2020
A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth
Galderisi A, Tricò D, Pierpont B, Shabanova V, Samuels S, Man C, Galuppo B, Santoro N, Caprio S. A Reduced Incretin Effect Mediated by the rs7903146 Variant in the TCF7L2 Gene Is an Early Marker of β-Cell Dysfunction in Obese Youth. Diabetes Care 2020, 43: 2553-2563. PMID: 32788279, PMCID: PMC7510033, DOI: 10.2337/dc20-0445.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAllelesBiomarkersEarly DiagnosisFemaleGenotypeGlucose IntoleranceGlucose Tolerance TestHumansIncretinsInsulinInsulin ResistanceInsulin SecretionInsulin-Secreting CellsMalePancreatic DiseasesPediatric ObesityPolymorphism, Single NucleotideTranscription Factor 7-Like 2 ProteinYoung AdultConceptsOral glucose tolerance testIncretin effectRs7903146 variantObese youthVariant rs7903146Obese adolescentsHyperglycemic clampInsulin sensitivityInsulin secretionC-peptide secretion rateIsoglycemic intravenous glucose infusionGlucose-induced insulin secretionImpaired glucose toleranceMetabolic phenotypeGlucose tolerance testLower insulin secretionPlasma glucose peakIntravenous glucose infusionΒ-cell functionPlasma glucose concentrationΒ-cell dysfunctionT risk alleleTranscription factor 7Wild-type genotypeIncretin response
2010
High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation
O’Malley G, Santoro N, Northrup V, D’Adamo E, Shaw M, Eldrich S, Caprio S. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010, 53: 1199-1209. PMID: 20204321, DOI: 10.1007/s00125-010-1693-0.Peer-Reviewed Original ResearchConceptsBeta-cell functionPlasma glucosePlasma glucose levelsInsulin sensitivityObese youthGlucose levelsType 2 diabetes mellitusConclusions/interpretationThese dataAdverse cardiovascular profileAims/hypothesisAImpaired glucose toleranceCell functionBMI z-scoreCross-sectional analysisAUC 2Standard OGTTCardiovascular profileDiabetes mellitusGlucose toleranceH glucoseInsulin resistanceRisk factorsInterpretationThese dataCardiovascular diseaseCell dysregulation