Featured Publications
A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases
Liu W, Deng W, Chen M, Dong Z, Zhu B, Yu Z, Tang D, Sauler M, Lin C, Wain L, Cho M, Kaminski N, Zhao H. A statistical framework to identify cell types whose genetically regulated proportions are associated with complex diseases. PLOS Genetics 2023, 19: e1010825. PMID: 37523391, PMCID: PMC10414598, DOI: 10.1371/journal.pgen.1010825.Peer-Reviewed Original ResearchConceptsCell typesDisease-associated tissuesWide association studyComplex diseasesCell type proportionsDisease-relevant tissuesReal GWAS dataFunctional genesTranscriptomic dataGWAS dataGenetic dataAssociation studiesNovel statistical frameworkChronic obstructive pulmonary diseaseStatistical frameworkObstructive pulmonary diseaseIdiopathic pulmonary fibrosisBreast cancer riskType proportionsBlood CD8Pulmonary diseasePulmonary fibrosisPredictive biomarkersLung tissueBreast cancer
2023
Predicting Breast Cancer Risk for Women Veterans of African Ancestry in the Million Veteran Program
Luoh S, Minnier J, Zhao H, Gao L. Predicting Breast Cancer Risk for Women Veterans of African Ancestry in the Million Veteran Program. Health Equity 2023, 7: 303-306. PMID: 37284538, PMCID: PMC10240329, DOI: 10.1089/heq.2023.0011.Peer-Reviewed Original ResearchBreast cancer riskBreast cancerMillion Veteran ProgramCancer riskPolygenic risk scoresWomen veteransHigher breast cancer riskRisk prediction instrumentsIncident breast cancerLow-risk womenBreast cancer preventionBreast cancer incidenceIndividual breast cancer riskBreast cancer mortalityPredicting Breast Cancer RiskBreast cancer screeningVeteran ProgramMajor health threatPrediction instrumentGenetic variantsEuropean ancestry womenProspective cohortRisk womenCancer mortalityCancer screening