrontal cortexHealth symptomsHippocampal functionResonance imagingSymptomsUnderlying neurological mechanisms
2013
Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms
Seo D, Tsou KA, Ansell EB, Potenza MN, Sinha R. Cumulative Adversity Sensitizes Neural Response to Acute Stress: Association with Health Symptoms. Neuropsychopharmacology 2013, 39: 670-680. PMID: 24051900, PMCID: PMC3895244, DOI: 10.1038/npp.2013.250.Peer-Reviewed Original ResearchConceptsMedial orbitofrontal cortexAdverse health symptomsStress-induced activityHealth symptomsOrbitofrontal cortexCumulative adversityAcute stressMagnetic resonance imaging resultsAdverse health outcomesNeural responsesCornell Medical IndexFunctional magnetic resonance imaging resultsHigh-Ca groupRight hippocampusRight amygdalaHealthy individualsCA groupHealth outcomesMedical IndexLateral prefrontal cortexSignificant associationSymptomsHealth consequencesPrefrontal cortexTemporal regions