2022
Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene
George S, Suwondo P, Akorli J, Otchere J, Harrison LM, Bilguvar K, Knight JR, Humphries D, Wilson MD, Caccone A, Cappello M. Application of multiplex amplicon deep-sequencing (MAD-seq) to screen for putative drug resistance markers in the Necator americanus isotype-1 β-tubulin gene. Scientific Reports 2022, 12: 11459. PMID: 35794459, PMCID: PMC9259660, DOI: 10.1038/s41598-022-15718-1.Peer-Reviewed Original ResearchConceptsSingle nucleotide polymorphismsPeriodic mass drug administrationHigh-risk groupCross-sectional studyDrug resistance markersMass drug administrationResistance-associated mutationsHookworm Necator americanusPost-treatment samplesIsotype-1 β-tubulin geneHookworm infectionPersistent infectionResistance markersDrug AdministrationNecator americanusInfection statusVeterinary nematodesInfectionMarkersNucleotide polymorphismsSensitive toolBenzimidazole drugsNucleotide alleles
2020
Core Principles in Nutrition: Nutrient Needs, Metabolism, and Potential Influences on Infectious Diseases
Barffour M, Humphries D. Core Principles in Nutrition: Nutrient Needs, Metabolism, and Potential Influences on Infectious Diseases. Nutrition And Health 2020, 23-82. DOI: 10.1007/978-3-030-56913-6_2.Peer-Reviewed Original ResearchDisease outcomeInfectious diseasesImpact of undernutritionInfectious disease outcomesProtein-calorie deficitsWorld Health Organization monographElevated riskMicronutrient interventionsImmune systemNutritional statusSpecific macronutrientsInfectionMalnutritionDiseaseOutcomesMetabolismCurrent understandingPotential pathwaysUndernutritionMortalityPotential influencePublic Health and Clinical Implications of Nutrition-Infection Interactions
Vermund S, Scott M, Humphries D. Public Health and Clinical Implications of Nutrition-Infection Interactions. Nutrition And Health 2020, 459-481. DOI: 10.1007/978-3-030-56913-6_16.Peer-Reviewed Original ResearchInfectious agentsNutritional statusClinical implicationsRole of obesityDefinitive risk factorsSeverity of malariaSuboptimal nutritional statusMajor infectious agentsHealth of personsClinical courseClinical managementRisk factorsClinical nutritionHigh mortalityInfectious diseasesCOVID-19ObesityPublic healthInfectionDiseaseSeverityNutritionHealthBacterial diseasesStatusPathways Linking Nutritional Status and Infectious Disease: Causal and Conceptual Frameworks
Humphries D, Scott M, Vermund S. Pathways Linking Nutritional Status and Infectious Disease: Causal and Conceptual Frameworks. Nutrition And Health 2020, 3-22. DOI: 10.1007/978-3-030-56913-6_1.Peer-Reviewed Original ResearchHost nutritional statusNutritional statusInfectious diseasesExperience of infectionImpact of nutritionInfluence of nutritionImmunological responseDrug interventionEpidemiological studiesHost responseDisease severityInfectionMechanisms of causalityDiseaseMicrobial pathogenesisFuture studiesStatusUnderstanding of causationNutritionPathogensSame populationPathogenesisMalnutritionSeverityResponse
2013
Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment
Humphries D, Simms BT, Davey D, Otchere J, Quagraine J, Terryah S, Newton S, Berg E, Harrison LM, Boakye D, Wilson M, Cappello M. Hookworm Infection among School Age Children in Kintampo North Municipality, Ghana: Nutritional Risk Factors and Response to Albendazole Treatment. American Journal Of Tropical Medicine And Hygiene 2013, 89: 540-548. PMID: 23836564, PMCID: PMC3771297, DOI: 10.4269/ajtmh.12-0605.Peer-Reviewed Original ResearchConceptsKintampo North MunicipalityHookworm infectionCure rateSchool-aged childrenModest cure ratesSingle-dose albendazoleNutritional risk factorsLevels of antibodiesYears of ageAge childrenMalaria parasitemiaAlbendazole treatmentRisk factorsChildren 6InfectionInfection statusHealth careSignificant predictorsAnimal foodsHookwormAlbendazoleFurther investigationAgeChildrenLow consumption
2012
The promise and pitfalls of mass drug administration to control intestinal helminth infections
Humphries D, Nguyen S, Boakye D, Wilson M, Cappello M. The promise and pitfalls of mass drug administration to control intestinal helminth infections. Current Opinion In Infectious Diseases 2012, 25: 584-589. PMID: 22903231, DOI: 10.1097/qco.0b013e328357e4cf.Peer-Reviewed Original ResearchConceptsMass drug administrationIntestinal helminth infectionsHelminth infectionsDrug AdministrationSoil-transmitted nematode infectionsIntensity of schistosomiasisHigh-risk groupResource-limited settingsLong-term controlSignificant morbidityPregnant womenLong-term benefitsNew drug developmentIntensity of infectionIntestinal helminthsEndemic areasConsistent benefitInfectionChemotherapeutic interventionCertain populationsDrug developmentBenzimidazole anthelminthicsIntensive monitoringPrevalenceAdministrationNutritional risk factors for hookworm infection among school age children in the Kintampo North Municipality, Ghana
Humphries D, Simms B, Davey D, Otchere J, Quagraine J, Berg E, Newton S, Harrison L, Boakye D, Wilson M, Cappello M. Nutritional risk factors for hookworm infection among school age children in the Kintampo North Municipality, Ghana. The FASEB Journal 2012, 26: 1028.6-1028.6. DOI: 10.1096/fasebj.26.1_supplement.1028.6.Peer-Reviewed Original ResearchHookworm infectionKintampo North MunicipalityRisk factorsInfection statusSchool-aged childrenNutritional risk factorsDietary risk factorsMalaria infection statusSignificant risk factorsDietary diversityDegree of stuntingLow-intensity infectionsChildren ages 6Recent dewormingClinical sequelaeResults PrevalenceHigh prevalenceFood groupsIntensity infectionsNutritional statusCross-sectional sampleHookwormInfectionAnemiaHAZ scores
2011
Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure
Humphries D, Mosites E, Otchere J, Twum WA, Woo L, Jones-Sanpei H, Harrison LM, Bungiro RD, Benham-Pyle B, Bimi L, Edoh D, Bosompem K, Wilson M, Cappello M. Epidemiology of Hookworm Infection in Kintampo North Municipality, Ghana: Patterns of Malaria Coinfection, Anemia, and Albendazole Treatment Failure. American Journal Of Tropical Medicine And Hygiene 2011, 84: 792-800. PMID: 21540391, PMCID: PMC3083749, DOI: 10.4269/ajtmh.2011.11-0003.Peer-Reviewed Original ResearchConceptsPoor nutritional statusHookworm infectionRisk factorsNutritional statusOverall egg reduction rateSerum immunoglobulin G (IgG) reactivitiesCross-sectional pilot studyEgg reduction rateImmunoglobulin G reactivityKintampo North MunicipalityAlbendazole therapyKintampo NorthMalaria coinfectionTreatment failureOverall prevalenceHigh prevalenceRepeat examinationEgg excretionSecretory antigensInfectionPilot studyCoinfectionSignificant reductionTherapyHigh rate
2002
Emerging Patterns of Hookworm Infection: Influence of Aging on the Intensity of Necator Infection in Hainan Province, People's Republic of China
Bethony J, Chen J, Lin S, Xiao S, Zhan B, Li S, Xue H, Xing F, Humphries D, Yan W, Chen G, Foster V, Hawdon JM, Hotez PJ. Emerging Patterns of Hookworm Infection: Influence of Aging on the Intensity of Necator Infection in Hainan Province, People's Republic of China. Clinical Infectious Diseases 2002, 35: 1336-1344. PMID: 12439796, DOI: 10.1086/344268.Peer-Reviewed Original Research