2019
Limited indirect effects of an infant pneumococcal vaccination program in an aging population
van der Linden M, Imöhl M, Perniciaro S. Limited indirect effects of an infant pneumococcal vaccination program in an aging population. PLOS ONE 2019, 14: e0220453. PMID: 31369597, PMCID: PMC6675109, DOI: 10.1371/journal.pone.0220453.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseSerotype 3 invasive pneumococcal diseaseHerd protection effectsIPD casesAge groupsPCV13-type invasive pneumococcal diseaseAdult invasive pneumococcal diseaseAdult pneumococcal vaccinationPneumococcal vaccination programAdults 60 yearsVaccine serotypes 4Years of ageAdult age groupsIndirect protection effectPneumococcal vaccinationPneumococcal diseasePolysaccharide vaccineVaccine recommendationsChildhood vaccinationVaccination programVaccine formulationsAdult coverageAdults 60Protection effectSerotype 4
2017
Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014
Imöhl M, Fitzner C, Perniciaro S, van der Linden M. Epidemiology and distribution of 10 superantigens among invasive Streptococcus pyogenes disease in Germany from 2009 to 2014. PLOS ONE 2017, 12: e0180757. PMID: 28719668, PMCID: PMC5515411, DOI: 10.1371/journal.pone.0180757.Peer-Reviewed Original ResearchConceptsSuperantigen genesEmm typesNationwide laboratory-based surveillance studyInvasive S. pyogenes infectionInvasive Streptococcus pyogenes diseaseSignificant associationLaboratory-based surveillance studyFrequent clinical manifestationsS. pyogenes infectionCommon emm typesProportion of isolatesClinical manifestationsClinical complicationsEmm 1Peritoneal fluidPyogenes infectionCerebrospinal fluidSurveillance studyEmm 28Synovial fluidEmm 89S. pyogenesType 3SpeJMost isolates
2015
Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany
van der Linden M, Falkenhorst G, Perniciaro S, Imöhl M. Effects of Infant Pneumococcal Conjugate Vaccination on Serotype Distribution in Invasive Pneumococcal Disease among Children and Adults in Germany. PLOS ONE 2015, 10: e0131494. PMID: 26132078, PMCID: PMC4488910, DOI: 10.1371/journal.pone.0131494.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overChildChild, PreschoolFemaleGenes, BacterialGermanyHeptavalent Pneumococcal Conjugate VaccineHumansImmunization ProgramsImmunologic SurveillanceInfantInfant, NewbornMaleMiddle AgedPneumococcal InfectionsPneumococcal VaccinesRNA, Ribosomal, 16SSerogroupSerotypingStreptococcus pneumoniaeVaccinationConceptsEarly vaccination periodPneumococcal conjugate vaccinationInvasive pneumococcal diseaseVaccination periodConjugate vaccinationPCV7 serotypesIPD casesPneumococcal diseaseQuellung methodSerotype distributionChildhood pneumococcal conjugate vaccinationNon-vaccinated age groupsAge groupsGerman National Reference CenterPre-vaccination periodSerotype 1Streptococcus pneumoniae isolatesNational Reference CenterMicrobiological diagnostic laboratorySerotype 10AInfant vaccinationVaccine serotypesSerotype 19ASeparate age groupsPneumoniae isolatesIncrease of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era
van der Linden M, Perniciaro S, Imöhl M. Increase of serotypes 15A and 23B in IPD in Germany in the PCV13 vaccination era. BMC Infectious Diseases 2015, 15: 207. PMID: 25940580, PMCID: PMC4424534, DOI: 10.1186/s12879-015-0941-9.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseasePenicillin non-susceptible isolatesNon-PCV13 serotypesNon-susceptible isolatesSerotype 15AVaccination periodSurveillance of IPDClonal complexesChildhood pneumococcal conjugate vaccinationGerman National Reference CenterEarly vaccination periodHigher-valent vaccinesPneumococcal conjugate vaccinationNational Reference CenterConclusionsThe prevalenceConjugate vaccinationSerotype 23BPneumococcal diseaseChildhood vaccinationVaccination eraSurveillance periodSerogroups 23BackgroundThis studyReference centerVaccination formulationsPneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany
Imöhl M, Möller J, Reinert R, Perniciaro S, van der Linden M, Aktas O. Pneumococcal meningitis and vaccine effects in the era of conjugate vaccination: results of 20 years of nationwide surveillance in Germany. BMC Infectious Diseases 2015, 15: 61. PMID: 25885764, PMCID: PMC4335684, DOI: 10.1186/s12879-015-0787-1.Peer-Reviewed Original ResearchConceptsInvasive pneumococcal diseaseMeningitis casesPneumococcal meningitisQuellung reactionGerman National Reference CenterNeufeld Quellung reactionPre-PCV7 periodPneumococcal conjugate vaccinePost-vaccination periodCase mortality rateNational Reference CenterAntibiotic nonsusceptibilityIPD isolatesPneumococcal diseaseVaccination recommendationsVaccine recommendationsConjugate vaccineVaccine serotypesBroth microdilution methodVaccine effectsNationwide surveillancePneumococcal isolatesSerotype prevalenceReference centerMortality rate