2022
Consideration of sex and gender differences in addiction medication response
McKee SA, McRae-Clark AL. Consideration of sex and gender differences in addiction medication response. Biology Of Sex Differences 2022, 13: 34. PMID: 35761351, PMCID: PMC9235243, DOI: 10.1186/s13293-022-00441-3.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleNicotineSex FactorsSubstance-Related DisordersSurveys and QuestionnairesUnited StatesConceptsSubstance use disordersMedication developmentUse disordersMedication development researchPreventable health conditionsClinical care guidelinesPublic health burdenNational InstituteSex-stratified dataGender differencesCurrent narrative reviewDrugs of abuseMedication trialsSignificant morbidityCare guidelinesMedication responseHealth burdenAbused substancesAlcohol abuseConsideration of sexNarrative reviewIncorporation of sexDrug abuseHealth conditionsSubstance use
2021
Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders
Peltier MR, Verplaetse TL, Mineur YS, Gueorguieva R, Petrakis I, Cosgrove KP, Picciotto MR, McKee SA. Sex differences in progestogen- and androgen-derived neurosteroids in vulnerability to alcohol and stress-related disorders. Neuropharmacology 2021, 187: 108499. PMID: 33600842, PMCID: PMC7992136, DOI: 10.1016/j.neuropharm.2021.108499.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsStress-related disordersAlcohol useMajor depressive disorderAlcohol-related disordersAlcohol use disorderPosttraumatic stress disorderStress regulation systemComplex comorbiditiesDepressive disorderProblematic alcohol useUse disordersAlcohol misuseTherapeutic potentialTrauma exposureSubstance abuseStress disorderAnxiety disordersDisordersExposure resultsProgestogensNeurosteroidsNegative affectWomenComorbiditiesMale counterparts
2020
Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States
Ellis JD, Pittman BP, McKee SA. Co-occurring opioid and sedative use disorder: Gender differences in use patterns and psychiatric co-morbidities in the United States. Journal Of Substance Use And Addiction Treatment 2020, 114: 108012. PMID: 32527509, PMCID: PMC7292885, DOI: 10.1016/j.jsat.2020.108012.Peer-Reviewed Original ResearchConceptsSedative use disorderOpioid use disorderUse disordersCo-occurring opioid use disorderMeeting criteriaPsychiatric conditionsCurrent opioid use disorderCo-occurring opioidPersonality disorderRisk of overdoseLogistic regression analysisCo-occurring symptomsImplementation of treatmentPosttraumatic stress disorderSchizotypal personality disorderAntisocial personality disorderNon-medical useBaseline characteristicsDepressive disorderGender-stratified logistic regression analysesPrescription monitoringOwn prescriptionsOpioidsStress disorderNESARC-IIIAssociations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Verplaetse TL, Peltier MR, Roberts W, Moore KE, Pittman BP, McKee SA. Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study. Nicotine & Tobacco Research 2020, 22: 1316-1321. PMID: 32152625, PMCID: PMC7364844, DOI: 10.1093/ntr/ntaa022.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioFaster nicotine metabolismHigher nicotine metabolite ratioE-cigarette useCigarette smoking statusSlower nicotine metabolismNicotine metabolismE-cigarettesSmoking statusCigarette smokingMetabolite ratiosE-cigarette use statusPopulation-based studyLongitudinal cohort studyWave 1Cigarette smoking behaviorCohort studyClinical trialsTobacco usePATH studyHealth StudySmoking behaviorEarly interventionUS populationCombustible cigarettes
2019
Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine
Lee AM, Calarco CA, McKee SA, Mineur YS, Picciotto MR. Variability in nicotine conditioned place preference and stress‐induced reinstatement in mice: Effects of sex, initial chamber preference, and guanfacine. Genes Brain & Behavior 2019, 19: e12601. PMID: 31364813, PMCID: PMC8045136, DOI: 10.1111/gbb.12601.Peer-Reviewed Original ResearchConceptsStress-induced reinstatementEffects of guanfacinePlace preferenceFemale miceInfralimbic cortexArc immunoreactivityΑ2-adrenergic receptor agonistAnterior insulaNeurobiological mechanismsLateral central amygdalaNovel treatment optionsChamber preferencePlace preference acquisitionSex-dependent changesStress-induced relapseDose-response patternNucleus accumbens coreNicotine-dependent behaviorsSmoking occursTreatment optionsNicotine rewardReceptor agonistCentral amygdalaNeuronal activationPreclinical studies
2018
Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study
Verplaetse TL, Moore KE, Pittman BP, Roberts W, Oberleitner LM, Peltier M, Hacker R, Cosgrove KP, McKee SA. Intersection of E-Cigarette Use and Gender on Transitions in Cigarette Smoking Status: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health Study. Nicotine & Tobacco Research 2018, 21: 1423-1428. PMID: 30239953, PMCID: PMC6751514, DOI: 10.1093/ntr/nty187.Peer-Reviewed Original ResearchConceptsE-cigarette useE-cigarette usersCigarette smoking statusE-cigarettesSmoking statusSmoking cessationCigarette smokersSmoking relapseGreater riskDaily e-cigarette usersWave 1Stratified analysisHigher oddsHealth StudyPotential riskSmokingRelapseDrug AdministrationElectronic cigarettesSmokersPopulation AssessmentPotential aidMenWomenRiskFemale Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease
Han MK, Arteaga-Solis E, Blenis J, Bourjeily G, Clegg DJ, DeMeo D, Duffy J, Gaston B, Heller NM, Hemnes A, Henske EP, Jain R, Lahm T, Lancaster LH, Lee J, Legato MJ, McKee S, Mehra R, Morris A, Prakash YS, Stampfli MR, Gopal-Srivastava R, Laposky AD, Punturieri A, Reineck L, Tigno X, Clayton J. Female Sex and Gender in Lung/Sleep Health and Disease. Increased Understanding of Basic Biological, Pathophysiological, and Behavioral Mechanisms Leading to Better Health for Female Patients with Lung Disease. American Journal Of Respiratory And Critical Care Medicine 2018, 198: 850-858. PMID: 29746147, PMCID: PMC6173069, DOI: 10.1164/rccm.201801-0168ws.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthmaBehaviorComprehensionDisease ManagementEducationFemaleHumansLung DiseasesMiddle AgedNational Heart, Lung, and Blood Institute (U.S.)Pulmonary Disease, Chronic ObstructiveRisk AssessmentSeverity of Illness IndexSex FactorsSleep Apnea SyndromesSleep Wake DisordersUnited StatesWomen's HealthConceptsFemale sexFemale patientsLung diseaseSleep healthChronic obstructive pulmonary diseaseCase of lymphangioleiomyomatosisObstructive pulmonary diseaseSleep-disordered breathingBetter health outcomesNonneoplastic lung diseasesSex-based differencesCardiac morbidityPulmonary diseaseWomen's healthHealth outcomesLung developmentClinical implicationsPresentation differsDiseasePersonalized therapyGood healthWomenNIH OfficePatientsSleep biologyChild Maltreatment and Physical Victimization: Does Heavy Drinking Mediate the Relationship?
Smith KZ, Smith PH, Oberleitner LM, Grekin ER, McKee SA. Child Maltreatment and Physical Victimization: Does Heavy Drinking Mediate the Relationship? Child Maltreatment 2018, 23: 234-243. PMID: 29347837, DOI: 10.1177/1077559517751669.Peer-Reviewed Original Research
2017
Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey
Smith PH, Zhang J, Weinberger AH, Mazure CM, McKee SA. Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey. Drug And Alcohol Dependence 2017, 178: 485-491. PMID: 28715776, PMCID: PMC6779031, DOI: 10.1016/j.drugalcdep.2017.05.046.Peer-Reviewed Original ResearchConceptsTransdermal nicotine patchUnassisted quit attemptsClinical trial dataTobacco Use SupplementQuit attemptsTrial dataClinical trial findingsReal-world effectivenessSample of smokersGender differencesRelevant gender differencesCessation optionsCessation medicationsCessation pharmacotherapyNicotine patchMedication interactionsSmoking cessationPotential confoundersTrial findingsVareniclineComparative effectivenessPropensity scoreCross-sectional dataWomenMedicationsTime Trends in Smoking Onset by Sex and Race/Ethnicity Among Adolescents and Young Adults: Findings From the 2006–2013 National Survey on Drug Use and Health
Thompson AB, Mowery PD, Tebes JK, McKee SA. Time Trends in Smoking Onset by Sex and Race/Ethnicity Among Adolescents and Young Adults: Findings From the 2006–2013 National Survey on Drug Use and Health. Nicotine & Tobacco Research 2017, 20: 312-320. PMID: 28339616, PMCID: PMC5896447, DOI: 10.1093/ntr/ntx010.Peer-Reviewed Original ResearchConceptsSmoking onsetYoung adult malesYoung adultsDrug useLog-binomial regression modelsAnnual declineTobacco-related health disparitiesTime trendsRate of onsetNational surveyTobacco control policiesNumber of adolescentsRace/ethnicityYoung adult femalesRegression modelsAdult malesNew smokersAdult smokingYoung adult yearsEthnic groupsHealth disparitiesGreater riskMore effective strategiesAdultsAdolescents
2016
Sex/gender differences in smoking cessation: A review
Smith PH, Bessette AJ, Weinberger AH, Sheffer CE, McKee SA. Sex/gender differences in smoking cessation: A review. Preventive Medicine 2016, 92: 135-140. PMID: 27471021, PMCID: PMC5085924, DOI: 10.1016/j.ypmed.2016.07.013.Peer-Reviewed Original ResearchConceptsProspective observational studyObservational studyCross-sectional investigationSex/gender differencesSmoking cessationEffectiveness trialCommunity-based interventionsLong-term abstinenceGender differencesSmoker prevalenceEfficacy trialsOutcome assessmentTreatment studiesEpidemiological investigationsMeet criteriaStudy sampleTrialsCessationWomenRelapseSmokingBio-psychoMenQualitative reviewReviewInvestigating Veterans’ Pre-, Peri-, and Post-Deployment Experiences as Potential Risk Factors for Problem Gambling
Whiting SW, Potenza MN, Park CL, McKee SA, Mazure CM, Hoff RA. Investigating Veterans’ Pre-, Peri-, and Post-Deployment Experiences as Potential Risk Factors for Problem Gambling. Journal Of Behavioral Addictions 2016, 5: 213-220. PMID: 27156377, PMCID: PMC5387772, DOI: 10.1556/2006.5.2016.027.Peer-Reviewed Original ResearchDepression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study
Cooper J, Borland R, McKee SA, Yong HH, Dugué PA. Depression motivates quit attempts but predicts relapse: differential findings for gender from the International Tobacco Control Study. Addiction 2016, 111: 1438-1447. PMID: 26888199, PMCID: PMC4940212, DOI: 10.1111/add.13290.Peer-Reviewed Original ResearchConceptsQuit attemptsCessation supportTobacco control studiesDepressive symptomsControl studyInternational Tobacco Control studyQuasi-experimental cohort studyMore quit attemptsMixed-effects logistic regressionLow positive affectNon-depressed counterpartsShort-term abstinenceProspective cohortCohort studyTobacco smokersDepression IndexCurrent depressionSmokersLogistic regressionFirst monthAbstinenceDepressionTelephone surveyDifferential findingsSymptomsPast year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters
Smith KZ, Smith PH, Cercone SA, McKee SA, Homish GG. Past year non-medical opioid use and abuse and PTSD diagnosis: Interactions with sex and associations with symptom clusters. Addictive Behaviors 2016, 58: 167-174. PMID: 26946448, PMCID: PMC4808454, DOI: 10.1016/j.addbeh.2016.02.019.Peer-Reviewed Original ResearchConceptsOpioid use disorder diagnosisNon-medical opioid usePosttraumatic stress disorderHigher oddsSymptom clustersPTSD diagnosisDisorder diagnosisOpioid useAvoidance symptom clustersAverage monthly frequencyNon-institutionalized adultsNational Epidemiologic SurveyIndividual symptom clustersHigh rateSex differencesSpecific symptom clustersImportant sex differencesPTSD symptom clustersReactivity clustersAdjusted modelGeneral U.S.Epidemiologic SurveyRelated conditionsStress disorderDiagnosis
2015
Sex Differences in Varenicline Efficacy for Smoking Cessation: A Meta-Analysis
McKee SA, Smith PH, Kaufman M, Mazure CM, Weinberger AH. Sex Differences in Varenicline Efficacy for Smoking Cessation: A Meta-Analysis. Nicotine & Tobacco Research 2015, 18: 1002-1011. PMID: 26446070, PMCID: PMC5942618, DOI: 10.1093/ntr/ntv207.Peer-Reviewed Original ResearchConceptsSmoking cessation medicationsCessation medicationsSmoking cessationDouble-blind placebo-controlled trialEfficacy of vareniclinePlacebo-controlled trialShort-term outcomesClinical trial dataSex differencesSimilar ratesWeek 52Week 24Women smokersNicotine replacementWeek 12Outcome endpointsTherapeutic responseClinical trialsContinuous abstinenceVarenicline's efficacyVareniclinePlacebo outcomesEqual efficacySex disparitiesEffective FDAImpact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men
Oberleitner LM, Smith PH, Weinberger AH, Mazure CM, McKee SA. Impact of Exposure to Childhood Maltreatment on Transitions to Alcohol Dependence in Women and Men. Child Maltreatment 2015, 20: 301-308. PMID: 26130105, PMCID: PMC4868049, DOI: 10.1177/1077559515591270.Peer-Reviewed Original ResearchConceptsAlcohol useChildhood maltreatmentAlcohol dependenceFourth Edition alcohol dependencePoisson regression analysisNational Epidemiologic SurveyNegative alcohol-related outcomesProblematic alcohol useImpact of exposureEpidemiologic SurveyEarly interventionAlcohol-related outcomesMental disordersBehavioral treatmentRelated conditionsPrevention effortsStatistical ManualOutcome variablesAlcohol initiationWomenRegression analysisAgeMenFirst useMaltreatment
2014
Gender differences in the impact of stressful life events on changes in body mass index
Udo T, Grilo CM, McKee SA. Gender differences in the impact of stressful life events on changes in body mass index. Preventive Medicine 2014, 69: 49-53. PMID: 25204986, PMCID: PMC4312235, DOI: 10.1016/j.ypmed.2014.08.036.Peer-Reviewed Original ResearchConceptsBody mass indexStressful life eventsWave 2 interviewsWeight gainMass indexLife eventsNational Epidemiologic SurveyGreater weight gainWave 1Epidemiologic SurveyRelated conditionsFemale-specific effectWomenWave 2 surveyPositive associationEffects of stressGreater increaseDeath of familyRepresentative sampleMenGender differencesPhysiological mechanisms
2013
Sex differences in biopsychosocial correlates of binge eating disorder: a study of treatment-seeking obese adults in primary care setting
Udo T, McKee SA, White MA, Masheb RM, Barnes RD, Grilo CM. Sex differences in biopsychosocial correlates of binge eating disorder: a study of treatment-seeking obese adults in primary care setting. General Hospital Psychiatry 2013, 35: 587-591. PMID: 23969142, PMCID: PMC3845204, DOI: 10.1016/j.genhosppsych.2013.07.010.Peer-Reviewed Original ResearchConceptsPrimary care settingBiopsychosocial correlatesTreatment-seeking obese patientsPsychosocial factorsSex differencesCare settingsObese menObese adultsClinical studiesFrequent strenuous exercisePsychological impairmentDisorder featuresOnset of overweightCommunity-based studySignificant sex differencesDevelopmental historyTreatment studiesObese patientsBlood pressureMetabolic syndromeBingePrimary careStrenuous exerciseActive screeningGlucose levels
2012
Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990–2010
Weinberger AH, Mazure CM, Morlett A, McKee SA. Two Decades of Smoking Cessation Treatment Research on Smokers with Depression: 1990–2010. Nicotine & Tobacco Research 2012, 15: 1014-1031. PMID: 23100459, PMCID: PMC3693502, DOI: 10.1093/ntr/nts213.Peer-Reviewed Original ResearchConceptsRelationship of depressionSmoking cessation outcomesCessation outcomesSmoking cessationTreatment outcomesCurrent major depressive disorderMajor depressive disorderCurrent depression symptomsClinical trialsDepressive disorderMinor depressionMajor depressionInclusion criteriaMEDLINE searchPast diagnosisTreatment approachesDepression symptomsHealth-related risksMajority of studiesPotential articlesDepressionRacial differencesOutcomesCessationSmokersSmoke-free policies in drinking venues predict transitions in alcohol use disorders in a longitudinal U.S. sample
Young-Wolff KC, Hyland AJ, Desai R, Sindelar J, Pilver CE, McKee SA. Smoke-free policies in drinking venues predict transitions in alcohol use disorders in a longitudinal U.S. sample. Drug And Alcohol Dependence 2012, 128: 214-221. PMID: 22999418, PMCID: PMC4052952, DOI: 10.1016/j.drugalcdep.2012.08.028.Peer-Reviewed Original ResearchConceptsAlcohol use disorderSmoke-free legislationSmoke-free policiesAUD remissionUse disordersLikelihood of AUDWave IIndoor public venuesLongitudinal U.S. sampleTobacco-related diseasesYounger age groupsNational Epidemiological SurveySmoke-free barsPublic health benefitsAUD onsetHigh comorbidityProtective effectCurrent drinkersTobacco useEpidemiological surveyAge groupsLogistic regressionRelated conditionsHeavy drinkingLower likelihood