Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents
D'Adamo E, Cali AM, Weiss R, Santoro N, Pierpont B, Northrup V, Caprio S. Central Role of Fatty Liver in the Pathogenesis of Insulin Resistance in Obese Adolescents. Diabetes Care 2010, 33: 1817-1822. PMID: 20668154, PMCID: PMC2909068, DOI: 10.2337/dc10-0284.Peer-Reviewed Original ResearchConceptsObese adolescentsFatty liverHFF groupVisceral fatLower whole-body insulin sensitivity indexTwo-step hyperinsulinemic-euglycemic clampWhole-body insulin sensitivity indexOral glucose tolerance testBaseline fatty acidsHepatic glucose production rateLow-dose insulinAbdominal fat distributionGlucose disposal rateIntramyocellular lipid contentGlucose tolerance testBeta-cell functionHyperinsulinemic-euglycemic clampInsulin sensitivity indexBMI z-scoreHepatic fat contentInsulin-resistant statesMagnetic resonance imagingSuppression of EGPGlucose production rateInsulin resistanceHigh normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation
O’Malley G, Santoro N, Northrup V, D’Adamo E, Shaw M, Eldrich S, Caprio S. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010, 53: 1199-1209. PMID: 20204321, DOI: 10.1007/s00125-010-1693-0.Peer-Reviewed Original ResearchConceptsBeta-cell functionPlasma glucosePlasma glucose levelsInsulin sensitivityObese youthGlucose levelsType 2 diabetes mellitusConclusions/interpretationThese dataAdverse cardiovascular profileAims/hypothesisAImpaired glucose toleranceCell functionBMI z-scoreCross-sectional analysisAUC 2Standard OGTTCardiovascular profileDiabetes mellitusGlucose toleranceH glucoseInsulin resistanceRisk factorsInterpretationThese dataCardiovascular diseaseCell dysregulation