2021
Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension
Gruber T, Pan C, Contreras RE, Wiedemann T, Morgan DA, Skowronski AA, Lefort S, De Bernardis Murat C, Le Thuc O, Legutko B, Ruiz-Ojeda FJ, de la Fuente-Fernández M, García-Villalón AL, González-Hedström D, Huber M, Szigeti-Buck K, Müller TD, Ussar S, Pfluger P, Woods SC, Ertürk A, LeDuc CA, Rahmouni K, Granado M, Horvath TL, Tschöp MH, García-Cáceres C. Obesity-associated hyperleptinemia alters the gliovascular interface of the hypothalamus to promote hypertension. Cell Metabolism 2021, 33: 1155-1170.e10. PMID: 33951475, PMCID: PMC8183500, DOI: 10.1016/j.cmet.2021.04.007.Peer-Reviewed Original ResearchConceptsBlood pressureObesity-associated increaseObesity-induced hypertensionElevated blood pressureSystemic blood pressureEndothelial growth factorHIF1α-VEGFArterial hypertensionNovel mechanistic linkSympathetic hyperactivityHemodynamic homeostasisHypothalamic astrocytesMetabolic syndromeRegion-specific lossMacrovascular systemsLeptin signalingBrain centersPathophysiological processesHypertensionGliovascular interfacePathway disruptionGrowth factorAstrocytesMechanistic linkAngiopathy
1999
Estrogen and microglia: A regulatory system that affects the brain
Mor G, Nilsen J, Horvath T, Bechmann I, Brown S, Garcia‐Segura L, Naftolin F. Estrogen and microglia: A regulatory system that affects the brain. Developmental Neurobiology 1999, 40: 484-496. PMID: 10453051, DOI: 10.1002/(sici)1097-4695(19990915)40:4<484::aid-neu6>3.0.co;2-c.Peer-Reviewed Original ResearchConceptsSex hormonesRat microglial cellsSecretion of cytokinesPresence of estrogenGlial cell typesMicroglial functionEstrogen actionMicroglial cellsGonadal steroidsGlial cellsSteroid actionNeuroendocrine eventsMicrogliaPresent review detailsGrowth factorEstrogenBrainPhysiological regulationHormoneCell typesReview detailsNew studiesRegulatory actionCellsRegulatory functions
1998
Tracing of the entorhinal‐hippocampal pathway in vitro
Kluge A, Hailer N, Horvath T, Bechmann I, Nitsch R. Tracing of the entorhinal‐hippocampal pathway in vitro. Hippocampus 1998, 8: 57-68. PMID: 9519887, DOI: 10.1002/(sici)1098-1063(1998)8:1<57::aid-hipo6>3.0.co;2-4.Peer-Reviewed Original ResearchConceptsOuter molecular layerPerforant pathDentate gyrusEntorhinal cortexEntorhinal-hippocampal interactionPerforant path axonsOrganotypic slice culturesMini-RubyPerforant fibersVitro tracingAnterograde degenerationDendritic shaftsLesion paradigmMicroglial cellsNeuronal degenerationEntorhinal neuronsNeurotoxin treatmentMolecular layerSlice culturesAxonal materialGrowth factorSubsequent phagocytosisGyrusEntorhinal-hippocampal regionFurther studies