Tyler Sharp, PhD
Assistant Professor AdjunctDownloadHi-Res Photo
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Assistant Professor Adjunct of Epidemiology, Epidemiology of Microbial Diseases
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Assistant Professor Adjunct
Assistant Professor Adjunct of Epidemiology, Epidemiology of Microbial Diseases
Biography
Commander Tyler M. Sharp, Ph.D., is an epidemiologist at the Centers for Disease Control and Prevention (CDC) Dengue Branch in San Juan, Puerto Rico. A native of Bowling Green, Ohio, he attended secondary school in the Chicago area and received his Bachelor of Science degree in Molecular Biology and Genetics from the University of Guelph in Ontario, Canada. He received additional training at Montana State University – Bozeman and the Medical Research Council Division of Virology in Glasgow, Scotland. He completed his doctorate in Molecular Virology and Microbiology at Baylor College of Medicine in Houston, Texas, in the laboratory of Dr. Mary K. Estes where he studied the molecular mechanisms of norovirus pathogenesis. During his graduate study, he received additional training at the National Institute for Infectious Diseases in Tokyo, Japan. He joined CDC in 2010 as an Epidemic Intelligence Service officer stationed at CDC Dengue Branch. His current public health and research interests are the epidemiology and pathophysiology of emerging infectious diseases, including dengue, Zika, chikungunya, and leptospirosis. He enjoys international travel, hiking and camping and scuba diving.
Appointments
Epidemiology of Microbial Diseases
Assistant Professor AdjunctPrimary
Other Departments & Organizations
Education & Training
- Epidemic Intelligence Service
- U.S. Centers for Disease Control and Prevention (2012)
- PhD
- Baylor College of Medicine, Molecular Virology and Microbiology (2010)
- BS (Hon)
- University of Guelph, Molecular Biology and Genetics (2004)
Research
Overview
Medical Research Interests
Dengue; Epidemiology; Leptospirosis; Mosquito Control; Puerto Rico
Public Health Interests
Emerging Infectious Diseases; Infectious Diseases
Research at a Glance
Research Interests
Research topics Tyler Sharp is interested in exploring.
Publications
2017
Differences in Prevalence of Symptomatic Zika Virus Infection, by Age and Sex—Puerto Rico, 2016
Lozier MJ, Burke RM, Lopez J, Acevedo V, Amador M, Read JS, Jara A, Waterman SH, Barrera R, Muñoz-Jordan J, Rivera-Garcia B, Sharp TM. Differences in Prevalence of Symptomatic Zika Virus Infection, by Age and Sex—Puerto Rico, 2016. The Journal Of Infectious Diseases 2017, 217: 1678-1689. PMID: 29216376, PMCID: PMC8849542, DOI: 10.1093/infdis/jix630.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsZIKV infectionReverse transcription-polymerase chain reactionEnzyme-linked immunosorbent assaySex-dependent differencesSymptomatic infectionFemale sexSymptomatic Zika virus infectionZika virus infectionSymptomatic ZIKV infectionZika virus diseaseTranscription-polymerase chain reactionNonpregnant womenResidents of householdsZIKV diseaseRecent illnessVirus infectionDisease casesDiagnostic testingStudy participantsInfectionImmunosorbent assayConvenience samplePotential mechanismsChain reactionAgeAcute Zika Virus Infection as a Risk Factor for Guillain-Barré Syndrome in Puerto Rico
Dirlikov E, Medina NA, Major CG, Munoz-Jordan JL, Luciano CA, Rivera-Garcia B, Sharp TM. Acute Zika Virus Infection as a Risk Factor for Guillain-Barré Syndrome in Puerto Rico. JAMA 2017, 318: 1498-1500. PMID: 29049645, PMCID: PMC5817969, DOI: 10.1001/jama.2017.11483.Peer-Reviewed Original ResearchCitationsAltmetric
2016
Use of Household Cluster Investigations to Identify Factors Associated with Chikungunya Virus Infection and Frequency of Case Reporting in Puerto Rico
Bloch D, Roth NM, Caraballo EV, Muñoz-Jordan J, Hunsperger E, Rivera A, Pérez-Padilla J, Garcia B, Sharp TM. Use of Household Cluster Investigations to Identify Factors Associated with Chikungunya Virus Infection and Frequency of Case Reporting in Puerto Rico. PLOS Neglected Tropical Diseases 2016, 10: e0005075. PMID: 27764085, PMCID: PMC5072658, DOI: 10.1371/journal.pntd.0005075.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAcute DiseaseAdolescentAdultAgedAged, 80 and overAir ConditioningAntibodies, ViralChikungunya FeverChikungunya virusChildChild, PreschoolCymbopogonDisease NotificationDisease OutbreaksEnzyme-Linked Immunosorbent AssayExanthemaFamily CharacteristicsFemaleFeverHumansInfantMaleMiddle AgedPoint-of-Care SystemsPolymerase Chain ReactionPuerto RicoYoung AdultConceptsSymptomatic CHIKV infectionRecent CHIKV infectionCHIKV infectionPublic health authoritiesChikungunya virusChikungunya patientsMedical careHealth authoritiesCase reportingAnti-CHIKV IgMAcute febrile illnessChikungunya virus infectionCare rapid diagnostic testsRapid diagnostic testsPuerto Rico DepartmentCluster investigationsAcute illnessFebrile illnessSkin rashResidents of householdsDevelopment of diseaseMultivariable analysisIllness onsetIgG antibodiesIgM ELISAEarly Indicators of Fatal Leptospirosis during the 2010 Epidemic in Puerto Rico
Sharp TM, García B, Pérez-Padilla J, Galloway RL, Guerra M, Ryff KR, Haberling D, Ramakrishnan S, Shadomy S, Blau D, Tomashek KM, Bower WA. Early Indicators of Fatal Leptospirosis during the 2010 Epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2016, 10: e0004482. PMID: 26914210, PMCID: PMC4767218, DOI: 10.1371/journal.pntd.0004482.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsFirst medical visitWhite blood cellsLeptospirosis patientsFatal outcomeMedical visitsFatal leptospirosisLaboratory valuesHospitalized leptospirosis patientsNon-fatal patientsRoutine laboratory valuesLeg painControl patientsMost patientsCase patientsHospital admissionMultivariable analysisIllness onsetPlatelet countDengue patientsFatal casesWBC countLeptospirosis epidemicPatientsMedical careOld male
2013
Virus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico
Sharp TM, Hunsperger E, Santiago GA, Muñoz-Jordan JL, Santiago LM, Rivera A, Rodríguez-Acosta RL, Feliciano L, Margolis HS, Tomashek KM. Virus-Specific Differences in Rates of Disease during the 2010 Dengue Epidemic in Puerto Rico. PLOS Neglected Tropical Diseases 2013, 7: e2159. PMID: 23593526, PMCID: PMC3617145, DOI: 10.1371/journal.pntd.0002159.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute febrile illnessReverse transcriptase-polymerase chain reactionLaboratory-positive casesPrimary infectionDengue casesDENV-1DENV-2Anti-DENV IgM antibodiesSerum specimenMortality of dengueMosquito-transmitted dengue virusPrimary DENV infectionPassive dengue surveillance systemHealth care providersPrimary prevention interventionsTranscriptase-polymerase chain reactionOnly age groupDENV nucleic acidLaboratory diagnostic dataRates of diseaseFebrile illnessSevere dengueDENV infectionIgM antibodiesDENV antigen
Academic Achievements & Community Involvement
honor Juan Carlos Finlay Award
National AwardUnited States Public Health Service, Hispanic Officers Advocacy GroupDetails10/01/2019United Stateshonor Bailey K. Ashford Medal
National AwardThe American Society for Tropical Medicine and HygieneDetails10/28/2018United States
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