2015
The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control
Varela L, Horvath T. The role of the hypothalamus in the maintenance of energy balance and peripheral glucose control. 2015, 529-537. DOI: 10.1002/9781118387658.ch36.Peer-Reviewed Original ResearchEnergy homeostasisPrevalence of obesityAnorectic hormonesAgRP neuronsHypothalamic POMCObese patientsGlucose controlGlucose homeostasisBody weightInsulin actionHormonal actionLeptinMajor targetInsulinHormoneBrainHomeostasisLatest findingsEnergy balanceSteady riseObesityPatientsHypothalamusPathwayPrevalence
2012
Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis
Varela L, Horvath TL. Leptin and insulin pathways in POMC and AgRP neurons that modulate energy balance and glucose homeostasis. EMBO Reports 2012, 13: 1079-1086. PMID: 23146889, PMCID: PMC3512417, DOI: 10.1038/embor.2012.174.Peer-Reviewed Original ResearchConceptsGlucose homeostasisEnergy homeostasisPrevalence of obesityWhole-body energy homeostasisBody energy homeostasisAnorectic hormonesAgRP neuronsObese patientsProtein (AgRP) neuronsCentral effectsHypothalamic proopiomelanocortinBody weightInsulin actionLeptinHormonal actionMajor targetInsulin pathwayHomeostasisInsulinNeuronsHormoneBrainLatest findingsEnergy balanceSteady rise
2008
Ghrelin: an orexigenic signal from the stomach
Horvath T. Ghrelin: an orexigenic signal from the stomach. 2008, 266-284. DOI: 10.1017/cbo9780511541643.010.Peer-Reviewed Original ResearchEffects of ghrelinGrowth hormone secretagoguesFood intakeGrowth hormoneGrowth hormone secretagogue receptorDiscovery of ghrelinAmino acid peptide hormoneAnorectic hormonesOrexigenic signalsGhrelin actionPeripheral mechanismsSecretagogue receptorMetabolic effectsHormone secretagoguesBody fatGhrelinPeripheral signalsEndogenous ligandStimulatory effectEnergy expenditurePeptide hormonesCell proliferationIntakeHormoneHormonal regulation