2021
VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis
Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis. CHEST Journal 2021, 161: 418-428. PMID: 34419428, DOI: 10.1016/j.chest.2021.08.050.Peer-Reviewed Original ResearchConceptsIncidence of DVTRandomized clinical trialsMechanical compressive deviceRisk of DVTIll adultsCombination therapyRCTs of patientsSystematic reviewAdults A Systematic ReviewCombination pharmacologic therapyCompressive devicePrimary pharmacologic agentsRisk of VTELow-certainty evidencePrevention of VTEA Systematic ReviewNetwork Meta-AnalysisFull-text reviewThromboprophylaxis agentsVenous thromboprophylaxisVTE prophylaxisRecommendations AssessmentPharmacologic therapyPulmonary embolismIll patients
2019
A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss
Ahmadzai N, Kilty S, Cheng W, Esmaeilisaraji L, Wolfe D, Bonaparte JP, Schramm D, Fitzpatrick E, Lin V, Skidmore B, Moher D, Hutton B. A systematic review and network meta-analysis of existing pharmacologic therapies in patients with idiopathic sudden sensorineural hearing loss. PLOS ONE 2019, 14: e0221713. PMID: 31498809, PMCID: PMC6733451, DOI: 10.1371/journal.pone.0221713.Peer-Reviewed Original ResearchConceptsIdiopathic sudden sensorineural hearing lossSudden sensorineural hearing lossSensorineural hearing lossPTA improvementSystemic steroidsHearing recoveryHearing lossHigh riskManagement of ISSNHLSystematic reviewPure-tone average improvementSystemic steroid treatmentCause of disabilityExperienced information specialistSelection of treatmentQuality of lifeMajority of casesRemoval of duplicatesIntratympanic steroidsIntravenous steroidsIT steroidsOral steroidsPharmacologic therapySteroid treatmentActive treatment