2023
Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV
Cohen S, DePhilippis D, Deng Y, Dziura J, Ferguson T, Fucito L, Justice A, Maisto S, Marconi V, Molina P, Paris M, Rodriguez‐Barradas M, Simberkoff M, Petry N, Fiellin D, Edelman E. Perspectives on contingency management for alcohol use and alcohol‐associated conditions among people in care with HIV. Alcohol Clinical And Experimental Research 2023, 47: 1783-1797. PMID: 37524371, PMCID: PMC10828101, DOI: 10.1111/acer.15159.Peer-Reviewed Original ResearchUnhealthy alcohol useAlcohol useContingency managementPrimary care settingSubset of participantsReward structureEvidence-based approachHIV clinicImplementation science frameworkTreatment trialsClinical trialsIntervention feasibilityCare settingsPromoting ActionAlcohol consumptionRelated conditionsBiochemical testingClinical contextHIVReward schedulePatientsReward processesInterventionTrialsBehavior changeFactors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use
Bahji A, Gordon K, Crystal S, Satre D, Wiliams E, Edelman E, Justice A. Factors Associated with Bothersome Symptoms in Individuals With and Without HIV Who Report Alcohol Use. AIDS And Behavior 2023, 27: 2455-2462. PMID: 36622487, PMCID: PMC10225332, DOI: 10.1007/s10461-022-03972-3.Peer-Reviewed Original Research
2022
Statins Utilization in Adults With HIV: The Treatment Gap and Predictors of Statin Initiation
Coburn SB, Lang R, Zhang J, Palella FJ, Horberg MA, Castillo-Mancilla J, Gebo K, Galaviz KI, Gill MJ, Silverberg MJ, Hulgan T, Elion RA, Justice AC, Moore RD, Althoff KN, Research and Design of IeDEA F. Statins Utilization in Adults With HIV: The Treatment Gap and Predictors of Statin Initiation. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 469-478. PMID: 36053091, PMCID: PMC9649872, DOI: 10.1097/qai.0000000000003083.Peer-Reviewed Original ResearchConceptsACC/AHA guidelinesStatin initiationStatin eligibilityAHA guidelinesTreatment gapNorth American AIDS Cohort CollaborationATP III guidelinesCohort CollaborationPrevalence ratiosUS cohortStatin utilizationEligibility criteriaStatinsPoisson regressionConfidence intervalsAnnual proportionHIVPWHEligibilityAppropriate candidatesCalendar yearPredictorsGuidelinesInitiationCohortEpigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV
Titanji BK, Lee M, Wang Z, Chen J, Hui Q, Re V, So-Armah K, Justice AC, Xu K, Freiberg M, Gwinn M, Marconi VC, Sun YV. Epigenome-wide association study of biomarkers of liver function identifies albumin-associated DNA methylation sites among male veterans with HIV. Frontiers In Genetics 2022, 13: 1020871. PMID: 36303554, PMCID: PMC9592923, DOI: 10.3389/fgene.2022.1020871.Peer-Reviewed Original ResearchLiver diseaseLiver biomarkersLiver functionDNAm age accelerationAge accelerationVeterans Aging Cohort StudyEpigenome-wide association studiesFIB-4 scoreAging Cohort StudyMale PWHAPRI scoreCohort studyPlatelet countTotal bilirubinAlanine transaminaseClinical dataBlood samplesIndependent cohortSerum albuminMale veteransHIVImportant causeSignificant associationPWHDNAm sitesPredictive Risk Model for Serious Falls Among Older Persons Living With HIV
Womack JA, Murphy TE, Leo-Summers L, Bates J, Jarad S, Smith AC, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt CA, Justice AC. Predictive Risk Model for Serious Falls Among Older Persons Living With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 91: 168-174. PMID: 36094483, PMCID: PMC9470988, DOI: 10.1097/qai.0000000000003030.Peer-Reviewed Original ResearchConceptsMiddle-aged veteransOlder PWHAntiretroviral therapySerious fallsOlder personsVeterans Aging Cohort StudyMeasures of multimorbidityAging Cohort StudyBody mass indexMultivariable logistic regressionPredictive risk modelCohort studyMass indexInjury codesElevated riskGeneral populationSix monthsPWHLogistic regressionPotential predictorsSubstance useRadiology reportsHIVExternal causesVeteransSARS-CoV-2 Testing and Positivity Among Persons With and Without HIV in 6 US Cohorts
Park LS, McGinnis KA, Gordon KS, Justice AC, Leyden W, Silverberg MJ, Skarbinski J, Jefferson C, Horberg M, Certa J, Napravnik S, Edwards JK, Westreich D, Bastarache L, Gangireddy S, Benning L, D'Souza G, Williams C, Althoff KN. SARS-CoV-2 Testing and Positivity Among Persons With and Without HIV in 6 US Cohorts. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2022, 90: 249-255. PMID: 35195574, PMCID: PMC9203911, DOI: 10.1097/qai.0000000000002943.Peer-Reviewed Original ResearchConceptsSARS-CoV-2SARS-CoV-2 testingHIV statusClinical cohortPositive SARS-CoV-2 testSARS-CoV-2 positivitySARS-CoV-2 testCOVID-19-related outcomesProportion of PWHProportion of patientsSARS-CoV-2 variantsCOVID-19 vaccineLatest therapeutic optionsTherapeutic optionsUS cohortPositivity proportionInterval cohortPWHPWOHCohortHealth systemDiverse cohortHIVPositivityTesting proportionsChronic pain and substance use disorders among older sexual minority men living with HIV: Implications for HIV disease management across the HIV care continuum
Taylor SW, McKetchnie SM, Batchelder AW, Justice A, Safren SA, O’Cleirigh C. Chronic pain and substance use disorders among older sexual minority men living with HIV: Implications for HIV disease management across the HIV care continuum. AIDS Care 2022, 35: 614-623. PMID: 35653300, PMCID: PMC9715850, DOI: 10.1080/09540121.2022.2076801.Peer-Reviewed Original ResearchConceptsOlder sexual minority menChronic painOpioid use disorderHigher pain ratingsAlcohol use disorderSexual minority menUse disordersPain ratingsMissed appointmentsHIV disease managementHIV care continuumHIV care appointmentsCross-sectional studyMinority menHIV carePain managementMedication adherenceHigher painCare continuumCritical health issuePainHIVSubstance use behaviorsHealth issuesSubstance usePatient-Reported Bothersome Symptoms Attributed to Alcohol Use Among People With and Without HIV
Gordon KS, Becker WC, Bryant KJ, Crystal S, Maisto SA, Marshall BDL, McInnes DK, Satre DD, Williams EC, Edelman EJ, Justice AC. Patient-Reported Bothersome Symptoms Attributed to Alcohol Use Among People With and Without HIV. AIDS And Behavior 2022, 26: 3589-3596. PMID: 35553287, PMCID: PMC10084471, DOI: 10.1007/s10461-022-03628-2.Peer-Reviewed Original ResearchDelayed presentation of HIV among older individuals: a growing problem
Justice AC, Goetz MB, Stewart CN, Hogan BC, Humes E, Luz PM, Castilho JL, Nash D, Brazier E, Musick B, Yiannoutsos C, Malateste K, Jaquet A, Cornell M, Shamu T, Rajasuriar R, Jiamsakul A, Althoff KN. Delayed presentation of HIV among older individuals: a growing problem. The Lancet HIV 2022, 9: e269-e280. PMID: 35218732, PMCID: PMC9128643, DOI: 10.1016/s2352-3018(22)00003-0.Peer-Reviewed Original ResearchConceptsLate presentationOlder individualsInternational epidemiology DatabasesAssociation of agePresentation of HIVElectronic medical recordsProportion of peopleEpidemiology DatabaseHIV infectionAIDS (IeDEA) consortiumMedical recordsEffective treatmentAge groupsOlder agePresentationAgeIndividualsHIVInfectionCarePreventionPredicting counterfactual risks under hypothetical treatment strategies: an application to HIV
Dickerman BA, Dahabreh IJ, Cantos KV, Logan RW, Lodi S, Rentsch CT, Justice AC, Hernán MA. Predicting counterfactual risks under hypothetical treatment strategies: an application to HIV. European Journal Of Epidemiology 2022, 37: 367-376. PMID: 35190946, PMCID: PMC9189026, DOI: 10.1007/s10654-022-00855-8.Peer-Reviewed Original ResearchA Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020)
Smith A, Breazeale S, Goulet JL, Vlahov D, Justice AC, Womack JA. A Systematic Review of Risk Factors for Suicide Among Persons Living with HIV (1996–2020). AIDS And Behavior 2022, 26: 2559-2573. PMID: 35107660, DOI: 10.1007/s10461-022-03591-y.Peer-Reviewed Original ResearchConceptsRisk factorsHIV-specific risk factorsInjection drug useHIV-1 RNACause of morbidityShare risk factorsPrevious suicide attemptsQuantitative study designHIV diagnosisPeer-reviewed journalsHIV infectionEligible studiesInclusion criteriaPsychiatric illnessElevated riskGeneral populationAlcohol misuseElectronic databasesDrug useSystematic reviewSuicide attemptsStudy designInitial searchSearch termsHIVPeriods of Homelessness Linked to Higher VACS Index Among HIV-Positive People Who Use Drugs
Reddon H, Socias ME, Justice A, Cui Z, Nosova E, Barrios R, Fairbairn N, Marshall BDL, Milloy M. Periods of Homelessness Linked to Higher VACS Index Among HIV-Positive People Who Use Drugs. AIDS And Behavior 2022, 26: 1739-1749. PMID: 35064852, PMCID: PMC9150923, DOI: 10.1007/s10461-021-03524-1.Peer-Reviewed Original ResearchConceptsHIV disease progressionART adherenceDisease progressionAntiretroviral therapyVeterans Aging Cohort Study (VACS) IndexVACS Index scoreSignificant risk factorsHIV-positive peopleVACS IndexCause mortalityProspective cohortRisk factorsMortality riskIndex scoreStudy indicesAdherenceProgressionLongitudinal relationshipHIVImpact of homelessnessPWUDUnregulated drugsAssociationDrugsFuture studies
2021
The shifting age distribution of people with HIV using antiretroviral therapy in the United States
Althoff KN, Stewart CN, Humes E, Zhang J, Gerace L, Boyd CM, Wong C, Justice AC, Gebo KA, Thorne JE, Rubtsova AA, Horberg MA, Silverberg MJ, Leng SX, Rebeiro PF, Moore RD, Buchacz K, Kasaie P. The shifting age distribution of people with HIV using antiretroviral therapy in the United States. AIDS 2021, 36: 459-471. PMID: 34750289, PMCID: PMC8795488, DOI: 10.1097/qad.0000000000003128.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyRace/ethnicityNorth American AIDS Cohort CollaborationHIV acquisition riskHIV Epidemic goalsOverall median ageSubgroups of sexRelative reductionAge distributionCohort CollaborationHIV diagnosisMedian ageRisk groupsUS CentersAcquisition riskHIVUS populationDisease controlSurveillance reportsDiscrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America
McGinnis KA, Justice AC, Moore RD, Silverberg MJ, Althoff KN, Karris M, Lima VD, Crane HM, Horberg MA, Klein MB, Gange SJ, Gebo KA, Mayor A, Tate JP, Benson C, Bosch R, Kirk G, Marconi V, Colasanti J, Mayer K, Grasso C, Hogg R, Lima V, Montaner J, Sereda P, Salters K, Buchacz K, Li J, Gebo K, Moore R, Moore R, Jacobson J, Horberg M, Silverberg M, Thorne J, Brown T, Tien P, D’Souza G, Smith G, Loutfy M, Gupta M, Klein M, Rabkin C, Kroch A, Burchell A, Betts A, Lindsay J, Nijhawan A, Mayor A, Gill M, Martin J, Li J, Brooks J, Saag M, Mugavero M, Willig J, Bamford L, Karris M, Eron J, Napravnik S, Kitahata M, Crane H, Sterling T, Haas D, Rebeiro P, Turner M, McGinnis K, Justice A, Moore R, Althoff K, Gange S, Kitahata M, Lee J, Saag M, Horberg M, Klein M, McKaig R, Freeman A, Moore R, Althoff K, Freeman A, Kitahata M, Van Rompaey S, Crane H, Morton L, McReynolds J, Lober W, Gange S, Lee J, Hogan B, You B, Humes E, Gerace L, Stewart C, Coburn S. Discrimination and Calibration of the Veterans Aging Cohort Study Index 2.0 for Predicting Mortality Among People With Human Immunodeficiency Virus in North America. Clinical Infectious Diseases 2021, 75: 297-304. PMID: 34609485, PMCID: PMC9410720, DOI: 10.1093/cid/ciab883.Peer-Reviewed Original ResearchConceptsNorth American AIDS Cohort CollaborationVACS Index 2.0National Death IndexHIV-1 RNAHuman immunodeficiency virusCopies/mLRisk of mortalityRace/ethnicityCohort CollaborationNA-ACCORDCause mortalityCD4 countMedian ageDeath IndexImmunodeficiency virusPredicting MortalityMortality ascertainmentMortality rateMortalitySpecific biomarkersPWHDiverse cohortObserved mortalityCohortHIVBrief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV?
Womack JA, Murphy TE, Ramsey C, Bathulapalli H, Leo-Summers L, Smith AC, Bates J, Jarad S, Gill TM, Hsieh E, Rodriguez-Barradas MC, Tien PC, Yin MT, Brandt C, Justice AC. Brief Report: Are Serious Falls Associated With Subsequent Fragility Fractures Among Veterans Living With HIV? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 88: 192-196. PMID: 34506360, PMCID: PMC8513792, DOI: 10.1097/qai.0000000000002752.Peer-Reviewed Original ResearchConceptsSubsequent fragility fracturesFragility fracturesAntiretroviral therapySerious fallsRisk factorsVeterans Aging Cohort StudyAging Cohort StudyMultivariable logistic regressionUpper arm fracturesMiddle-aged populationYears of ageAlcohol use disorderCohort studyHip fractureVertebral fracturesArm fracturesInjury codesICD9 codesGeneral populationUse disordersLogistic regressionIntegrase inhibitorsOlder adultsRadiology reportsHIVChange in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV
McGinnis KA, Tate JP, Bryant KJ, Justice AC, O’Connor P, Rodriguez-Barradas MC, Crystal S, Cutter CJ, Hansen NB, Maisto SA, Marconi VC, Williams EC, Cook RL, Gordon AJ, Gordon KS, Eyawo O, Edelman EJ, Fiellin DA. Change in Alcohol Use Based on Self-Report and a Quantitative Biomarker, Phosphatidylethanol, in People With HIV. AIDS And Behavior 2021, 26: 786-794. PMID: 34542779, DOI: 10.1007/s10461-021-03438-y.Peer-Reviewed Original ResearchTwelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIV
Wyse JJ, McGinnis KA, Edelman EJ, Gordon AJ, Manhapra A, Fiellin DA, Moore BA, Korthuis PT, Kennedy AJ, Oldfield BJ, Gaither JR, Gordon KS, Skanderson M, Barry DT, Bryant K, Crystal S, Justice AC, Kraemer KL. Twelve-Month Retention in Opioid Agonist Treatment for Opioid Use Disorder Among Patients With and Without HIV. AIDS And Behavior 2021, 26: 975-985. PMID: 34495424, PMCID: PMC8840957, DOI: 10.1007/s10461-021-03452-0.Peer-Reviewed Original ResearchConceptsOpioid agonist therapyOpioid use disorderVeterans Aging Cohort StudyHIV statusUse disordersOpioid agonist treatmentAging Cohort StudyDiagnosis of HCVTwelve-month retentionPositive health outcomesOAT retentionAgonist therapyCohort studyHIV managementAgonist treatmentPredictors of retentionPatientsHealth outcomesHistory of homelessnessHIVLower likelihoodImproved likelihoodLikelihood of initiationBuprenorphineDisordersCD4+ cell count and outcomes among HIV-infected compared with uninfected medical ICU survivors in a national cohort
Akgün KM, Krishnan S, Butt AA, Gibert CL, Graber CJ, Huang L, Pisani MA, Rodriguez-Barradas MC, Hoo GWS, Justice AC, Crothers K, Tate JP. CD4+ cell count and outcomes among HIV-infected compared with uninfected medical ICU survivors in a national cohort. AIDS 2021, 35: 2355-2365. PMID: 34261095, PMCID: PMC8563390, DOI: 10.1097/qad.0000000000003019.Peer-Reviewed Original ResearchMortality Among Persons Entering HIV Care Compared With the General U.S. Population : An Observational Study.
Edwards JK, Cole SR, Breger TL, Rudolph JE, Filiatreau LM, Buchacz K, Humes E, Rebeiro PF, D'Souza G, Gill MJ, Silverberg MJ, Mathews WC, Horberg MA, Thorne J, Hall HI, Justice A, Marconi VC, Lima VD, Bosch RJ, Sterling TR, Althoff KN, Moore RD, Saag M, Eron JJ. Mortality Among Persons Entering HIV Care Compared With the General U.S. Population : An Observational Study. Annals Of Internal Medicine 2021, 174: 1197-1206. PMID: 34224262, PMCID: PMC8453103, DOI: 10.7326/m21-0065.Peer-Reviewed Original ResearchConceptsGeneral U.S. populationHIV careU.S. populationNorth American AIDS Cohort CollaborationHIV clinical careObservational cohort studyTreatment of adultsRace/ethnicityCohort CollaborationCause mortalityCohort studyHIV infectionModifiable factorsComparable personsObservational studyClinical careHigh riskGeneral populationSociodemographic factorsHealth StatisticsMortalityHIVKaplan-Meier estimatorCareFive yearsNIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research.
Pahwa S, Deeks S, Zou S, Tomitch N, Miller-Novak L, Caler E, Justice A, Sacktor N, Gabuzda D, Hunt PW, Brown T, Kurth A, Baral S, Mugavero M, Mayer KH, Mendenhall E, Detels R, Mutabazi V. NIH Workshop on HIV-Associated Comorbidities, Coinfections, and Complications: Summary and Recommendation for Future Research. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 86: 11-18. PMID: 33306561, PMCID: PMC7982002, DOI: 10.1097/qai.0000000000002528.Peer-Reviewed Original ResearchConceptsPotent antiretroviral therapyImplementation science researchBasic science researchAIDS comorbiditiesAntiretroviral therapyMiddle-income countriesClinical researchHealthy agingSyndemics researchHealth spanNIH workshopComorbiditiesComplicationsHIVPWHNormal lifespanCoinfectionIncome countriesNIHPressing gapsPotential prioritiesInvestigatorsPopulation researchRegimensWG members