1982
Malignant lymphoma II. Prognostic factors and response to treatment of 473 patients at the national cancer institute
Anderson T, Devita V, Simon R, Berard C, Canellos G, Garvin A, Young R. Malignant lymphoma II. Prognostic factors and response to treatment of 473 patients at the national cancer institute. Cancer 1982, 50: 2708-2721. PMID: 7139564, DOI: 10.1002/1097-0142(19821215)50:12<2708::aid-cncr2820501203>3.0.co;2-g.Peer-Reviewed Original ResearchConceptsHistologic typeDiffuse histologic typeComplete responseNational Cancer InstitutePrognostic factorsLymphoma patientsLymphocytic lymphomaCancer InstituteHigh complete response rateDiffuse lymphoma patientsModern radiotherapeutic techniquesNodular lymphocytic lymphomaNodular lymphoma patientsSimilar treatment regimensComplete response rateImportant prognostic factorStage of diseaseCS ICS IIICS IVB symptomsCombination chemotherapyIV patientsHistologic subtypePatient sex
1980
Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations
Come S, Jaffe E, Andersen J, Mann R, Johnson B, DeVita V, Young R. Non-Hodgkin's lymphomas in leukemic phase: Clinicopathologic correlations. The American Journal Of Medicine 1980, 69: 667-674. PMID: 7001897, DOI: 10.1016/0002-9343(80)90416-7.Peer-Reviewed Original ResearchConceptsPeripheral blood involvementBlood involvementHistologic subtypeLeukemic phaseAdult lymphoblastic lymphomaDiffuse large cell lymphomaNon-Hodgkin lymphomaLarge cell lymphomaHomogeneous clinical pictureTypes of NHLLymphoblastic lymphomaRappaport classificationClinical pictureClinicopathologic entityHodgkin's lymphomaNodular lymphomaUnresponsive diseaseClinicopathologic correlationLymphocytic lymphomaClinical subtypesLeukemic conversionCell lymphomaCytologic featuresHigh riskPredominant cellsThe Rappaport classification of non-Hodgkin's lymphomas: a closer look using other proposed classifications.
Garvin A, Simon R, Young R, DeVita V, Berard C. The Rappaport classification of non-Hodgkin's lymphomas: a closer look using other proposed classifications. Seminars In Oncology 1980, 7: 234-43. PMID: 6998002.Peer-Reviewed Original ResearchConceptsLukes-Collins systemNon-Hodgkin's lymphomaLukes-CollinsClassification of non-Hodgkin's lymphomasClinical management of patientsAggressive combination chemotherapyDiffuse histiocytic lymphomaHomogeneous group of patientsManagement of patientsGroup of patientsB symptomsLymphocytic lymphomaCentroblastic-centrocyticCombination chemotherapyDiffuse lymphomaLymphoblastic lymphomaPlasmacytoid differentiationKiel classificationRappaport classificationNodular lymphomaHistiocytic lymphomaRetrospective reviewFollicular patternClinicopathologic entityYounger patients
1978
Randomized comparison of chemotherapy (CVP) and radiotherapy (TBI) in stage III–IV poorly differentiated lymphocytic lymphoma
Johnson R, Canellos G, Young R, Chabner B, DeVita V. Randomized comparison of chemotherapy (CVP) and radiotherapy (TBI) in stage III–IV poorly differentiated lymphocytic lymphoma. International Journal Of Radiation Oncology • Biology • Physics 1978, 4: 33. DOI: 10.1016/0360-3016(78)90617-x.Peer-Reviewed Original ResearchChemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma.
Johnson R, Canellos G, Young R, Chabner B, DeVita V. Chemotherapy (cyclophosphamide, vincristine, and prednisone) versus radiotherapy (total body irradiation) for stage III-IV poorly differentiated lymphocytic lymphoma. Journal Of The National Cancer Institute 1978, 62: 321-5. PMID: 580598.Peer-Reviewed Original ResearchConceptsTotal body irradiationTotal body irradiation patientsEvaluate new therapeutic approachesSurvival rateStage III-IVCandida sepsisDurable remissionsLymphocytic lymphomaBody irradiationMalignant lymphomaSevere granulocytopeniaMyeloproliferative disordersLate complicationsIII-IVChemotherapy complicationsInduction treatmentSurvival advantageNeurotoxic reactionsTherapeutic approachesLymphomaChemotherapyPatientsComplicationsRadiotherapySurvival
1977
Sequential staging in non-Hodgkin's lymphoma.
Chabner B, Johnson R, DeVita V, Canellos G, Hubbard S, Johnson S, Young R. Sequential staging in non-Hodgkin's lymphoma. Journal Of The National Cancer Institute 1977, 61: 993-7. PMID: 902262.Peer-Reviewed Original ResearchConceptsNon-Hodgkin's lymphomaInvolvement of bone marrowBone marrow biopsyDiffuse lymphocytic lymphomaType of lymphomaPortal lymph nodesNon-surgical phaseCompletion of stagingNegative lymphangiogramLymphocytic lymphomaMarrow biopsyPositive lymphangiogramHistiocytic lymphomaAbdominal nodesLiver biopsyLymph nodesBone marrowLymphomaPhase of stagingNodular typeStage IIIStage IPatientsResults of stagingLaparotomy
1975
The American Burkitt Lymphoma Registry: a progress report.
Levine P, Connelly R, Berard C, O'Connor G, Dorfman R, EASTON J, DeVita V. The American Burkitt Lymphoma Registry: a progress report. Annals Of Internal Medicine 1975, 83: 31-6. PMID: 1147436, DOI: 10.7326/0003-4819-83-1-31.Peer-Reviewed Original ResearchConceptsLymphoma RegistryAfrican patientsAmerican patientsBurkitt's lymphomaEpstein-Barr virus titersPeripheral lymph node involvementAbrupt clinical presentationEpstein-Barr virus genomeHigh-dose cyclophosphamideLymph node involvementAmerican Burkitt's lymphomaCentral nervous systemPredominance of menPathologic reviewClinical presentationLymphocytic lymphomaAbsence of casesNonendemic regionsGastrointestinal tractNervous systemLymphomaPatientsVirus titersMore casesTime-space clusteringResults of combination chemotherapy of non-Hodgkin's lymphoma.
Schein P, Chabner B, Canellos G, Young R, Berard C, DeVita V. Results of combination chemotherapy of non-Hodgkin's lymphoma. British Journal Of Cancer. Supplement 1975, 2: 465-73. PMID: 1101932, PMCID: PMC2149606.Peer-Reviewed Original ResearchConceptsComplete remissionHodgkin's lymphomaCombination chemotherapyHistological subgroupsLymphocytic lymphomaMonths of treatmentDiffuse histiocytic lymphomaMOPP chemotherapyMedian durationLate recurrenceLymph nodesNodular histologyHistiocytic lymphomaRemissionExtended survivalBone marrowClinical validityLymphomaAdvanced stageChemotherapyPatientsRelapseInitial siteMonthsSurvivalTherapy of advanced lymphocytic lymphoma a preliminary report of a randomized trial between combination chemotherapy (CVP) and intensive radiotherapy.
Canellos G, DeVita V, Young R, Chabner B, Schein P, Johnson R. Therapy of advanced lymphocytic lymphoma a preliminary report of a randomized trial between combination chemotherapy (CVP) and intensive radiotherapy. British Journal Of Cancer. Supplement 1975, 2: 474-80. PMID: 1101933, PMCID: PMC2149565.Peer-Reviewed Original ResearchPercutaneous liver biopsy, peritoneoscopy and laparotomy: an assessment of relative merits in the lymphomata.
Chabner B, Johnson R, Chretien P, Schein P, Young R, Canellos C, Hubbard S, Anderson T, Rosenoff S, DeVita V. Percutaneous liver biopsy, peritoneoscopy and laparotomy: an assessment of relative merits in the lymphomata. British Journal Of Cancer. Supplement 1975, 2: 242-7. PMID: 126693, PMCID: PMC2149568.Peer-Reviewed Original ResearchConceptsPercutaneous liver biopsyLiver biopsyLymphocytic lymphomaUntreated patientsHodgkin's lymphomaPercutaneous liver biopsy specimensStage IV diseaseConsecutive untreated patientsWedge liver biopsyLiver biopsy specimensLiver involvementPositive biopsiesBiopsy specimensPercutaneous biopsyLaparotomyPatientsBiopsyLymphomaPositive findingsTwo-thirdsFindingsDiseaseLiverNon‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy
Schein P, Chabner B, Canellos G, Young R, Devita V. Non‐Hodgkin's lymphoma: Patterns of relapse from complete remission after combination chemotherapy. Cancer 1975, 35: 354-357. PMID: 1089470, DOI: 10.1002/1097-0142(197502)35:2<354::aid-cncr2820350209>3.0.co;2-2.Peer-Reviewed Original ResearchConceptsDiffuse histiocytic lymphomaComplete remissionLymphocytic lymphomaCombination chemotherapyHistiocytic lymphomaExtended disease-free survivalDisease-free survivalPatterns of relapseMonths of treatmentMaintenance chemotherapyRemission inductionLymph nodesLate recurrenceHistologic subgroupsHodgkin's lymphomaRemissionBone marrowLymphomaChemotherapyAggressive attemptsPatientsRelapseInitial siteTreatmentRecurrence
1974
Clinical antitumor activity and toxicity of streptozotocin (NSC‐85998)
Schein P, O'Connell M, Blom J, Hubbard S, Magrath I, Bergevin P, Wiernik P, Ziegler J, Devita V. Clinical antitumor activity and toxicity of streptozotocin (NSC‐85998). Cancer 1974, 34: 993-1000. PMID: 4371075, DOI: 10.1002/1097-0142(197410)34:4<993::aid-cncr2820340404>3.0.co;2-t.Peer-Reviewed Original ResearchConceptsMalignant carcinoid tumorsNormal renal functionIslet cell carcinomaClinical antitumor activityAcute lymphocytic leukemiaToxicity of streptozotocinHematologic toxicityAdvanced malignanciesRenal damageRenal functionCarcinoid tumorsHodgkin's diseaseCell carcinomaLymphocytic lymphomaTherapeutic responseLymphocytic leukemiaTumor massBurkitt's lymphomaDrug effectsMaximum dosesPatientsTotal doseStreptozotocinLymphomaAntitumor activity
1973
Diagnosis of liver involvement by lymphoma: Results in 96 consecutive peritoneoscopies
Bagley C, Thomas L, Johnson R, Chretien P, Devita V. Diagnosis of liver involvement by lymphoma: Results in 96 consecutive peritoneoscopies. Cancer 1973, 31: 840-847. PMID: 4267529, DOI: 10.1002/1097-0142(197304)31:4<840::aid-cncr2820310412>3.0.co;2-w.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseHepatic involvementLiver biopsyPositive biopsiesHodgkin's lymphomaLymphocytic lymphomaMultiple liver biopsiesMultiple needle biopsiesPresence of hepatomegalyLiver function testsPercutaneous liver biopsyUntreated Hodgkin's diseaseFrequent false-negative resultsPresence of symptomsFalse-negative resultsLiver involvementNodal diseaseWedge biopsyLymphomatous involvementFunction testsMinimal morbidityNeedle biopsyPercutaneous biopsySame patientBiopsy