2023
Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease
Ghosh S, Baker L, Chen F, Khera Z, Vain A, Zhang K, Hood A, Smith H, Chen H, Jagasia M, Tkaczyk E. Interrater reproducibility of the Myoton and durometer devices to quantify sclerotic chronic graft-versus-host disease. Archives Of Dermatological Research 2023, 315: 2545-2554. PMID: 37227518, DOI: 10.1007/s00403-023-02626-1.Peer-Reviewed Original ResearchConceptsSkin sclerosisChronic graftHost diseaseAnatomic sitesAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationSclerotic chronic graftLong-term survivorsStem cell transplantationConfidence intervalsCGVHD treatmentSclerotic cGvHDSevere complicationsSkin scoreCurrent gold standardCell transplantationTherapeutic responseClinical reproducibilityCGVHDDorsal forearmMyotonSclerosisVolar forearmHealthy participantsMean pairwise differenceHyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft‐versus‐host disease
Saknite I, Kwun S, Zhang K, Hood A, Chen F, Kangas L, Kortteisto P, Kukkonen A, Spigulis J, Tkaczyk E. Hyperspectral imaging to accurately segment skin erythema and hyperpigmentation in cutaneous chronic graft‐versus‐host disease. Journal Of Biophotonics 2023, 16: e202300009. PMID: 36942511, DOI: 10.1002/jbio.202300009.Peer-Reviewed Original Research
2022
Artificial intelligence recognition of cutaneous chronic graft‐versus‐host disease by a deep learning neural network
McNeil A, Parks K, Liu X, Saknite I, Chen F, Reasat T, Cronin A, Wheless L, Dawant B, Tkaczyk E. Artificial intelligence recognition of cutaneous chronic graft‐versus‐host disease by a deep learning neural network. British Journal Of Haematology 2022, 197: e69-e72. PMID: 35322873, PMCID: PMC9197858, DOI: 10.1111/bjh.18141.Peer-Reviewed Original Research
2021
Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease
Baker L, Chen F, Cronin A, Chen H, Vain A, Jagasia M, Tkaczyk E. Optimal Biomechanical Parameters for Measuring Sclerotic Chronic Graft-Versus-Host Disease. JID Innovations 2021, 1: 100037. PMID: 34790906, PMCID: PMC8594905, DOI: 10.1016/j.xjidi.2021.100037.Peer-Reviewed Original ResearchCGVHD patientsBiomechanical parametersChronic Graft-VersusSclerotic chronic graftHost disease patientsBackward stepwise selectionChronic graftGraft-VersusSclerotic cGvHDHost diseaseUnivariable analysisTransplant controlsDisease patientsAnatomic sitesPatientsDisease severityLogistic regressionSclerotic diseaseBiomechanical studyDiscriminatory abilityLASSO regressionCharacteristic curveMyotonometerStepwise selectionDiseaseDifferentiation of erythematous and post-inflammatory pigment changes in cutaneous chronic graft-versus-host disease by hyperspectral imaging
Saknīte I, Kwun S, Liu X, Zhang K, Hood A, Chen F, Kangas L, Kukkonen A, Kortteisto P, Byrne M, Jagasia M, Tkaczyk E. Differentiation of erythematous and post-inflammatory pigment changes in cutaneous chronic graft-versus-host disease by hyperspectral imaging. 2021, 15. DOI: 10.1117/12.2578532.Peer-Reviewed Original Research
2020
Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease
Baker LX, Chen F, Ssempijja Y, Byrne M, Kim TK, Vain A, Jagasia M, Tkaczyk ER. Longitudinal tracking of skin dynamic stiffness to quantify evolution of sclerosis in chronic graft-versus-host disease. Bone Marrow Transplantation 2020, 56: 989-991. PMID: 33279941, PMCID: PMC8117134, DOI: 10.1038/s41409-020-01158-w.Peer-Reviewed Original Research18038 Reproducibility of Myoton and durometer devices to quantify skin stiffness and hardness in sclerotic chronic graft-versus-host disease
Wang L, Chen F, Vain A, Ssempijja Y, Dellalana L, Zhang K, Hood A, Chen H, Jagasia M, Tkaczyk E. 18038 Reproducibility of Myoton and durometer devices to quantify skin stiffness and hardness in sclerotic chronic graft-versus-host disease. Journal Of The American Academy Of Dermatology 2020, 83: ab90. DOI: 10.1016/j.jaad.2020.06.447.Peer-Reviewed Original Research
2019
Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients
Chen F, Wang L, Vain A, Ssempijja Y, Dellalana L, Zhang K, Hood A, Chen H, Jagasia M, Tkaczyk E. Interobserver Reproducibility of the Myoton and Durometer Devices to Measure Skin Stiffness and Hardness in Chronic Cutaneous Graft-Versus-Host Disease Patients. Blood 2019, 134: 4515. DOI: 10.1182/blood-2019-129125.Peer-Reviewed Original ResearchIntraclass correlation coefficientCGVHD patientsInterobserver intraclass correlation coefficientSkin stiffness measurementsCutaneous cGVHDInterobserver reproducibilityChronic cutaneous graftCutaneous Graft-VersusHealth Chronic GraftSkin stiffnessHost disease patientsProgression of sclerosisStiffness measurementLongitudinal studyProspective longitudinal studyMinimal detectable changeTherapeutic response measuresDetectable changeChronic graftGraft-VersusHost diseaseSclerotic cGvHDSkin sclerosisCutaneous graftDisease patientsDiagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease
Chen F, Wang L, Ssempijja Y, Vain A, Jagasia M, Tkaczyk E. Diagnostic Potential of Five Different Biomechanical Parameters to Detect Sclerotic Cutaneous Graft-Versus-Host Disease. Blood 2019, 134: 2002. DOI: 10.1182/blood-2019-129381.Peer-Reviewed Original ResearchCGVHD patientsBMT controlsCross-sectional studyHost diseaseSkin sclerosisSkin scoreBiomechanical parametersSclerotic patientsCutaneous Graft-VersusPost-BMT patientsMechanical stress relaxation timeHigh diagnostic yieldProspective longitudinal studyChronic graftGraft-VersusGVHD patientsSkin involvementUnaffected skinUnivariate analysisHealthy controlsMultivariate predictive modelClinician assessmentDiagnostic yieldTreatment responseResponse assessmentCrowdsourcing to delineate skin affected by chronic graft‐vs‐host disease
Tkaczyk E, Coco J, Wang J, Chen F, Ye C, Jagasia M, Dawant B, Fabbri D. Crowdsourcing to delineate skin affected by chronic graft‐vs‐host disease. Skin Research And Technology 2019, 25: 572-577. PMID: 30786065, PMCID: PMC6719554, DOI: 10.1111/srt.12688.Peer-Reviewed Original ResearchConceptsChronic graftHost diseaseAffected skinPercent body surface areaBody surface areaBoard-certified dermatologistsCurrent clinical standardMedian Dice indexCGVHD patientsPrimary outcomeImportant unmetAffected surface areaThree-dimensional photographsClinical standardsFleiss' kappaDiseaseSkinGraftPractical managementWeak correlationHigh agreementKappaConsensus delineationPatients
2018
Overcoming human disagreement assessing erythematous lesion severity on 3D photos of chronic graft-versus-host disease
Tkaczyk E, Chen F, Wang J, Gandelman J, Saknite I, Dellalana L, Jagasia M, Dawant B. Overcoming human disagreement assessing erythematous lesion severity on 3D photos of chronic graft-versus-host disease. Bone Marrow Transplantation 2018, 53: 1356-1358. PMID: 29740182, PMCID: PMC6858843, DOI: 10.1038/s41409-018-0211-8.Peer-Reviewed Original ResearchSegmentation of skin lesions in chronic graft versus host disease photographs with fully convolutional networks
Wang J, Chen F, Dellalana L, Jagasia M, Tkaczyk E, Dawant B. Segmentation of skin lesions in chronic graft versus host disease photographs with fully convolutional networks. 2018, 10575: 105750n. DOI: 10.1117/12.2293334.Peer-Reviewed Original ResearchBody surface areaHematopoietic stem cell transplantationSkin lesionsChronic graftHost diseaseAllogeneic hematopoietic stem cell transplantationInvolved body surface areaSeverity of cGVHDLife-threatening complicationsStem cell transplantationCGVHD patientsCell transplantationPatient morbidityLesionsPatientsSerial photographyCGVHDGraftDiseaseSkinPreliminary studyEncouraging resultsMorbidityComplicationsTransplantation