2024
Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study
Puklin L, Irwin M, Sanft T, Ferrucci L, Harrigan M, McGowan C, Cartmel B, Zupa M, Winer E, Deyling M, Ligibel J, Basen-Engquist K, Spiegelman D, Sharifi M. Barriers to and facilitators of improving physical activity and nutrition behaviors during chemotherapy for breast cancer: a sequential mixed methods study. Supportive Care In Cancer 2024, 32: 590. PMID: 39141176, DOI: 10.1007/s00520-024-08789-5.Peer-Reviewed Original ResearchConceptsPhysical activityLifestyle interventionSelf-reported PA questionnaireSelf-reported diet qualityBreast cancerHealthy Eating Index-2015Stage I-III breast cancerBenefits of PASequential mixed methods studyI-III breast cancerChemotherapy-related symptomsMixed methods studyThematic content analysisBehavioral goalsSense of controlBody mass indexPA questionnaireSemi-structured interviewsMean body mass indexTranscribed verbatimIntervention armTailored educationDiet qualityNutritional behaviorMental benefitsImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors
Puklin L, Harrigan M, Cartmel B, Sanft T, Gottlieb L, Zhou B, Ferrucci L, Li F, Spiegelman D, Sharifi M, Irwin M. Randomized Trial Evaluating a Self-Guided Lifestyle Intervention Delivered via Evidence-Based Materials versus a Waitlist Group on Changes in Body Weight, Diet Quality, Physical Activity, and Quality of Life among Breast Cancer Survivors. Cancers 2023, 15: 4719. PMID: 37835412, PMCID: PMC10571774, DOI: 10.3390/cancers15194719.Peer-Reviewed Original ResearchBreast cancer survivorsCancer survivorsLifestyle interventionPhysical activityQuality of lifeBody weightWaitlist groupDiet qualitySelf-reported body weightWeight lossFavorable weight changeHealthy weight lossBody mass indexHealthy body weightGreater weight lossEvidence-based materialsDiverse healthcare settingsIntervention armMass indexClinical practicePositive behavior changeHealthcare settingsSurvivorsWeight changeInterventionDiet and physical activity interventions in Black and Latina women with breast cancer: A scoping review
Pichardo M, Sanft T, Ferrucci L, Romero-Ramos Y, Cartmel B, Harrigan M, Velazquez A, Fayanju O, Winer E, Irwin M. Diet and physical activity interventions in Black and Latina women with breast cancer: A scoping review. Frontiers In Oncology 2023, 13: 1079293. PMID: 36994212, PMCID: PMC10040823, DOI: 10.3389/fonc.2023.1079293.Peer-Reviewed Original ResearchBreast cancer survivorsPhysical activity interventionsLifestyle interventionCancer survivorsActivity interventionsLatina womenEfficacy trialsBreast cancerLatina breast cancer survivorsTrial of dietOne-year followFavorable behavioral changesBreast cancer diagnosisPrimary outcomeAvailable peer-reviewed literatureFuture trialsInformal care giversPilot trialSustained behavior changeEfficacy studiesHealthful lifestyleCare giversTrialsWeight lossCancer diagnosis
2021
The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention
Delahanty LM, Wadden TA, Goodwin PJ, Alfano CM, Thomson CA, Irwin ML, Neuhouser ML, Crane TE, Frank E, Spears PA, Gillis BP, Hershman DL, Paskett ED, Hopkins J, Bernstein V, Stearns V, White J, Hudis C, Winer EP, Carey L, Partridge AH, Ligibel JA. The Breast Cancer Weight Loss trial (Alliance A011401): A description and evidence for the lifestyle intervention. Obesity 2021, 30: 28-38. PMID: 34932888, PMCID: PMC9186690, DOI: 10.1002/oby.23287.Peer-Reviewed Original ResearchConceptsWeight loss interventionWeight loss trialLifestyle interventionHealth education materialsWeight lossLoss trialPhysical activityInvasive disease-free survivalDisease-free survivalBreast cancer patientsBreast cancer diagnosisCare of thousandsEducation materialsBaseline weightCancer outcomesCancer patientsHealth coachesCancer recurrenceBreast cancerCaloric restrictionStage IITrialsCancer diagnosisInterventionWomenDietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions
Harrigan M, McGowan C, Hood A, Ferrucci LM, Nguyen T, Cartmel B, Li FY, Irwin ML, Sanft T. Dietary Supplement Use and Interactions with Tamoxifen and Aromatase Inhibitors in Breast Cancer Survivors Enrolled in Lifestyle Interventions. Nutrients 2021, 13: 3730. PMID: 34835986, PMCID: PMC8621720, DOI: 10.3390/nu13113730.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsDietary supplement useCancer survivorsAromatase inhibitorsSupplement useDietary supplementsEndocrine therapyLifestyle interventionWorld Cancer Research Fund/American InstituteSelf-reported dietary supplement useNatural Medicines databaseAdjuvant endocrine therapyBreast cancer treatmentAdverse interactionsPotential adverse interactionsPharmacodynamic interactionsClinical efficacyCancer preventionHigh prevalenceGeneral populationPotential interactionsMedicine DatabaseTamoxifenCancer treatmentSurvivorsEffect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer
Lisevick A, Cartmel B, Harrigan M, Li F, Sanft T, Fogarasi M, Irwin ML, Ferrucci LM. Effect of the Lifestyle, Exercise, and Nutrition (LEAN) Study on Long-Term Weight Loss Maintenance in Women with Breast Cancer. Nutrients 2021, 13: 3265. PMID: 34579142, PMCID: PMC8469752, DOI: 10.3390/nu13093265.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsLong-term weight loss maintenanceUsual care groupWeight loss maintenanceCancer survivorsStudy completionCare groupLoss maintenanceWeight lossBody weightLong-term weight maintenanceShort-term weight lossLong-term weight gainModest weight lossOverweight/obesityElectronic health recordsLifestyle interventionWeight maintenanceBreast cancerWeight trajectoriesWeight gainCurve analysisNutrition studiesWeight changeHealth recordsImpact of a randomized weight loss trial on breast tissue markers in breast cancer survivors.
Dieli-Conwright C, Harrigan M, Cartmel B, Chagpar A, Bai Y, Rimm D, Pusztai L, Lu L, Sanft T, Irwin M. Impact of a randomized weight loss trial on breast tissue markers in breast cancer survivors. Journal Of Clinical Oncology 2021, 39: e12501-e12501. DOI: 10.1200/jco.2021.39.15_suppl.e12501.Peer-Reviewed Original ResearchBreast cancer survivorsWeight loss interventionSerum insulin levelsCancer survivorsLoss interventionPercent body fatSerum levelsSerum biomarkersTissue biomarkersBody compositionMonth 6Insulin levelsBreast tissueBreast cancerInsulin receptorBody fatStage I breast cancerBreast tissue levelsI breast cancerWeight loss trialBreast tissue markersLevels of CD163Breast tissue biopsiesUsual careLifestyle interventionRandomized trial of weight loss on circulating ghrelin levels among breast cancer survivors
Puklin L, Cartmel B, Harrigan M, Lu L, Li FY, Sanft T, Irwin ML. Randomized trial of weight loss on circulating ghrelin levels among breast cancer survivors. Npj Breast Cancer 2021, 7: 49. PMID: 33976224, PMCID: PMC8113314, DOI: 10.1038/s41523-021-00260-6.Peer-Reviewed Original ResearchBreast cancer survivorsBody mass indexCancer survivorsGhrelin levelsLifestyle interventionUsual careWeight lossPg/Higher ghrelin levelsWeight loss interventionLean body massSix-month changesGreater weight lossWeight regainLoss interventionStudy armsMass indexWeight maintenanceBlood biomarkersHormone ghrelinBlood samplesGhrelinBody compositionBody weightBaseline associationsExamining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention
Nguyen T, Irwin ML, Dewan AT, Cartmel B, Harrigan M, Ferrucci LM, Sanft T, Li F, Lu L, Salinas YD. Examining the effect of obesity-associated gene variants on breast cancer survivors in a randomized weight loss intervention. Breast Cancer Research And Treatment 2021, 187: 487-497. PMID: 33677781, DOI: 10.1007/s10549-021-06151-5.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsUsual care groupWeight loss interventionCancer survivorsLoss interventionCare groupFTO rs9939609Percent body fat changesWeight lossMeaningful weight lossBody fat changesBody mass indexObesity-associated gene FTOObesity-associated gene variantsPercent body fatGreater weight lossLifestyle interventionMass indexTreatment armsIntervention groupBreast cancerBody fatFat changesPurposeOur studyHealthy eatingEfficacy of Weight Loss Interventions in United States Active Duty Military Populations: A Systematic Review
Csizmar G, Irwin M. Efficacy of Weight Loss Interventions in United States Active Duty Military Populations: A Systematic Review. Military Medicine 2021, 186: 1093-1099. PMID: 33506251, DOI: 10.1093/milmed/usab012.Peer-Reviewed Original ResearchConceptsDuty service membersActive duty service membersEfficacy of weight loss interventionsWeight loss interventionService membersSystematic reviewActive duty military populationOverseas contingency operationsElectronic databases PubMedPolicy changesNational securityPolicy effortsFood environmentLifestyle interventionUnderdeveloped researchPrevention effortsMilitary populationDoD leadersInclusion criteriaMeasured outcomesMilitary membersDatabases PubMedTarget populationInterventionMember moves
2008
Impact of Nutrition and Exercise on Cancer Survival
Irwin ML, Mayne ST. Impact of Nutrition and Exercise on Cancer Survival. The Cancer Journal 2008, 14: 435-441. PMID: 19060611, DOI: 10.1097/ppo.0b013e31818daeee.Peer-Reviewed Original ResearchConceptsCancer survivorsSupplement useCancer survivalAdverse prognostic factorPhysical activity recommendationsNutrient supplement useAmerican Cancer SocietyLifestyle-based approachLong-term survivalImpact of nutritionLifestyle interventionPrognostic factorsRandomized trialsCancer outcomesPhysical inactivityActivity recommendationsCurrent guidelinesNumber of menCancer SocietyPhysical activityWeight gainAvailable evidenceSurvivorsSurvivalObesity