2024
1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial
Ligibel J, Ballman K, mccall L, Goodwin P, Weiss A, Crane T, Irwin M, Thomson C, Hahn O, Spears P, Hershman D, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Winer E, Carey L, Partridge A. 1817MO Effect of a weight loss intervention (WLI) on exercise behaviors in women with breast cancer: Results from the breast cancer weight loss (BWEL) trial. Annals Of Oncology 2024, 35: s1078. DOI: 10.1016/j.annonc.2024.08.1913.Peer-Reviewed Original ResearchEffects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial
Brown J, Spielmann G, Yang S, Compton S, Jones L, Irwin M, Ligibel J, Meyerhardt J. Effects of exercise or metformin on myokine concentrations in patients with breast and colorectal cancer: A phase II multi‐centre factorial randomized trial. Journal Of Cachexia Sarcopenia And Muscle 2024, 15: 1520-1527. PMID: 38887915, PMCID: PMC11294014, DOI: 10.1002/jcsm.13509.Peer-Reviewed Original ResearchAerobic exerciseMyokine concentrationsStage I-III breastColorectal cancer survivorsEffects of exerciseColorectal cancerLinear mixed-effects regression modelsMixed-effects regression modelsCancer survivorsPhysical activityType I error rateExerciseMyokinesPilot studyRegression modelsCancer patientsRandomized trialsHypothesis-generating analysisMultiple comparisonsBreastSkeletal muscleInterleukin-15Clinical outcomesCancerPatients
2023
Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review.
Pichardo M, Ferrucci L, Molina Y, Esserman D, Irwin M. Structural Racism, Lifestyle Behaviors, and Obesity-related Cancers among Black and Hispanic/Latino Adults in the United States: A Narrative Review. Cancer Epidemiology Biomarkers & Prevention 2023, 32: 1498-1507. PMID: 37650844, PMCID: PMC10872641, DOI: 10.1158/1055-9965.epi-22-1147.Peer-Reviewed Original ResearchConceptsHispanic/Latino adultsObesity-related cancersLifestyle behaviorsLatino adultsLifestyle guidelinesCancer preventionPoor lifestyle behaviorsU.S. Hispanic/Latino adultsHealthful lifestyle behaviorsCause of deathHealthy lifestyle choicesChronic diseasesCardiovascular diseaseCommon causeCancer riskNarrative reviewBlack adultsDisproportionate burdenObesityCancerAdultsLifestyle choicesDiseasePreventionDeathLongitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer
Huang S, Zhan Y, Jeon S, Bruner D, Miller A, Felger J, Wommack E, Saba N, Higgins K, Irwin M, Gary R, Xiao C. Longitudinal associations among physical activity, inflammatory markers, and quality of life in patients with head and neck cancer. Head & Neck 2023, 45: 1952-1966. PMID: 37288586, PMCID: PMC10330673, DOI: 10.1002/hed.27420.Peer-Reviewed Original ResearchConceptsPhysical activityInflammatory markersQuality of lifeLower inflammationNeck cancerTotal QOL scoreHigh physical activityObservational longitudinal studyInactive patientsQOL scoresActive patientsStrength exercisesPatientsInflammationLongitudinal associationsMixed effects modelsSTNFR2Longitudinal studyCancerMarkersAssociationMore researchSubject correlationLow levelsPostradiotherapyRandomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer
Cartmel B, Li F, Zhou Y, Gottlieb L, Lu L, Mszar R, Harrigan M, Ligibel J, Gogoi R, Schwartz P, Risch H, Irwin M. Randomized trial of exercise on cancer‐related blood biomarkers and survival in women with ovarian cancer. Cancer Medicine 2023, 12: 15492-15503. PMID: 37269192, PMCID: PMC10417064, DOI: 10.1002/cam4.6187.Peer-Reviewed Original ResearchConceptsExercise interventionOvarian cancerTrial of exerciseExercise-induced changesMin/weekGroup differencesSubset of participantsCause mortalityExercise groupOverall survivalStudy armsCA 125Randomized trialsBlood biomarkersBlood drawBreast cancerClinical significanceIGF-1Effect model analysisSecondary analysisBeneficial effectsCancerBiomarkersTrialsWomenA review of the impact of energy balance on triple-negative breast cancer
Akingbesote N, Owusu D, Liu R, Cartmel B, Ferrucci L, Zupa M, Lustberg M, Sanft T, Blenman K, Irwin M, Perry R. A review of the impact of energy balance on triple-negative breast cancer. JNCI Monographs 2023, 2023: 104-124. PMID: 37139977, DOI: 10.1093/jncimonographs/lgad011.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTriple-negative breast cancerInterventional studyBreast cancerCancer treatmentClinical interventional studyClinical observationalImmune activationCancer outcomesCancer careClinical studiesOverall healthEnergy intakeNarrative reviewCancer cellsEnergy expenditureCancerTreatmentEnergy balanceOutcomesExerciseReviewDetrimental effectsImmunotherapyStudyIntakeKey takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022
Kung C, Skiba M, Crosby E, Gorzelitz J, Kennedy M, Kerr B, Li Y, Nash S, Potiaumpai M, Kleckner A, James D, Coleman M, Fairman C, Galván G, Garcia D, Gordon M, His M, Hornbuckle L, Kim S, Kim T, Kumar A, Mahé M, McDonnell K, Moore J, Oh S, Sun X, Irwin M. Key takeaways for knowledge expansion of early-career scientists conducting Transdisciplinary Research in Energetics and Cancer (TREC): a report from the TREC Training Workshop 2022. JNCI Monographs 2023, 2023: 149-157. PMID: 37139978, PMCID: PMC10157760, DOI: 10.1093/jncimonographs/lgad005.Peer-Reviewed Original ResearchTranslating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer
Garcia M, Schadler K, Chandra J, Clinton S, Courneya K, Cruz‐Monserrate Z, Daniel C, Dannenberg A, Demark‐Wahnefried W, Dewhirst M, Fabian C, Hursting S, Irwin M, Iyengar N, McQuade J, Schmitz K, Basen‐Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal‐human studies in cancer. CA A Cancer Journal For Clinicians 2023, 73: 425-442. PMID: 36825928, PMCID: PMC11225601, DOI: 10.3322/caac.21773.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsParallel studyHealthy survivorshipCancer outcomesDietary intakePhysical activityAnimal modelsClinical observationsAnimal studiesBody compositionCancer developmentPractice changeCancerPopulation studiesCancer researchEnergy balance researchEnergy balancePatientsSubstantial benefitsClinicStudyIntakeIn silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer
Lu L, Ma W, Johnson C, Khan S, Irwin M, Pusztai L. In silico designed mRNA vaccines targeting CA-125 neoantigen in breast and ovarian cancer. Vaccine 2023, 41: 2073-2083. PMID: 36813666, PMCID: PMC10064809, DOI: 10.1016/j.vaccine.2023.02.048.Peer-Reviewed Original ResearchConceptsMRNA vaccinesOvarian cancerT cell responsesMutation-derived neoantigensT cell epitopesSARS-CoV-2Multiple neoantigensCytotoxic CD8Dendritic cellsCA 125Cancer vaccinesPatient survivalImmune responseCell epitopesNeoepitope peptidesNeoantigensVaccineCell responsesCancerBreastReverse vaccinologyCD8CD40LIFNNeoepitopesA qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers
Pichardo M, Irwin M, Sanft T, Ferrucci L, Ginader A, Nguyen T, Esserman D, Cartmel B, Molina Y. A qualitative study identifying challenges resulting from complex evidence on lifestyle factors and cancer: perspectives from Black and Latina cancer survivors and healthcare providers. Supportive Care In Cancer 2023, 31: 111. PMID: 36633678, PMCID: PMC9912693, DOI: 10.1007/s00520-022-07539-9.Peer-Reviewed Original ResearchConceptsBreast cancer survivorsOncology healthcare providersCancer survivorsLifestyle behaviorsHealthcare providersGeneric messagingEvidence-based knowledgeFemale breast cancer survivorsHealthcare provider counselingHealthy lifestyle guidelinesPatient-level barriersHealthy lifestyle behaviorsLifestyle guidelinesProvider counselingLifestyle factorsOncology careCancer outcomesBreast cancerConsistency of evidenceCurrent evidenceAvailable evidenceSurvivorsCancer diagnosisLevel barriersCancer
2022
Transdisciplinary research in energetics and cancer (TREC) training program for early career investigators.
Irwin M, Lowry D, Neuhouser M, Henry C, Sears D, Schmitz K, Nebeling L, Ligibel J. Transdisciplinary research in energetics and cancer (TREC) training program for early career investigators. Journal Of Clinical Oncology 2022, 40: 11031-11031. DOI: 10.1200/jco.2022.40.16_suppl.11031.Peer-Reviewed Original ResearchCancer incidencePrevalence of obesityCancer researchLower cancer incidenceEarly career investigatorsCancer control continuumTraining programEvidence-based approachPeer-reviewed journalsCancer survivorsPhysical inactivityRisk factorsClinical carePoor dietMortality rateNCI supportPatient careSenior authorOne weekControl continuumCancerPrevalenceIncidencePrincipal investigatorTraining sessionsEffect of exercise on body composition among women with ovarian cancer
Cao A, Cartmel B, Li FY, Gottlieb LT, Harrigan M, Ligibel JA, Gogoi R, Schwartz PE, Irwin ML, Ferrucci LM. Effect of exercise on body composition among women with ovarian cancer. Journal Of Cancer Survivorship 2022, 17: 1386-1396. PMID: 35377104, PMCID: PMC9530065, DOI: 10.1007/s11764-022-01207-x.Peer-Reviewed Original ResearchConceptsDual-energy X-ray absorptiometryOvarian cancer survivorsAerobic exercise interventionEffects of exerciseCancer survivorsOvarian cancerExercise interventionBody compositionSix-month aerobic exercise interventionBone mineral densityBetween-group differencesBody fat percentageLean body massX-ray absorptiometrySecondary outcomesStudy armsAerobic exerciseLifestyle StudyMineral densityHigh riskCancerSurvivorsFat percentageWomenResultsOn averageMarital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance)
Lee S, Ma C, Zhang S, Ou FS, Bainter TM, Niedzwiecki D, Saltz LB, Mayer RJ, Whittom R, Hantel A, Benson A, Atienza D, Kindler H, Gross CP, Irwin ML, Meyerhardt JA, Fuchs CS. Marital Status, Living Arrangement, and Cancer Recurrence and Survival in Patients with Stage III Colon Cancer: Findings from CALGB 89803 (Alliance). The Oncologist 2022, 27: e494-e505. PMID: 35641198, PMCID: PMC9177101, DOI: 10.1093/oncolo/oyab070.Peer-Reviewed Original ResearchConceptsStage III colon cancerRecurrence-free survivalOverall survivalColon cancerCALGB 89803Marital statusAdjuvant chemotherapy trialsColorectal cancer outcomesColon cancer mortalityTime of enrollmentLiving arrangementsChemotherapy trialsSocial support servicesSurvival outcomesCancer mortalityPatient populationCancer outcomesClinical trialsSpouse/partnerWorse outcomesCancer recurrenceNursing homesPatientsSecondary analysisCancer
2021
Exploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery
Knoerl R, Giobbie-Hurder A, Sannes TS, Chagpar AB, Dillon D, Dominici LS, Frank ES, Golshan M, McTiernan A, Rhei E, Tolaney SM, Winer EP, Yung RL, Irwin ML, Ligibel JA. Exploring the impact of exercise and mind–body prehabilitation interventions on physical and psychological outcomes in women undergoing breast cancer surgery. Supportive Care In Cancer 2021, 30: 2027-2036. PMID: 34648061, DOI: 10.1007/s00520-021-06617-8.Peer-Reviewed Original ResearchConceptsCancer treatment-related symptomsPrehabilitation interventionsTreatment-related symptomsTime of enrollmentImpact of exerciseQuality of lifeBreast cancerGroup participantsPre-operative exerciseBreast cancer surgeryMind-body interventionsCognitive functioningOpportunity trialCancer surgeryOutcome measuresSecondary analysisOne monthSurgeryMeasures of qualityGroup comparisonsCancer diagnosisCancerWomenInterventionSignificant differences
2020
Transdisciplinary Research in Energetics and Cancer early career investigator training program: first year results
Irwin ML, Lowry D, Neuhouser ML, Ligibel J, Schmitz K, Patterson RE, Colditz G, Li F, Nebeling L. Transdisciplinary Research in Energetics and Cancer early career investigator training program: first year results. Translational Behavioral Medicine 2020, 11: 549-562. PMID: 32065834, PMCID: PMC7963289, DOI: 10.1093/tbm/ibaa009.Peer-Reviewed Original ResearchConceptsYear of mentorshipYear 1 participantsEarly career investigatorsCancer burdenCancer riskHealth of populationsMentorship periodTraining programProgram satisfactionGroup sessionsCancer researchSmall group sessionsYear resultsFirst year resultsRiskEnergy imbalanceProgram impactFifth yearCourseInvestigatorsSessionsFellowsYearsCancerMortality
2018
The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401).
Ligibel J, Barry W, Alfano C, Hershman D, Irwin M, Neuhouser M, Thomson C, Delahanty L, Frank E, Spears P, Paskett E, Hopkins J, Bernstein V, Stearns V, White J, Wadden T, Goodwin P, Carey L, Partridge A, Winer E. The Breast Cancer Weight Loss (BWEL) trial: Randomized phase III trial evaluating the role of weight loss in adjuvant treatment of overweight and obese women with early-stage breast cancer (Alliance A011401). Journal Of Clinical Oncology 2018, 36: tps598-tps598. DOI: 10.1200/jco.2018.36.15_suppl.tps598.Peer-Reviewed Original Research
2016
Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer.
Ligibel J, Giobbie-Hurder A, Shockro L, Rhei E, Troyan S, Dominici L, Chagpar A, Frank E, McTiernan A, Yung R, Freedman R, Tolaney S, O'Connor K, Stecker K, Dillon D, Irwin M. Impact of a pre-operative exercise intervention on Ki-67 and metabolic markers in women with early breast cancer. Journal Of Clinical Oncology 2016, 34: 564-564. DOI: 10.1200/jco.2016.34.15_suppl.564.Peer-Reviewed Original Research
2014
Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative
Zhou Y, Chlebowski R, LaMonte MJ, Bea JW, Qi L, Wallace R, Lavasani S, Walsh BW, Anderson G, Vitolins M, Sarto G, Irwin ML. Body mass index, physical activity, and mortality in women diagnosed with ovarian cancer: Results from the Women's Health Initiative. Gynecologic Oncology 2014, 133: 4-10. PMID: 24680584, PMCID: PMC4064800, DOI: 10.1016/j.ygyno.2014.01.033.Peer-Reviewed Original ResearchConceptsWomen's Health InitiativeBody mass indexVigorous-intensity physical activityOvarian cancerPhysical activityHealth initiativesLower riskCause mortalityMass indexSelf-reported physical activityOvarian cancer mortalityModifiable lifestyle factorsProportional hazards regressionPrimary ovarian cancerOvarian cancer diagnosisPostmenopausal womenBaseline visitHazards regressionLifestyle factorsCancer mortalityMortality endpointsSurvival rateMortalityCancerCancer diagnosis
2012
Benefits of Aerobic and Resistance Exercise for Cancer Survivors
Irwin M. Benefits of Aerobic and Resistance Exercise for Cancer Survivors. Energy Balance And Cancer 2012, 199-214. DOI: 10.1007/978-1-4614-4493-0_12.Peer-Reviewed Original ResearchCancer outcomesPhysical activityCancer survivorsResistance exerciseSpecific cancer outcomesCancer diagnosisBenefits of exerciseQuality of lifeDiagnosis of cancerFuture exercise interventionsExercise interventionPhysical functioningLower riskSide effectsMore effective strategiesDiagnosisOutcomesExerciseCancerSurvivorsOverall qualitySurgeryRecurrenceEffective strategyActivity
2011
Obesity and Cancer: Epidemiology
Irwin M. Obesity and Cancer: Epidemiology. Energy Balance And Cancer 2011, 1: 101-110. DOI: 10.1007/978-1-4419-9911-5_4.Peer-Reviewed Original Research