2024
Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO)
Schmitz K, Brown J, Irwin M, Robien K, Scott J, Berger N, Caan B, Cercek A, Crane T, Evans S, Ligibel J, Meyerhardt J, Agurs-Collins T, Basen-Engquist K, Bea J, Cai S, Cartmel B, Chinchilli V, Demark-Wahnefried W, Dieli-Conwright C, DiPietro L, Doerksen S, Edelstein S, Elena J, Evans W, Ferrucci L, Foldi J, Freylersythe S, Furberg H, Jones L, Levine R, Moskowitz C, Owusu C, Penedo F, Rabin B, Ratner E, Rosenzweig M, Salz T, Sanft T, Schlumbrecht M, Spielmann G, Thomson C, Tjaden A, Weiser M, Yang S, Yu A, Perna F, Caan B, Anderson S, Bahia H, Castillo A, Feliciano E, Johnson K, Ross M, Weltzein E, Brown J, Albarado B, Compton S, Green T, Nash R, Nauta P, Welch M, Yang S, Meyerhardt J, Dieli-Conwright C, Nguyen D, Pena A, Spielmann G, Kim Y, Evans W, Bea J, Blew R, Crane T, Bhatti A, Clavon R, Erlandsen S, Freylersythe S, Hollander K, Lopez-Pentecost M, Penedo F, Rolle L, Rossi P, Schlumbrecht M, Wheeler M, Irwin M, Cao A, Cartmel B, Ferrucci L, Gottlieb L, Harrigan M, Li F, McGowan C, Puklin L, Ratner E, Sanft T, Zupa M, Berger N, Cerne S, Mills C, Conochan S, Hundal J, Owusu C, Ligibel J, Campbell N, DiGuglielmo K, Kemp W, Maples-Campbell C, Nguyen T, Oppenheim J, Tanasijevic A, Thomson C, Yung A, Basen-Engquist K, Loomba P, Chinchilli V, Schmitz K, Binder J, Doerksen S, Foldi J, Garrett S, Scalise R, Sobolewski M, White L, Scott J, Cercek A, Cai S, Cao S, Furberg H, Harrison J, Jones L, Lee C, Levine R, Michalski M, Moskowitz C, Novo R, Rabazzi J, Stoeckel K, Salz T, Weiser M, Yu A, Demark-Wahnefried W, Robien K, Evans S, DiPietro L, Duong B, Edelstein S, Helmchen L, Le D, McCleary C, Tjaden A, Wopat H, Rabin B, Perna F, Agurs-Collins T, Czajkowski S, Elena J, Nebeling L, Norton W. Exercise and Nutrition to Improve Cancer Treatment-Related Outcomes (ENICTO). Journal Of The National Cancer Institute 2024, djae177. PMID: 39118255, DOI: 10.1093/jnci/djae177.Peer-Reviewed Original ResearchSelf-reported physical functionTreatment-related outcomesTreatment-related side effectsRisk of suboptimal outcomesExercise interventionOncology carePhysical functionNational Cancer InstituteNutrition ProgramIntervention effectsCommon Data ElementsExerciseCancer InstituteCommunity opportunitiesData elementsStandard of careInterventionCareCancer patientsNutritionRelative dose intensityOutcomesSuboptimal outcomesCancer treatmentChemotherapy relative dose intensityImproving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial
Puklin L, Ferrucci L, Harrigan M, McGowan C, Zupa M, Cartmel B, Li F, Ligibel J, Spiegelman D, Sharifi M, Sanft T, Irwin M. Improving lifestyle behaviors during chemotherapy for breast cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis (LEANer) Trial. Cancer 2024, 130: 2440-2452. PMID: 38470431, PMCID: PMC11214600, DOI: 10.1002/cncr.35280.Peer-Reviewed Original ResearchPhysical activityDiet qualityHEI-2015Strength trainingLifestyle behaviorsHealthy Eating Index (HEI)-2015Breast cancerAssociated with baseline fatigueImprove physical activityImprove lifestyle behaviorsHigher HEI-2015Associated with higher oddsExercise interventionUsual careIntervention armIntervention groupBaseline fatigueLifestyle interventionYearlong interventionLower fatigueHigher oddsSecondary analysisLogistic regressionNewly diagnosed patientsStudy arms
2023
Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study
Sanft T, Harrigan M, McGowan C, Cartmel B, Zupa M, Li F, Ferrucci L, Puklin L, Cao A, Nguyen T, Neuhouser M, Hershman D, Basen-Engquist K, Jones B, Knobf T, Chagpar A, Silber A, Tanasijevic A, Ligibel J, Irwin M. Randomized Trial of Exercise and Nutrition on Chemotherapy Completion and Pathologic Complete Response in Women With Breast Cancer: The Lifestyle, Exercise, and Nutrition Early After Diagnosis Study. Journal Of Clinical Oncology 2023, 41: 5285-5295. PMID: 37656930, PMCID: PMC10691793, DOI: 10.1200/jco.23.00871.Peer-Reviewed Original ResearchConceptsRelative dose intensityPathologic complete responseProportion of patientsBreast cancerNeoadjuvant chemotherapyChemotherapy completionComplete responseNutrition interventionsHigher pathologic complete responseHuman epidermal growth factor receptor 2Epidermal growth factor receptor 2Triple-negative breast cancerChemotherapy dose adjustmentsHome-based exerciseGrowth factor receptor 2Breast cancer outcomesEffects of exerciseFactor receptor 2Electronic medical recordsChi-square testUsual careDose intensityExercise interventionDose adjustmentRandomized trialsEffect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Esserman D, Irwin M, Ferrucci L. Effect of Exercise on Chemotherapy-Induced Peripheral Neuropathy Among Patients Treated for Ovarian Cancer. JAMA Network Open 2023, 6: e2326463. PMID: 37526937, PMCID: PMC10394582, DOI: 10.1001/jamanetworkopen.2023.26463.Peer-Reviewed Original ResearchConceptsChemotherapy-induced peripheral neuropathyAerobic exercise interventionAttention control armExercise intervention armExercise interventionOvarian cancerControl armIntervention armSecondary analysisCIPN symptomsPeripheral neuropathyLifestyle StudyTreatment of CIPNModerate-intensity aerobic exerciseStandard oncology careEffects of exerciseSevere adverse effectsBetween-group differencesAmerican Cancer SocietyQuality of lifeAttention controlCIPN severityPrimary outcomeOncology careAerobic exerciseRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomen
2022
Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors
Cao A, Cartmel B, Li F, Gottlieb L, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Irwin M, Ferrucci L. Exercise adherence in a randomized controlled trial of exercise on quality of life in ovarian cancer survivors. Journal Of Cancer Survivorship 2022, 17: 535-543. PMID: 36550261, PMCID: PMC10038915, DOI: 10.1007/s11764-022-01325-6.Peer-Reviewed Original ResearchConceptsOvarian cancer survivorsMin/weekCancer survivorsExercise goalsCancer recurrenceCounseling sessionsSession attendanceExercise adherenceHigher baseline activity levelsWeekly exercise durationTrial of exerciseMean exercise timeVigorous-intensity exerciseBaseline activity levelsQuality of lifeMore counseling sessionsExercise interventionExercise durationWeek exerciseLifestyle StudyExercise timeOvarian cancerNumber of sessionsCounseling intensitySurvivorsEffect of exercise on body composition among women with ovarian cancer
Cao A, Cartmel B, Li FY, Gottlieb LT, Harrigan M, Ligibel JA, Gogoi R, Schwartz PE, Irwin ML, Ferrucci LM. Effect of exercise on body composition among women with ovarian cancer. Journal Of Cancer Survivorship 2022, 17: 1386-1396. PMID: 35377104, PMCID: PMC9530065, DOI: 10.1007/s11764-022-01207-x.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryOvarian cancer survivorsAerobic exercise interventionEffects of exerciseCancer survivorsOvarian cancerExercise interventionBody compositionSix-month aerobic exercise interventionBone mineral densityBetween-group differencesBody fat percentageLean body massX-ray absorptiometrySecondary outcomesStudy armsAerobic exerciseLifestyle StudyMineral densityHigh riskCancerSurvivorsFat percentageWomenResultsOn averageEffect of Exercise on Sarcopenia among Cancer Survivors: A Systematic Review
Cao A, Ferrucci LM, Caan BJ, Irwin ML. Effect of Exercise on Sarcopenia among Cancer Survivors: A Systematic Review. Cancers 2022, 14: 786. PMID: 35159052, PMCID: PMC8833677, DOI: 10.3390/cancers14030786.Peer-Reviewed Original Research
2020
Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes
Xiao C, Beitler JJ, Higgins KA, Chico CE, Withycombe JS, Zhu Y, Zhao H, Lin IH, Li F, Jeon S, Irwin M, Bruner DW, Miller AH, Gary R. Pilot study of combined aerobic and resistance exercise on fatigue for patients with head and neck cancer: Inflammatory and epigenetic changes. Brain Behavior And Immunity 2020, 88: 184-192. PMID: 32330594, PMCID: PMC7415514, DOI: 10.1016/j.bbi.2020.04.044.Peer-Reviewed Original ResearchConceptsExercise groupInflammatory markersChair standNeck cancerBiceps curlSoluble TNF receptor IIMultidimensional Fatigue Inventory-20Tumor necrosis factor αPilot studyResistance exercise interventionTNF receptor IIPlasma interleukin-6Anti-inflammatory effectsC-reactive proteinPhysical function measuresIL1 receptor antagonistHand grip strengthNecrosis factor αIntensity-modulated radiotherapyStandard careExercise interventionWalk distanceRadiotherapy regimenHNC patientsMean age
2019
Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data.
VAN Vulpen JK, Sweegers MG, Peeters PHM, Courneya KS, Newton RU, Aaronson NK, Jacobsen PB, Galvão DA, Chinapaw MJ, Steindorf K, Irwin ML, Stuiver MM, Hayes S, Griffith KA, Mesters I, Knoop H, Goedendorp MM, Mutrie N, Daley AJ, McConnachie A, Bohus M, Thorsen L, Schulz KH, Short CE, James EL, Plotnikoff RC, Schmidt ME, Ulrich CM, VAN Beurden M, Oldenburg HS, Sonke GS, VAN Harten WH, Schmitz KH, Winters-Stone KM, Velthuis MJ, Taaffe DR, VAN Mechelen W, Kersten MJ, Nollet F, Wenzel J, Wiskemann J, Verdonck-DE Leeuw IM, Brug J, May AM, Buffart LM. Moderators of Exercise Effects on Cancer-related Fatigue: A Meta-analysis of Individual Patient Data. Medicine & Science In Sports & Exercise 2019, 52: 303-314. PMID: 31524827, PMCID: PMC6962544, DOI: 10.1249/mss.0000000000002154.Peer-Reviewed Original ResearchConceptsIndividual patient dataCancer-related fatigueExercise interventionSignificant beneficial effectPatient dataClinical characteristicsSupervised interventionBeneficial effectsClustering of patientsExercise intervention effectsExercise RCTsBaseline fatigueExercise effectsGroup allocationClinical practiceMeta-AnalysisLinear mixed-effects modelsIntervention effectsPatientsMixed-effects modelsLonger durationInterventionRandom interceptDifferential effectsEvidence of moderation
2016
Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer.
Ligibel J, Giobbie-Hurder A, Shockro L, Rhei E, Troyan S, Dominici L, Chagpar A, Frank E, McTiernan A, Yung R, Freedman R, Tolaney S, O'Connor K, Stecker K, Dillon D, Irwin M. Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer. Journal Of Clinical Oncology 2016, 34: 564-564. DOI: 10.1200/jco.2016.34.15_suppl.564.Peer-Reviewed Original Research
2012
Benefits of Aerobic and Resistance Exercise for Cancer Survivors
Irwin M. Benefits of Aerobic and Resistance Exercise for Cancer Survivors. Energy Balance And Cancer 2012, 199-214. DOI: 10.1007/978-1-4614-4493-0_12.Peer-Reviewed Original ResearchCancer outcomesPhysical activityCancer survivorsResistance exerciseSpecific cancer outcomesCancer diagnosisBenefits of exerciseQuality of lifeDiagnosis of cancerFuture exercise interventionsExercise interventionPhysical functioningLower riskSide effectsMore effective strategiesDiagnosisOutcomesExerciseCancerSurvivorsOverall qualitySurgeryRecurrenceEffective strategyActivityPost diagnosis weight gain and the role of exercise in breast cancer survivors.
Sanft T, Alvarez-Reeves M, Irwin M. Post diagnosis weight gain and the role of exercise in breast cancer survivors. Journal Of Clinical Oncology 2012, 30: 9007-9007. DOI: 10.1200/jco.2012.30.15_suppl.9007.Peer-Reviewed Original ResearchBone mineral densityLean body massDual-energy X-ray absorptiometryBreast cancer survivorsUsual careCA survivorsObese womenCancer survivorsBody fatBody compositionPoor breast cancer outcomesWeight gainFavorable body composition changesNon-obese womenBreast cancer outcomesRole of exerciseEffects of exerciseMin/wkPhysical activity levelsBody composition changesX-ray absorptiometrySupervised exerciseExercise groupExercise interventionUC group
2010
Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial
Friedenreich C, Woolcott C, McTiernan A, Terry T, Brant R, Ballard-Barbash R, Irwin M, Jones C, Boyd N, Yaffe M, Campbell K, McNeely M, Karvinen K, Courneya K. Adiposity changes after a 1-year aerobic exercise intervention among postmenopausal women: a randomized controlled trial. International Journal Of Obesity 2010, 35: 427-435. PMID: 20820172, PMCID: PMC3061001, DOI: 10.1038/ijo.2010.147.Peer-Reviewed Original ResearchConceptsAerobic exercise interventionTotal body fatExercise interventionPostmenopausal womenFat areaBody fatGreater body fat lossSubcutaneous abdominal fat areaCurrent public health guidelinesIntra-abdominal fat areaSedentary postmenopausal womenAbdominal fat areaAerobic exercise programExercise five timesBody fat lossDual-energy X-ray absorptiometry measurementsBreast cancer riskVolume of exerciseMeasures of adiposityPublic health guidelinesComputerized tomography measurementsExercise groupObese womenAbdominal adiposityExercise program
2009
Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study
Irwin ML, Varma K, Alvarez-Reeves M, Cadmus L, Wiley A, Chung GG, DiPietro L, Mayne ST, Yu H. Randomized Controlled Trial of Aerobic Exercise on Insulin and Insulin-like Growth Factors in Breast Cancer Survivors: The Yale Exercise and Survivorship Study. Cancer Epidemiology Biomarkers & Prevention 2009, 18: 306-313. PMID: 19124513, PMCID: PMC2841479, DOI: 10.1158/1055-9965.epi-08-0531.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsPostmenopausal breast cancer survivorsModerate-intensity aerobic exerciseUsual care groupBreast cancer riskAerobic exerciseIGFBP-3Cancer survivorsUsual careCare groupCancer riskYale-New Haven Hospital Tumor RegistryCurrent physical activity levelsInsulin-like growth factorHospital tumor registryUsual care participantsAerobic exercise interventionExercise-induced decreasePhysical activity levelsInsulin-like growthExercise groupExercise interventionControlled TrialsTumor RegistryBrisk walking