Bacterial Spectrum of Spontaneously Ruptured Otitis Media in a 7-Year, Longitudinal, Multicenter, Epidemiological Cross-Sectional Study in Germany
Imöhl M, Perniciaro S, Busse A, van der Linden M. Bacterial Spectrum of Spontaneously Ruptured Otitis Media in a 7-Year, Longitudinal, Multicenter, Epidemiological Cross-Sectional Study in Germany. Frontiers In Medicine 2021, 8: 675225. PMID: 34095179, PMCID: PMC8172772, DOI: 10.3389/fmed.2021.675225.Peer-Reviewed Original ResearchMiddle ear fluidNasopharyngeal swabsMEF samplesOtitis mediaAcute otitis media casesEpidemiological cross-sectional studyPCV7-vaccinated childrenRoutine pneumococcal vaccinationChildren 2 monthsNon-vaccinated childrenOtitis media casesCross-sectional studyNPS samplesOverall case numbersAOM patientsMEF isolatesPCV13 serotypesPCV7 serotypesPneumococcal vaccinationVaccination statusVaccine typesSerotype distributionBacterial etiologyDisease burdenEar fluid