Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity.
Niemeyer C, Merle L, Bubak A, Baxter B, Gentile Polese A, Colon-Reyes K, Vang S, Hassell J, Bruce K, Nagel M, Restrepo D. Olfactory and trigeminal routes of HSV-1 CNS infection with regional microglial heterogeneity. Journal Of Virology 2024, e0096824. PMID: 39475273, DOI: 10.1128/jvi.00968-24.Peer-Reviewed Original ResearchCentral nervous systemHerpes simplex virus type 1Trigeminal ganglionVirus type 1Olfactory epitheliumHSV-1Locus coeruleusHSV-1 CNS infectionBrain regionsImmune responseResponse to HSV-1Microglial activationType 1Spread of HSV-1Absence of viral antigenHSV-1 antigenHSV-1 spreadHSV-1 infectionC57BL/6 mouse modelCranial nerve nucleiResponse of macrophagesInflammatory response of macrophagesCNS infectionRaphe nucleusNasal epithelia