2022
Consideration of sex and gender differences in addiction medication response
McKee SA, McRae-Clark AL. Consideration of sex and gender differences in addiction medication response. Biology Of Sex Differences 2022, 13: 34. PMID: 35761351, PMCID: PMC9235243, DOI: 10.1186/s13293-022-00441-3.Peer-Reviewed Original ResearchMeSH KeywordsFemaleHumansMaleNicotineSex FactorsSubstance-Related DisordersSurveys and QuestionnairesUnited StatesConceptsSubstance use disordersMedication developmentUse disordersMedication development researchPreventable health conditionsClinical care guidelinesPublic health burdenNational InstituteSex-stratified dataGender differencesCurrent narrative reviewDrugs of abuseMedication trialsSignificant morbidityCare guidelinesMedication responseHealth burdenAbused substancesAlcohol abuseConsideration of sexNarrative reviewIncorporation of sexDrug abuseHealth conditionsSubstance use
2020
Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study
Verplaetse TL, Peltier MR, Roberts W, Moore KE, Pittman BP, McKee SA. Associations Between Nicotine Metabolite Ratio and Gender With Transitions in Cigarette Smoking Status and E-Cigarette Use: Findings Across Waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study. Nicotine & Tobacco Research 2020, 22: 1316-1321. PMID: 32152625, PMCID: PMC7364844, DOI: 10.1093/ntr/ntaa022.Peer-Reviewed Original ResearchConceptsNicotine metabolite ratioFaster nicotine metabolismHigher nicotine metabolite ratioE-cigarette useCigarette smoking statusSlower nicotine metabolismNicotine metabolismE-cigarettesSmoking statusCigarette smokingMetabolite ratiosE-cigarette use statusPopulation-based studyLongitudinal cohort studyWave 1Cigarette smoking behaviorCohort studyClinical trialsTobacco usePATH studyHealth StudySmoking behaviorEarly interventionUS populationCombustible cigarettes
2017
Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey
Smith PH, Zhang J, Weinberger AH, Mazure CM, McKee SA. Gender differences in the real-world effectiveness of smoking cessation medications: Findings from the 2010–2011 Tobacco Use Supplement to the Current Population Survey. Drug And Alcohol Dependence 2017, 178: 485-491. PMID: 28715776, PMCID: PMC6779031, DOI: 10.1016/j.drugalcdep.2017.05.046.Peer-Reviewed Original ResearchConceptsTransdermal nicotine patchUnassisted quit attemptsClinical trial dataTobacco Use SupplementQuit attemptsTrial dataClinical trial findingsReal-world effectivenessSample of smokersGender differencesRelevant gender differencesCessation optionsCessation medicationsCessation pharmacotherapyNicotine patchMedication interactionsSmoking cessationPotential confoundersTrial findingsVareniclineComparative effectivenessPropensity scoreCross-sectional dataWomenMedicationsTime Trends in Smoking Onset by Sex and Race/Ethnicity Among Adolescents and Young Adults: Findings From the 2006–2013 National Survey on Drug Use and Health
Thompson AB, Mowery PD, Tebes JK, McKee SA. Time Trends in Smoking Onset by Sex and Race/Ethnicity Among Adolescents and Young Adults: Findings From the 2006–2013 National Survey on Drug Use and Health. Nicotine & Tobacco Research 2017, 20: 312-320. PMID: 28339616, PMCID: PMC5896447, DOI: 10.1093/ntr/ntx010.Peer-Reviewed Original ResearchConceptsSmoking onsetYoung adult malesYoung adultsDrug useLog-binomial regression modelsAnnual declineTobacco-related health disparitiesTime trendsRate of onsetNational surveyTobacco control policiesNumber of adolescentsRace/ethnicityYoung adult femalesRegression modelsAdult malesNew smokersAdult smokingYoung adult yearsEthnic groupsHealth disparitiesGreater riskMore effective strategiesAdultsAdolescents
2014
What is the evidence for hardening in the cigarette smoking population? Trends in nicotine dependence in the U.S., 2002–2012
Smith PH, Rose JS, Mazure CM, Giovino GA, McKee SA. What is the evidence for hardening in the cigarette smoking population? Trends in nicotine dependence in the U.S., 2002–2012. Drug And Alcohol Dependence 2014, 142: 333-340. PMID: 25064023, PMCID: PMC4158455, DOI: 10.1016/j.drugalcdep.2014.07.003.Peer-Reviewed Original ResearchConceptsLow-income smokersNicotine dependenceCigarette smoking populationMiddle-aged smokersDependence severitySerious psychological distressNicotine dependence severitySocio-demographic factorsCurrent smokersCigarette smokingSmoking populationSmokersTobacco consumptionGreater severityDrug useSmokingStudy periodPsychological distressSeverityNational surveyWomen
2010
Differences in smoking expectancies in smokers with and without a history of major depression
Weinberger AH, George TP, McKee SA. Differences in smoking expectancies in smokers with and without a history of major depression. Addictive Behaviors 2010, 36: 434-437. PMID: 21239119, PMCID: PMC3052745, DOI: 10.1016/j.addbeh.2010.12.024.Peer-Reviewed Original ResearchConceptsHistory of depressionMajor depressive disorderSmoking cessationClinical trialsSmoking expectanciesAdult cigarette smokersInteraction of depressionSmoking cessation behaviorsLower quit ratesMDD- smokersCigarette smokersDepressive disorderAdult smokersCognitive-behavioral treatmentMajor depressionQuit ratesCessation behaviorsSmokersSelegiline hydrochlorideSmokingSecondary aimEvidence high ratesDepressionSmoking beliefsHigh rateChanges in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessation
Weinberger AH, McKee SA, George TP. Changes in smoking expectancies in abstinent, reducing, and non-abstinent participants during a pharmacological trial for smoking cessation. Nicotine & Tobacco Research 2010, 12: 937-943. PMID: 20644207, PMCID: PMC2928936, DOI: 10.1093/ntr/ntq120.Peer-Reviewed Original ResearchConceptsNegative affect reductionNegative physical feelingsWeight control beliefsNon-abstinent participantsSmoking status interactionSmoking expectanciesNegative affectSmoking cessation treatmentControl beliefsSmoking beliefsSmoking cessation trialPoint prevalence abstinenceSocial facilitationBaseline expectanciesEnd of treatmentSocial interactionSmoking treatmentCessation outcomesQuit attemptsAbstinence outcomesCessation treatmentPhysical feelingsGender differencesCessation trialBeliefs
2009
Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study
McKee SA, Weinberger AH, Harrison EL, Coppola S, George TP. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study. Schizophrenia Research 2009, 115: 317-324. PMID: 19700263, PMCID: PMC2784178, DOI: 10.1016/j.schres.2009.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior, AddictiveDouble-Blind MethodFemaleHumansMaleMecamylamineMiddle AgedNeuropsychological TestsNicotinic AntagonistsReaction TimeSchizophreniaSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderYoung AdultConceptsAd lib smoking behaviorNicotine levelsSmoking behaviorControl smokersSmoking topographyNicotinic receptor antagonist mecamylamineNicotinic acetylcholine receptor antagonistHealthy control smokersHigh-affinity nAChRsIntensity of smokingAd lib smokingEffects of mecamylamineNumber of cigarettesPlacebo-controlled designAcetylcholine receptor antagonistNicotine exposureAntagonist mecamylamineCompensatory smokingReceptor antagonistSmoking intensityMecamylamineSmokersSmokingSchizophreniaPreliminary studyLongitudinal evaluation of smoke-free Scotland on pub and home drinking behavior: Findings from the International Tobacco Control Policy Evaluation Project
McKee SA, Higbee C, O'Malley S, Hassan L, Borland R, Cummings KM, Hastings G, Fong GT, Hyland A. Longitudinal evaluation of smoke-free Scotland on pub and home drinking behavior: Findings from the International Tobacco Control Policy Evaluation Project. Nicotine & Tobacco Research 2009, 11: 619-626. PMID: 19351787, PMCID: PMC2688599, DOI: 10.1093/ntr/ntp020.Peer-Reviewed Original ResearchConceptsSmoke-free policiesPolicy implementationUnited KingdomComprehensive smoke-free policiesInternational Tobacco Control Policy Evaluation ProjectPublic venuesHeavy drinkersDrinking behaviorAdditional public health benefitsAlcohol-related health problemsIndoor public venuesPolicySmoke-free legislationPublic health benefitsAdult smokersMean changeModerate drinkersSmokersHealth problemsLongitudinal evaluationGreater riskPubsScotlandLegislationStudy period
2008
Correspondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings
Toll BA, Cooney JL, McKee SA, O'Malley SS, Cooney NL. Correspondence of Interactive Voice Response (IVR) Reports of Nicotine Withdrawal, Craving, and Negative Mood with Questionnaire Ratings. Nicotine & Tobacco Research 2008, 10: 1057-1064. PMID: 18584469, PMCID: PMC2791461, DOI: 10.1080/14622200802097498.Peer-Reviewed Original ResearchConceptsNicotine withdrawalDepressive symptomsSmoking cessation trialCessation trialDaily smokersInteractive voice response systemVoice response systemDaily assessmentCravingWeeksNegative moodWithdrawalSymptomsPaper questionnaireQuestionnaire ratingsReportFuture studiesQuestionnaireIVR systemMoodDaysSample sizeDaily reportsSmokersSmoking
2007
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
McKee SA, O’Malley S, Shi J, Mase T, Krishnan-Sarin S. Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology 2007, 196: 189-200. PMID: 17912500, PMCID: PMC2862181, DOI: 10.1007/s00213-007-0952-3.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdultAlcohol DrinkingBlood PressureChromatography, High Pressure LiquidDose-Response Relationship, DrugDouble-Blind MethodDrinking BehaviorFemaleHeart RateHumansMaleMiddle AgedMonitoring, PhysiologicNicotineOscillometrySelf AdministrationSelf-AssessmentSkin TemperatureSmoking PreventionSpectrophotometry, UltravioletSurveys and QuestionnairesTime FactorsConceptsTransdermal nicotine replacementNicotine replacementSelf-administration periodPriming drinkHeavy drinkersPatch applicationNicotine deprivationAlcohol responsesNicotine patch conditionPlacebo patch conditionDouble-blind studySystolic blood pressureHeavy drinking smokersPatch conditionsAlcohol drinking behaviorTransdermal patch applicationDrinking behaviorInitiation of drinkingBlood pressurePlacebo patchAdditional drinkDaily smokersTobacco cravingTobacco useHeart rateGender differences in the comorbidity of smoking behavior and major depression
Husky MM, Mazure CM, Paliwal P, McKee SA. Gender differences in the comorbidity of smoking behavior and major depression. Drug And Alcohol Dependence 2007, 93: 176-179. PMID: 17850991, PMCID: PMC2247435, DOI: 10.1016/j.drugalcdep.2007.07.015.Peer-Reviewed Original ResearchConceptsMajor depressionPrior smokingSmoking behaviorPast depressionDSM-IV major depressionPrior major depressionLifetime major depressionNational Epidemiologic SurveySmoking statusCessation interventionsDaily smokingOdds ratioHigh riskNicotine dependenceSmoking relapseEpidemiologic SurveySmokingLogistic regressionRelated conditionsDepressionWomenAssociationGender differencesFunction of genderComorbiditiesFactor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit.
Toll BA, McKee SA, Martin DJ, Jatlow P, O'Malley SS. Factor structure and validity of the Medication Adherence Questionnaire (MAQ) with cigarette smokers trying to quit. Nicotine & Tobacco Research 2007, 9: 597-605. PMID: 17454716, PMCID: PMC2527736, DOI: 10.1080/14622200701239662.Peer-Reviewed Original ResearchConceptsMedication Adherence QuestionnaireCigarette smokersNicotine patchAdherence QuestionnaireMedication adherenceNicotine patch useSmoking cessation outcomesPill-taking behaviorSample of smokersDrug plasma levelsBrief screening toolNonadherence factorsMedication useUnintentional nonadherencePlasma levelsCessation outcomesClinical trialsTreatment outcomesDrug levelsPredictive validitySmokersMAQ scoresNonadherenceScreening toolFactor 1Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study
Toll BA, Schepis TS, O’Malley S, McKee SA, Krishnan-Sarin S. Subjective reactivity to the first cigarette of the day as a predictor of smoking relapse: A preliminary study. Drug And Alcohol Dependence 2007, 89: 302-305. PMID: 17320313, PMCID: PMC2475673, DOI: 10.1016/j.drugalcdep.2007.01.011.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAffectAgedAntidepressive Agents, Second-GenerationBehavior TherapyBupropionCircadian RhythmDelayed-Action PreparationsFemaleHumansMaleMiddle AgedMotivationNicotineOutcome Assessment, Health CarePrognosisSecondary PreventionSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderConceptsFirst cigaretteSmoking relapseEnd of treatmentCessation treatment outcomeInitial cigaretteWithdrawal symptomsClinical trialsQuit dayTreatment outcomesNovel predictorRelapseCigarettesPreliminary studyTime pointsGreater decreaseCravingSubjective responsesSubjective reactivityDaysFuture studiesSignificant changesWithdrawalPredictorsResponseBupropion
2006
A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation
O’Malley S, Cooney JL, Krishnan-Sarin S, Dubin JA, McKee SA, Cooney NL, Blakeslee A, Meandzija B, Romano-Dahlgard D, Wu R, Makuch R, Jatlow P. A Controlled Trial of Naltrexone Augmentation of Nicotine Replacement Therapy for Smoking Cessation. JAMA Internal Medicine 2006, 166: 667-674. PMID: 16567607, DOI: 10.1001/archinte.166.6.667.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdministration, OralAmbulatory CareDose-Response Relationship, DrugDouble-Blind MethodDrug Therapy, CombinationFemaleHumansLinear ModelsMaleMiddle AgedNaltrexoneNarcotic AntagonistsNicotineNicotinic AgonistsSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTreatment OutcomeWeight GainConceptsNicotine patch therapyNicotine patchPatch therapyDouble-blind placebo-controlled trialHigher continuous abstinence ratesLow-dose naltrexone therapyNaltrexone hydrochlorideWeight gainTreatment completersOral naltrexone hydrochlorideOutpatient research centerWeight-concerned smokersContinuous abstinence ratesPlacebo-controlled trialPrimary end pointSecond-line treatmentNicotine replacement therapyNaltrexone augmentationNaltrexone therapyPlacebo groupQuit dateTreat analysisAbstinence ratesReplacement therapySmoking cessation
2005
Investigating the factor structure of the Questionnaire on Smoking Urges-Brief (QSU-Brief)
Toll BA, Katulak NA, McKee SA. Investigating the factor structure of the Questionnaire on Smoking Urges-Brief (QSU-Brief). Addictive Behaviors 2005, 31: 1231-1239. PMID: 16226843, PMCID: PMC2527734, DOI: 10.1016/j.addbeh.2005.09.008.Peer-Reviewed Original ResearchConceptsSmoking Urges-BriefTreatment-seeking populationQSU-BriefSmoking urgesGood internal consistency reliability estimateStudy sampleFive-itemTwo-factor structurePsychometric propertiesPresent studyQuestionnaireInitial exploratory factor analysisInternal consistency reliability estimatesFactor analysisExploratory factor analysisFactor analytic findingsReliable assessmentSmokersScoringConfirmatory factor analysisKnowledge and perceived risk of smoking-related conditions: a survey of cigarette smokers
Oncken C, McKee S, Krishnan-Sarin S, O'Malley S, Mazure CM. Knowledge and perceived risk of smoking-related conditions: a survey of cigarette smokers. Preventive Medicine 2005, 40: 779-784. PMID: 15850879, DOI: 10.1016/j.ypmed.2004.09.024.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsChi-Square DistributionConnecticutCross-Sectional StudiesFemaleFollow-Up StudiesHealth Knowledge, Attitudes, PracticeHumansIncidenceMaleMiddle AgedPredictive Value of TestsProbabilityRisk AssessmentRisk-TakingSex FactorsSmokingSmoking CessationSmoking PreventionSurveys and QuestionnairesSurvival RateTobacco Use DisorderConceptsSmoking-related conditionsMedical conditionsSmoking-related disease riskDisease categoriesPremature deathOral health diseasesSmoking-related cancersSmoking-related illnessesAdult treatment-seeking smokersPersonal health risksQuality of lifeTreatment-seeking smokersCurrent smokersCigarette smokersLung cancerOral diseasesSmokersSmokingDisease riskReproductive risksHealth diseasesCancerRiskHealth risksDiseasePerceived risks and benefits of smoking cessation: Gender-specific predictors of motivation and treatment outcome
McKee SA, O'Malley SS, Salovey P, Krishnan-Sarin S, Mazure CM. Perceived risks and benefits of smoking cessation: Gender-specific predictors of motivation and treatment outcome. Addictive Behaviors 2005, 30: 423-435. PMID: 15718060, DOI: 10.1016/j.addbeh.2004.05.027.Peer-Reviewed Original ResearchConceptsPretreatment motivationTreatment-seeking smokersSelf-report instrumentGood psychometric propertiesSmoking cessationGender-specific predictorsTreatment outcomesSmoking cessation trialLikelihood ratingsBehavioral intentionsPsychometric propertiesMotivationIntervention strategiesCessation trialGender differencesPublic education campaignsPrimary aimStrong associationBeliefsParticipantsRatingsIntentionOutcomesSubsampleEducation campaigns
2004
Revisiting the Factor Structure of the Questionnaire on Smoking Urges
Toll BA, McKee SA, Krishnan-Sarin S, O'Malley SS. Revisiting the Factor Structure of the Questionnaire on Smoking Urges. Psychological Assessment 2004, 16: 391-395. PMID: 15584799, PMCID: PMC2527732, DOI: 10.1037/1040-3590.16.4.391.Peer-Reviewed Original ResearchSurvey of subjective effects of smoking while drinking among college students
McKee SA, Hinson R, Rounsaville D, Petrelli P. Survey of subjective effects of smoking while drinking among college students. Nicotine & Tobacco Research 2004, 6: 111-117. PMID: 14982695, DOI: 10.1080/14622200310001656939.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingFemaleHumansMaleReinforcement, PsychologySmokingStudentsSurveys and QuestionnairesUniversitiesConceptsInfluence of alcoholTobacco useSubjective effectsGreater subjective effectsWeekly alcohol consumptionCollege studentsStronger subjective effectsMean ageFirst-year college studentsSmoking ratesSmoking episodesSmokersAlcohol consumptionConcurrent alcoholSmokingStandard drinksAlcohol useDrinking episodesSubjective reactivityRegular useCollege-age populationPositive reinforcementSignificant percentagePositive experiencesWeeks