2016
Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis
Jin S, Kim JG, Park JW, Koch M, Horvath TL, Lee BJ. Hypothalamic TLR2 triggers sickness behavior via a microglia-neuronal axis. Scientific Reports 2016, 6: 29424. PMID: 27405276, PMCID: PMC4942617, DOI: 10.1038/srep29424.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnorexiaArcuate Nucleus of HypothalamusCyclooxygenase InhibitorsEnergy MetabolismFeverInflammationLipopeptidesMaleMiceMice, KnockoutMicrogliaMyeloid Differentiation Factor 88NF-kappa BPro-OpiomelanocortinRatsReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Toll-Like Receptor 2Weight LossConceptsSickness behaviorHypothalamic inflammationToll-like receptor 2 (TLR2) activationSickness behavior symptomsNuclear factor kappa BBody weight lossReceptor 2 activationFactor kappa BNeuronal circuit functionHypothalamic microgliaProopiomelanocortin neuronsInflammatory mechanismsIntracerebroventricular injectionPathophysiologic mechanismsTLR2 activationInflammatory processCyclooxygenase pathwayNeuronal activationKappa BBehavior symptomsWeight lossInput organizationMicrogliaTLR2Inflammation
2006
Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake
Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, Mountjoy KG, Clifton PG, Lowell BB, Friedman JM, Horvath T, Butler AA, Elmquist JK, Cowley MA. Serotonin Reciprocally Regulates Melanocortin Neurons to Modulate Food Intake. Neuron 2006, 51: 239-249. PMID: 16846858, DOI: 10.1016/j.neuron.2006.06.004.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsEatingElectric StimulationMaleMiceMice, Inbred AMice, Inbred C57BLMice, KnockoutMice, ObeseMice, TransgenicNerve NetNeuronsPyridinesReceptor, Melanocortin, Type 3Receptor, Melanocortin, Type 4Receptor, Serotonin, 5-HT1BReceptors, MelanocortinSerotoninSerotonin 5-HT1 Receptor AgonistsConceptsFood intakePeripheral adiposity signalsBody weight homeostasisCentral serotonergic systemMelanocortin receptor agonistModulates food intakeSerotonin1B receptorsMelanocortin neuronsWeight homeostasisMelanocortin-3Receptor agonistSerotonergic regulationAdiposity signalsSerotonergic systemEndogenous releaseMelanocortin-4Central circuitryBody weightNeural pathwaysMelanocortin receptorsReceptorsDownstream activationAgonistsAntagonistIntake