Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction
Bayer H, Hassell J, Oleksiak C, Garcia G, Vaughan H, Juliano V, Maren S. Pharmacological stimulation of infralimbic cortex after fear conditioning facilitates subsequent fear extinction. Neuropsychopharmacology 2024, 49: 1951-1957. PMID: 39138373, PMCID: PMC11480363, DOI: 10.1038/s41386-024-01961-9.Peer-Reviewed Original ResearchMedial prefrontal cortexFear conditioningConditioned freezingConditioned stimulusExtinction of conditioned fear memoryConsolidation of fear conditioningExtinction of conditioned fearAuditory conditioned stimulusConditioned fear memoryGABAA receptor antagonistExtinction trainingExtinction learningPicrotoxin infusionConditioned fearFear extinctionInfralimbic cortexPrefrontal cortexFear suppressionInhibitory memoryFear memoryExtinction retrievalPicrotoxin injectionNeuronal plasticityFemale ratsReceptor antagonistNeural circuits for the adaptive regulation of fear and extinction memory
Plas S, Tuna T, Bayer H, Juliano V, Sweck S, Perez A, Hassell J, Maren S. Neural circuits for the adaptive regulation of fear and extinction memory. Frontiers In Behavioral Neuroscience 2024, 18: 1352797. PMID: 38370858, PMCID: PMC10869525, DOI: 10.3389/fnbeh.2024.1352797.Peer-Reviewed Original ResearchRegulation of fearExtinction learningExtinction memoryFear memoryNeural mechanismsExtinction of Pavlovian fear conditioningRegulation of fear memoryNeural circuitsPrefrontal-hippocampal interactionsMedial prefrontal cortexExposure-based therapyPavlovian fear conditioningThalamic nucleus reuniensStress-related disordersEffects of stressPrefrontal cortexFear conditioningContextual controlNucleus reuniensAdaptive behaviorAdaptive regulationClinical implicationsMemoryRodent modelsPharmacological interventions