2024
Kisspeptin signaling in astrocytes modulates the reproductive axis
Torres E, Pellegrino G, Granados-Rodríguez M, Fuentes-Fayos A, Velasco I, Coutteau-Robles A, Legrand A, Shanabrough M, Perdices-Lopez C, Leon S, Yeo S, Manchishi S, Sánchez-Tapia M, Navarro V, Pineda R, Roa J, Naftolin F, Argente J, Luque R, Chowen J, Horvath T, Prevot V, Sharif A, Colledge W, Tena-Sempere M, Romero-Ruiz A. Kisspeptin signaling in astrocytes modulates the reproductive axis. Journal Of Clinical Investigation 2024, 134: e172908. PMID: 38861336, PMCID: PMC11291270, DOI: 10.1172/jci172908.Peer-Reviewed Original ResearchResponse to metabolic stressProtein-protein interactionsMetabolic stressOntology analysisReproductive axisKisspeptin signalingGene expressionKisspeptin actionHypothalamic GnRH neuronsProteomic profilingFemale pubertal onsetReproductive modulesExpression of KISS1RLH secretory profilesSignaling-pathwayCellular co-expressionConditional ablationResponse to kisspeptinLH responses to kisspeptinNon-neuronal pathwaysAstrocytes in vivoHigh-fat dietGFAP-positive cellsPathwayReproductive control
2008
Cross-talk between estrogen and leptin signaling in the hypothalamus
Gao Q, Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus. AJP Endocrinology And Metabolism 2008, 294: e817-e826. PMID: 18334610, DOI: 10.1152/ajpendo.00733.2007.Peer-Reviewed Original ResearchConceptsAdipocyte-secreted hormone leptinGonadal steroid hormone estrogenAction of leptinMajor risk factorNeuroendocrine reproductive axisEnergy expenditureHalf of adultsSteroid hormone estrogenEnhanced food intakeFunction of estrogenEstrogen deficiencyRisk factorsHormone leptinCardiovascular diseaseHormone estrogenFood intakeBody fatReproductive axisLeptinEstrogenRegulation of reproductionEnergy homeostasisWeight gainEstrogen facilitatesNeuroendocrine processes