2024
Bayesian mixed model inference for genetic association under related samples with brain network phenotype
Tian X, Wang Y, Wang S, Zhao Y, Zhao Y. Bayesian mixed model inference for genetic association under related samples with brain network phenotype. Biostatistics 2024, 25: 1195-1209. PMID: 38494649, DOI: 10.1093/biostatistics/kxae008.Peer-Reviewed Original ResearchSample relatednessGenetic studiesGenetic association studiesRisk genetic variantsImaging genetics studiesPopulation structureAssociation studiesQuantitative phenotypesQuantitative geneticsGenetic basisGenetic variantsGenetic associationGenetic contributionPhenotypeRelatednessConnectivity traitsNetwork phenotypesConnectivity phenotypesMarkov chain Monte CarloMixed-effects modelsPedigreeGeneticsBiological structuresTraitsHuman Connectome Project
2021
Identifying highly heritable brain amyloid phenotypes through mining Alzheimer’s imaging and sequencing biobank data
Bao J, Wen Z, Kim M, Zhao X, Lee B, Jung S, Davatzikos C, Saykin A, Thompson P, Kim D, Zhao Y, Shen L. Identifying highly heritable brain amyloid phenotypes through mining Alzheimer’s imaging and sequencing biobank data. 2021, 109-120. DOI: 10.1142/9789811250477_0011.Peer-Reviewed Original ResearchPolygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes.
Yingxuan E, Yao X, Liu K, Risacher SL, Saykin AJ, Long Q, Zhao Y, Shen L. Polygenic mediation analysis of Alzheimer's disease implicated intermediate amyloid imaging phenotypes. AMIA Annual Symposium Proceedings 2021, 2020: 422-431. PMID: 33936415, PMCID: PMC8075527.Peer-Reviewed Original Research
2020
Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes
Zhao Y, Li T, Zhu H. Bayesian sparse heritability analysis with high-dimensional neuroimaging phenotypes. Biostatistics 2020, 23: 467-484. PMID: 32948880, PMCID: PMC9308456, DOI: 10.1093/biostatistics/kxaa035.Peer-Reviewed Original ResearchConceptsHeritability analysisHuman complex traitsLarge-scale phenotypeQuantitative geneticsComplex traitsPhenotypic variationTrait selectionGenetic datasetsSingle phenotypeDownstream analysisGenetic contributionHeritability estimationPhenotypeTraitsCentral roleNeuroimaging phenotypesUnited Kingdom BiobankHierarchical selectionPhenotypic methodsGeneticsHeritabilitySelectionVariationBrain variation