2025
Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing
Katsafadou A, Prodromou S, Aalizadeh R, White J, Thomaidis N, Vizirianakis I, Anastas P, Kyriakides T, Pastides H, Piscitelli P, Colao A, Thompson D, Vasiliou V. Olive tree at the intersection of environment, public health, and One Health: a sustainable path to global wellbeing. Frontiers In Public Health 2025, 13: 1658525. DOI: 10.3389/fpubh.2025.1658525.Peer-Reviewed Original ResearchOlive treesEnvironmental impactHuman healthOlive by-productsClimate change mitigationHealth benefitsSustainable agricultural practicesHuman health benefitsMonounsaturated fatty acidsOlive sectorGreenhouse gas emissionsBiodiversity supportEcosystem stewardshipBy-productsFeed additivesOlive oil cultivationAnimal nutritionCarbon sequestrationSoil conservationOlive oil productionSustainable agricultureFood productsLivestock healthAntioxidant propertiesEcological sustainabilityBringing our genomes to medicine – the 2026 human genome meeting
Patrinos G, Reichardt J, Carninci P, Hamosh A, Mitropoulou C, Vasiliou V. Bringing our genomes to medicine – the 2026 human genome meeting. Human Genomics 2025, 19: 93. PMID: 40813697, PMCID: PMC12355788, DOI: 10.1186/s40246-025-00804-y.Peer-Reviewed Original ResearchDoes my patient need testing for PFAS ‘forever chemicals’?
Zuccaro P, Valvi D, Vasiliou V. Does my patient need testing for PFAS ‘forever chemicals’? Cleveland Clinic Journal Of Medicine 2025, 92: 463-465. PMID: 40750320, DOI: 10.3949/ccjm.92a.24082.Peer-Reviewed Original ResearchSynergistic toxicity in alcohol-associated liver disease and PFAS exposure
Stem A, Tieghi R, Chatzi V, Kleinstreuer N, Valvi D, Thompson D, Vasiliou V. Synergistic toxicity in alcohol-associated liver disease and PFAS exposure. Toxicological Sciences 2025, kfaf110. PMID: 40737496, DOI: 10.1093/toxsci/kfaf110.Peer-Reviewed Original ResearchAlcohol-associated liver diseaseLiver diseaseChronic ethanol intakeCentral mechanismsHepatotoxic effectsPolyfluoroalkyl substancesHigh-risk populationOxidative stressDysregulated lipid metabolismEthanol intakeLiver functionLiver injuryAcetaldehyde-induced cytotoxicityHepatic functionHepatocellular damageOxidative stress inductionLiver pathologyGlobal morbidityPathogenic pathwaysPolyfluoroalkyl substances exposuresExposure to polyfluoroalkyl substancesFatty acid oxidationHealthcare accessEffects of polyfluoroalkyl substancesMultiple mechanismsIntegrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy
Koutromanos I, Legaki E, Dovrolis N, Vassilopoulos E, Stem A, Vasiliou V, Tzavellas E, Gazouli M. Integrating gut microbiome and neuroplasticity genomics in alcohol use disorder therapy. Human Genomics 2025, 19: 78. PMID: 40646629, PMCID: PMC12255058, DOI: 10.1186/s40246-025-00793-y.Peer-Reviewed Original ResearchConceptsGut microbiotaShort-chain fatty acid (SCFA)-producing bacteriaMetabolic pathwaysStress-related metabolic pathwaysHost-microbiota interactionsMicrobial metabolic pathwaysMulti-omics approachGut barrier integrityGene expression changesGene expression profilesNeuroplasticity-related genesRRNA sequencingGut microbiomeFamily genesGenomic signaturesMicrobiome compositionMicrobial compositionAUD patientsMicrobial dysbiosisTreatment responseFunctional pathwaysGene expressionMicrobiomeGenesExpression changesLessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health
Lisgara A, Thompson D, Nebert D, Vasiliou V. Lessons learned from aldehyde dehydrogenases as non-P450 aldehyde-oxidizing enzymes: implications for the ‘exposome’ and human health. Expert Opinion On Drug Metabolism & Toxicology 2025, 21: 915-919. PMID: 40591371, DOI: 10.1080/17425255.2025.2524872.Peer-Reviewed Original ResearchConceptsAldehyde dehydrogenaseAldehyde-oxidizing enzymesNon-P450ALDH superfamilyNitric oxide-related speciesEnzymatic diversityGenetic screeningALDH polymorphismsCytochrome P450 enzymesRedox balancePrecise risk assessmentNeurodegenerative diseasesEnvironmental stressorsClinical implicationsDetoxication functionEnzymeP450 enzymesLifetime environmental exposuresTherapeutic targetPolymorphismCellular damageDehydrogenaseEnvironmental exposuresClinical relevanceHuman healthUpdate of the sideroflexin (SLC56) gene family
Katsafadou A, Nebert D, Krupenko S, Thompson D, Vasiliou V. Update of the sideroflexin (SLC56) gene family. Human Genomics 2025, 19: 69. PMID: 40542427, PMCID: PMC12180156, DOI: 10.1186/s40246-025-00779-w.Peer-Reviewed Original ResearchConceptsIron-sulfur cluster assemblyMitochondrial iron-regulatedMitochondrial iron homeostasisMitochondrial serine transporterMitochondrial transmembrane proteinOxidative phosphorylation disordersSolute carrier familyEukaryotic speciesOne-carbon metabolismMitochondrial researchGene familyModel organismsCellular homeostasisEvolutionary trajectoriesMitochondrial metabolismTransmembrane domainCongenital sideroblastic anemiaTransmembrane proteinsCarrier familySideroflexinHeme biosynthesisIron regulationCitrate metabolismMitochondrial functionSerine transportHuman Genomics Brief Reports: embracing concise dissemination for rapid and impactful discoveries
Vasiliou V, Reichardt J, Ali B. Human Genomics Brief Reports: embracing concise dissemination for rapid and impactful discoveries. Human Genomics 2025, 19: 64. PMID: 40481586, PMCID: PMC12144796, DOI: 10.1186/s40246-025-00777-y.Peer-Reviewed Original ResearchDesigning Ultraporous Mesostructured Silica Nanoparticles for the Remediation of Per- and Polyfluoroalkyl Substances
Huang C, Lewis R, Thomas S, Tang Z, Jones J, Nason S, Zuverza-Mena N, Piskulich Z, O’Keefe T, Tuga B, Paredes-Beaulieu A, Vasiliou V, Cui Q, Dalluge J, White J, Haynes C. Designing Ultraporous Mesostructured Silica Nanoparticles for the Remediation of Per- and Polyfluoroalkyl Substances. ACS Nano 2025, 19: 19777-19789. PMID: 40402145, DOI: 10.1021/acsnano.5c02008.Peer-Reviewed Original ResearchConceptsMesostructured silica nanoparticlesPFAS moleculesMolecular dynamics simulationsPolyfluoroalkyl substancesLiquid chromatography-tandem mass spectrometryChromatography-tandem mass spectrometrySilica nanoparticlesNitrogen physisorptionDynamic light scatteringSilica surfaceMass spectrometryDynamics simulationsFunctional groupsUptake of PFASsElectrostatic interactionsChain lengthRemediation of per-PFAS uptakeLC-MS/MSMultiple PFASLight scatteringPromote phytoremediationRemediation strategiesEnvironmental matricesNanoparticlesAdvancing translational exposomics: bridging genome, exposome and personalized medicine
Sarigiannis D, Karakitsios S, Anesti O, Stem A, Valvi D, Sumner S, Chatzi L, Snyder M, Thompson D, Vasiliou V. Advancing translational exposomics: bridging genome, exposome and personalized medicine. Human Genomics 2025, 19: 48. PMID: 40307849, PMCID: PMC12044731, DOI: 10.1186/s40246-025-00761-6.Peer-Reviewed Original ResearchConceptsExposome-wide association studyBridge genomicsLifestyle exposuresEnhancing causal inferencePublic health decision-makingEnvironmental health researchHealth decision-makingMulti-omics technologiesGenomic variationGenomic dataAssociation studiesHealth outcomesBioinformatics approachHealth researchPrecision preventionGenetic variabilityExposome dataExposure-response relationshipMulti-OmicsGenomeInternal exposomeVulnerable populationsComplex diseasesDisease phenotypePublic health4.09 Aldehyde Dehydrogenases
Vasiliou V, Lisgara A, Krupenko S, Krupenko N, Alayyoub M, Petersen D, Thompson D. 4.09 Aldehyde Dehydrogenases. 2025, 183-210. DOI: 10.1016/b978-0-323-95488-4.00287-4.Peer-Reviewed Original ResearchAldehyde dehydrogenaseTransgenic knockout mouse modelLate-onset Alzheimer's diseaseAldehyde dehydrogenase superfamilyAldehyde dehydrogenase geneNAD(P)+-dependent enzymesType II hyperprolinemiaHuman genomeDehydrogenase geneKnockout mouse modelPoor cancer prognosisExogenous aldehydesMolecular basisSpastic paraplegiaPhysiological processesAlzheimer's diseaseDe Barsy syndromeClinical phenotypeSjogren-Larsson syndromeGenesCancer stem cellsDehydrogenaseEnzyme inactivationEnzymeBarsy syndrome
2024
CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study
Wang Y, Charkoftaki G, Orlicky D, Davidson E, Aalizadeh R, Sun N, Ginsberg G, Thompson D, Vasiliou V, Chen Y. CYP2E1 in 1,4-dioxane metabolism and liver toxicity: insights from CYP2E1 knockout mice study. Archives Of Toxicology 2024, 98: 3241-3257. PMID: 39192018, PMCID: PMC11500436, DOI: 10.1007/s00204-024-03811-5.Peer-Reviewed Original ResearchCYP2E1-null miceLiver toxicityDrinking waterOxidative DNA damageLiver carcinogenAbstract1,4-DioxaneDNA damage repair responseImpaired DNA damage repairWater contaminationOxidative stressElevated oxidative stressEnvironmental pollutionKnockout mouse studiesDamage repair responseCYP2E1-nullMale wildtypeWT miceDNA damageDX exposureRisk assessmentRedox dysregulationCYP2E1 inductionLiver oxidative stressHigh dosesMouse studiesGlutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression
Asantewaa G, Tuttle E, Ward N, Kang Y, Kim Y, Kavanagh M, Girnius N, Chen Y, Rodriguez K, Hecht F, Zocchi M, Smorodintsev-Schiller L, Scales T, Taylor K, Alimohammadi F, Duncan R, Sechrist Z, Agostini-Vulaj D, Schafer X, Chang H, Smith Z, O’Connor T, Whelan S, Selfors L, Crowdis J, Gray G, Bronson R, Brenner D, Rufini A, Dirksen R, Hezel A, Huber A, Munger J, Cravatt B, Vasiliou V, Cole C, DeNicola G, Harris I. Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression. Nature Communications 2024, 15: 6152. PMID: 39034312, PMCID: PMC11271484, DOI: 10.1038/s41467-024-50454-2.Peer-Reviewed Original ResearchConceptsGlutamate-cysteine ligase catalytic subunitLipid abundanceLipogenic enzyme expressionAbundance in vivoLipid productionCatalytic subunitRepress Nrf2Transcription factorsNrf2 repressionAdult tissuesSynthesis of GSHEnzyme expressionNon-redundantRedox bufferMouse liverLoss of GSHTriglyceride productionIn vivo modelsAbundanceGlutathione synthesisLiver balanceFat storesOxidative stressLipidDeletionA Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation
Bonetti L, Horkova V, Grusdat M, Longworth J, Guerra L, Kurniawan H, Franchina D, Soriano-Baguet L, Binsfeld C, Verschueren C, Spath S, Ewen A, Koncina E, Gérardy J, Kobayashi T, Dostert C, Farinelle S, Härm J, Fan Y, Chen Y, Harris I, Lang P, Vasiliou V, Waisman A, Letellier E, Becher B, Mittelbronn M, Brenner D. A Th17 cell-intrinsic glutathione/mitochondrial-IL-22 axis protects against intestinal inflammation. Cell Metabolism 2024, 36: 1726-1744.e10. PMID: 38986617, DOI: 10.1016/j.cmet.2024.06.010.Peer-Reviewed Original ResearchReactive oxygen speciesMitochondrial functionCatalytic subunit of glutamate cysteine ligaseMitochondrial gene expressionDecreased cellular ATPPhosphorylation of 4E-BP1Disrupt mitochondrial functionReduced phosphorylation of 4E-BP1T cell-specific ablationCell's antioxidant mechanismsCell-specific ablationCatalytic subunitIL-22Cellular signalingIntestinal homeostasisIL-22 productionSignificant reactive oxygen speciesSubunit of glutamate cysteine ligaseGene expressionReduced IL-22 productionReduced phosphorylationCellular ATPGut protectionProtein synthesisGlutamate cysteine ligaseHepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants
Prodromou S, Chatzopoulou F, Saiti A, Giannopoulos-Dimitriou A, Koudoura L, Pantazaki A, Chatzidimitriou D, Vasiliou V, Vizirianakis I. Hepatotoxicity assessment of innovative nutritional supplements based on olive-oil formulations enriched with natural antioxidants. Frontiers In Nutrition 2024, 11: 1388492. PMID: 38812942, PMCID: PMC11133736, DOI: 10.3389/fnut.2024.1388492.Peer-Reviewed Original ResearchNutritional supplementsLong-term effects of oxidative stressOxidative stressCell culturesReal-time PCRNatural antioxidantsEvaluate cell viabilityGene expression profilesPotential nutritional supplementEffects of oxidative stressHepG2 cell culturesMolecular pathophysiologyTherapeutic strategiesQuantitative real-time PCRInflammatory signalingAlleviate symptomsAlzheimer's diseaseLong-term effectsLong-term consequencesProliferation capacityMolecular pathwaysCell toxicityDelivery modeCellular toxicityOlive-oilLong-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study
Ma X, Fisher J, McGlynn K, Liao L, Vasiliou V, Sun N, Kaufman J, Silverman D, Jones R. Long-term exposure to ambient fine particulate matter and risk of liver cancer in the NIH-AARP Diet and Health Study. Environment International 2024, 187: 108637. PMID: 38636274, PMCID: PMC11286199, DOI: 10.1016/j.envint.2024.108637.Peer-Reviewed Original ResearchConceptsRisk of liver cancerIncreased risk of liver cancerFine particulate matterNIH-AARP DietNIH-AARPParticulate matterHistorical PM2.5 concentrationsOutdoor PM2.5 levelsAmbient PM2.5 levelsLong-term exposure to ambient fine particulate matterHealth StudyExposure to ambient fine particulate matterAmbient fine particulate matterAssociated with liver cancer riskYears prior to cancer diagnosisEvidence of effect modificationLiver cancer riskLiver cancer incidenceIncreased riskSpatiotemporal prediction modelAmbient PM2.5 levelsPM2.5 levelsHistorical exposure assessmentBody mass indexPhysical activityA comprehensive trial on PFAS remediation: hemp phytoextraction and PFAS degradation in harvested plants
Nason S, Thomas S, Stanley C, Silliboy R, Blumenthal M, Zhang W, Liang Y, Jones J, Zuverza-Mena N, White J, Haynes C, Vasiliou V, Timko M, Berger B. A comprehensive trial on PFAS remediation: hemp phytoextraction and PFAS degradation in harvested plants. Environmental Science Advances 2024, 3: 304-313. PMID: 38322792, PMCID: PMC10841816, DOI: 10.1039/d3va00340j.Peer-Reviewed Original ResearchPolyfluoroalkyl substancesRemoval of contaminantsPFAS-contaminated soilDegradation of polyfluoroalkyl substancesRemove PFASDegrade polyfluoroalkyl substancesExtractable organic fluorinePFAS remediationShorter-chain compoundsPFAS degradationRemediation optionsSoil samplesToxic contaminantsPFAS concentrationsPhytoremediationSoilPFAS levelsHarvested plantsHemp tissuesLonger-chainField trialsSulfonic acidContaminationRemediationOrganic fluorineThe European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit
Zuccaro P, Thompson D, de Boer J, Llompart M, Watterson A, Bilott R, Birnbaum L, Vasiliou V. The European Union Ban on Microplastics Includes Artificial Turf Crumb Rubber Infill: Other Nations Should Follow Suit. Environmental Science And Technology 2024, 58: 2591-2594. PMID: 38301275, DOI: 10.1021/acs.est.4c00047.Peer-Reviewed Original ResearchEditorial overview: Unveiling 1,4-dioxane's multifaceted dimensions through a special collection
Vasiliou V. Editorial overview: Unveiling 1,4-dioxane's multifaceted dimensions through a special collection. Current Opinion In Environmental Science & Health 2024, 37: 100519. DOI: 10.1016/j.coesh.2023.100519.Peer-Reviewed Original ResearchCelebrating 20 years of human genomics: a journey of discovery
Vasiliou V. Celebrating 20 years of human genomics: a journey of discovery. Human Genomics 2024, 18: 1. PMID: 38163870, PMCID: PMC10759603, DOI: 10.1186/s40246-023-00569-2.Peer-Reviewed Original Research
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