2021
Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial.
Faustino EVS, Raffini LJ, Hanson SJ, Cholette JM, Pinto MG, Li S, Kandil SB, Nellis ME, Shabanova V, Silva CT, Tala JA, McPartland T, Spinella PC. Age-Dependent Heterogeneity in the Efficacy of Prophylaxis With Enoxaparin Against Catheter-Associated Thrombosis in Critically Ill Children: A Post Hoc Analysis of a Bayesian Phase 2b Randomized Clinical Trial. Critical Care Medicine 2021, 49: e369-e380. PMID: 33566465, PMCID: PMC7979442, DOI: 10.1097/ccm.0000000000004848.Peer-Reviewed Original ResearchConceptsCentral venous catheter-associated deep venous thrombosisCatheter-associated deep venous thrombosisCentral venous cathetersEfficacy of prophylaxisDeep venous thrombosisAge-dependent heterogeneityAnti-Xa levelsVenous cathetersVenous thrombosisFactor VIII activityThrombin generationPlatelet countClinical trialsIll childrenPhase 2bVIII activityLow factor VIII activityCatheter-Associated ThrombosisInternational units/mLMinimum platelet countOlder childrenCritically Ill ChildrenEndogenous thrombin potentialHigher platelet countsPost Hoc Analysis
2020
Umbilical catheter-associated complications in a level IV neonatal intensive care unit
Levit OL, Shabanova V, Bizzarro MJ. Umbilical catheter-associated complications in a level IV neonatal intensive care unit. Journal Of Perinatology 2020, 40: 573-580. PMID: 31911645, DOI: 10.1038/s41372-019-0579-3.Peer-Reviewed Original ResearchConceptsNeonatal intensive care unitIntensive care unitLevel IV neonatal intensive care unitCatheter-associated complicationsUmbilical arterial catheterUmbilical cathetersCare unitCatheter useArterial catheterArterial catheter useUmbilical venous catheterVenous catheter useObservational cohort studyCatheter dwell timeCohort studyComplication rateCumulative incidenceVenous cathetersCox regressionResultsFifty-oneComplicationsCatheterEvent ratesSignificant riskLower percentage