2016
Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism
Kim KE, Jung Y, Min S, Nam M, Heo RW, Jeon BT, Song DH, Yi CO, Jeong EA, Kim H, Kim J, Jeong SY, Kwak W, Ryu do H, Horvath TL, Roh GS, Hwang GS. Caloric restriction of db/db mice reverts hepatic steatosis and body weight with divergent hepatic metabolism. Scientific Reports 2016, 6: 30111. PMID: 27439777, PMCID: PMC4954985, DOI: 10.1038/srep30111.Peer-Reviewed Original ResearchConceptsNon-alcoholic fatty liver diseaseDb/db miceDb miceEffects of CRCaloric restrictionLiver diseaseHepatic steatosisHepatic metabolismObese diabetic db/db miceBody weightDiabetic db/db miceFatty liver diseaseObesity-related diseasesInflammation-related proteinsSignificant metabolic alterationsMultiple pathological mechanismsEndoplasmic reticulum stressWestern blot analysisMultiple complicationsInsulin resistanceLipocalin-2Metabolic dysfunctionTherapeutic effectFrequent causeClinical problem
2013
Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance
Schneeberger M, Dietrich MO, Sebastián D, Imbernón M, Castaño C, Garcia A, Esteban Y, Gonzalez-Franquesa A, Rodríguez IC, Bortolozzi A, Garcia-Roves PM, Gomis R, Nogueiras R, Horvath TL, Zorzano A, Claret M. Mitofusin 2 in POMC Neurons Connects ER Stress with Leptin Resistance and Energy Imbalance. Cell 2013, 155: 172-187. PMID: 24074867, PMCID: PMC3839088, DOI: 10.1016/j.cell.2013.09.003.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEndoplasmic Reticulum StressGTP PhosphohydrolasesHypothalamusLeptinMiceMice, Inbred C57BLNeuronsObesityPro-OpiomelanocortinConceptsHypothalamic ER stressER stress-induced leptin resistanceLeptin resistanceMitofusin 2ER stressMitochondria-endoplasmic reticulum interactionAnorexigenic pro-opiomelanocortin (POMC) neuronsPro-opiomelanocortin (POMC) neuronsDiet-induced obesityMitochondria-ER contactsSystemic energy balancePOMC neuronsMetabolic alterationsCausative factorsEnergy expenditurePOMC processingObesityUnderlying mechanismCrucial involvementNeuronsEnergy imbalanceEssential regulatorCritical roleHyperphagiaHypothalamus