2022
What is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Meulenkamp B, Woolnough T, Cheng W, Stacey D, Richards M, Gupta A, Fergusson D, Graham I. What is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Foot & Ankle Orthopaedics 2022, 7: 2473011421s00804. PMCID: PMC9673542, DOI: 10.1177/2473011421s00804.Peer-Reviewed Original ResearchAcute Achilles tendon ruptureAchilles tendon ruptureTendon ruptureRisk of reruptureOpen surgeryLower riskFunctional rehabilitationRandom-effects Bayesian networkPatient-reported outcome scoresPatient-reported outcome measuresPrimary immobilizationSmall sample sizeOpen surgical repairRisk of complicationsRandomized Controlled TrialsMultiple treatment optionsNetwork Meta-AnalysisSpecific patient populationsStudy treatment armsConsiderable clinical heterogeneityGrey literature sourcesTraditional study designsChronic rupturesMIS repairDeep infection
2021
VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis
Fernando SM, Tran A, Cheng W, Sadeghirad B, Arabi YM, Cook DJ, Møller MH, Mehta S, Fowler RA, Burns KEA, Wells PS, Carrier M, Crowther MA, Scales DC, English SW, Kyeremanteng K, Kanji S, Kho ME, Rochwerg B. VTE Prophylaxis in Critically Ill Adults A Systematic Review and Network Meta-analysis. CHEST Journal 2021, 161: 418-428. PMID: 34419428, DOI: 10.1016/j.chest.2021.08.050.Peer-Reviewed Original ResearchConceptsIncidence of DVTRandomized clinical trialsMechanical compressive deviceRisk of DVTIll adultsCombination therapyRCTs of patientsSystematic reviewAdults A Systematic ReviewCombination pharmacologic therapyCompressive devicePrimary pharmacologic agentsRisk of VTELow-certainty evidencePrevention of VTEA Systematic ReviewNetwork Meta-AnalysisFull-text reviewThromboprophylaxis agentsVenous thromboprophylaxisVTE prophylaxisRecommendations AssessmentPharmacologic therapyPulmonary embolismIll patientsWhat Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials
Meulenkamp B, Woolnough T, Cheng W, Shorr R, Stacey D, Richards M, Gupta A, Fergusson D, Graham ID. What Is the Best Evidence to Guide Management of Acute Achilles Tendon Ruptures? A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials. Clinical Orthopaedics And Related Research® 2021, 479: 2119-2131. PMID: 34180874, PMCID: PMC8445578, DOI: 10.1097/corr.0000000000001861.Peer-Reviewed Original ResearchConceptsAcute Achilles tendon ruptureAchilles tendon ruptureTendon ruptureRisk of reruptureOpen surgeryLower riskFunctional rehabilitationSystematic reviewRandom-effects Bayesian networkPatient-reported outcome scoresPatient-reported outcome measuresPrimary immobilizationSmall sample sizeGrades of RecommendationOpen surgical repairRisk of complicationsMultiple treatment optionsNetwork Meta-AnalysisRandomized Controlled TrialsMeta-analysis extension statementSpecific patient populationsStudy treatment armsConsiderable clinical heterogeneityPreferred Reporting ItemsRisk of performance