2018
A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers
Roberts W, Verplaetse TL, Moore KE, Oberleitner LM, McKee SA. A preliminary investigation into the effects of doxazosin on cognitive functioning in tobacco‐deprived and ‐satiated smokers. Human Psychopharmacology Clinical And Experimental 2018, 33: e2660. PMID: 29878501, PMCID: PMC5995328, DOI: 10.1002/hup.2660.Peer-Reviewed Original ResearchConceptsContinuous performance taskInhibitory controlCognitive functioningPerformance taskTobacco withdrawalEffects of doxazosinSustained attentionCognitive performanceWithdrawal symptomsCognitive AssessmentSmoking outcomesMost measuresSelf-reported withdrawal symptomsReaction timeTaskParticipantsFunctioningPredrug levelsΑ1 antagonistTitration periodGreater improvementDoxazosinSmokingSymptomsPreliminary investigationEffects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes
Roberts W, McKee SA. Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes. Experimental And Clinical Psychopharmacology 2018, 26: 49-57. PMID: 29389170, PMCID: PMC5797996, DOI: 10.1037/pha0000161.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive functioningCognitive assessment batteryContinuous performance taskAdult heavy drinkersSignificant indirect effectUse disordersReaction timeEffects of vareniclinePerformance taskHeavy drinkersCognitive outcomesAssessment BatteryHuman laboratory experimentsCognitive functionMediation analysisDrinking outcomesMemoryLess drinkingAlcohol useDrinking behaviorIndirect effectsLaboratory sessionsDrinking taskVarenicline dose
2012
Mood and smoking behavior: The role of expectancy accessibility and gender
Weinberger AH, McKee SA. Mood and smoking behavior: The role of expectancy accessibility and gender. Addictive Behaviors 2012, 37: 1349-1352. PMID: 22958868, PMCID: PMC3440619, DOI: 10.1016/j.addbeh.2012.07.010.Peer-Reviewed Original ResearchConceptsMood inductionExpectancy accessibilitySmoking behaviorSmoking expectanciesNegative reinforcement smoking expectanciesNegative mood inductionPositive mood inductionNegative reinforcement expectanciesMusical mood inductionRole of expectancySmoking-related beliefsSingle laboratory sessionInter-puff intervalLonger puff durationExpectancy endorsementGender-specific mechanismsNegative affectReinforcement expectanciesGender-specific factorsFemale smokersMore cigarettesSmoking topographyAdult smokersTreatment developmentRelationship of genderEffects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers
Ashare RL, McKee SA. Effects of Varenicline and Bupropion on Cognitive Processes Among Nicotine-Deprived Smokers. Experimental And Clinical Psychopharmacology 2012, 20: 63-70. PMID: 21942262, PMCID: PMC3640636, DOI: 10.1037/a0025594.Peer-Reviewed Original ResearchConceptsNicotine deprivationCognitive processesMeasures of attentionNicotine-deprived smokersMeasures of cravingEffects of vareniclineNegative affectOvernight abstinenceCurrent data highlightMemoryReduced accuracyDaily smokersCurrent sampleDifficulty concentratingLaboratory sessionsEffects of bupropionFuture researchReaction timeSex differencesRecent researchAbstinence ratesDeficitsNew pharmacological treatmentsParticipantsSmoking cessation
2009
Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study
McKee SA, Weinberger AH, Harrison EL, Coppola S, George TP. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study. Schizophrenia Research 2009, 115: 317-324. PMID: 19700263, PMCID: PMC2784178, DOI: 10.1016/j.schres.2009.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior, AddictiveDouble-Blind MethodFemaleHumansMaleMecamylamineMiddle AgedNeuropsychological TestsNicotinic AntagonistsReaction TimeSchizophreniaSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderYoung AdultConceptsAd lib smoking behaviorNicotine levelsSmoking behaviorControl smokersSmoking topographyNicotinic receptor antagonist mecamylamineNicotinic acetylcholine receptor antagonistHealthy control smokersHigh-affinity nAChRsIntensity of smokingAd lib smokingEffects of mecamylamineNumber of cigarettesPlacebo-controlled designAcetylcholine receptor antagonistNicotine exposureAntagonist mecamylamineCompensatory smokingReceptor antagonistSmoking intensityMecamylamineSmokersSmokingSchizophreniaPreliminary studyNicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention
Harrison EL, Coppola S, McKee SA. Nicotine Deprivation and Trait Impulsivity Affect Smokers' Performance on Cognitive Tasks of Inhibition and Attention. Experimental And Clinical Psychopharmacology 2009, 17: 91-98. PMID: 19331485, PMCID: PMC2863308, DOI: 10.1037/a0015657.Peer-Reviewed Original ResearchConceptsCognitive processingNicotine deprivationImpulsive smokersTrait impulsivityGo/No-Go taskBarratt Impulsiveness ScaleCognitive tasksInhibitory controlPerformance decrementsImpulsiveness ScaleTask IISubjects designImpulsivityGreater impairmentDaily smokersReaction timeDeprivation conditionsMixed model regression analysisTaskProcessingRelapse riskImpairmentSignificant deprivationImpulsivenessDeprivation