2016
Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey
Mesa R, Miller CB, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Paranagama DC, Dubinski DG, Boyle J, Mascarenhas JO. Myeloproliferative neoplasms (MPNs) have a significant impact on patients’ overall health and productivity: the MPN Landmark survey. BMC Cancer 2016, 16: 167. PMID: 26922064, PMCID: PMC4769833, DOI: 10.1186/s12885-016-2208-2.Peer-Reviewed Original ResearchConceptsPrognostic risk scoreMyeloproliferative neoplasmsRisk scorePolycythemia veraEssential thrombocythemiaDisease burdenDaily livingOverall healthSymptom severityMedian disease durationLandmark surveyPatient's overall healthOverall disease burdenRisk of mortalityMedian respondent ageLower symptom severityDisease durationSymptom burdenPatients' qualityMPN subtypesTreatment managementPatientsConclusionsThese findingsResultsThe surveyQoL
2014
Impact of Myeloproliferative Neoplasms (MPNs) on Patients’ Overall Health and Productivity: Results from the MPN LANDMARK SURVEY in the United States
Mesa R, Miller C, Thyne M, Mangan J, Goldberger S, Fazal S, Ma X, Wilson W, Dubinski D, Boyle J, Mascarenhas J. Impact of Myeloproliferative Neoplasms (MPNs) on Patients’ Overall Health and Productivity: Results from the MPN LANDMARK SURVEY in the United States. Blood 2014, 124: 3183. DOI: 10.1182/blood.v124.21.3183.3183.Peer-Reviewed Original ResearchPrognostic risk scoreMajority of patientsIncyte CorporationLow-risk scoresRisk scoreMyeloproliferative neoplasmsEssential thrombocythemiaOverall healthSymptom burdenDays of workSpeakers bureauPolycythemia veraSignificant burdenSubset of patientsTotal symptom scoreImpact of symptomsAdvisory CommitteeHigh-risk scoreChronic myeloproliferative neoplasmsNovartis Pharmaceuticals CorporationQuality of lifeLandmark surveyMarked burdenEligible patientsSymptom scores