2023
The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke
Peltier M, McKee S. The role of sex hormones in targeting stress-induced tobacco craving, stress-reactivity, and smoking with guanfacine among women who smoke. Addiction Neuroscience 2023, 7: 100084. PMID: 37396408, PMCID: PMC10311966, DOI: 10.1016/j.addicn.2023.100084.Peer-Reviewed Original ResearchSex hormonesTobacco cravingMedication effectsMedication trialsSmoking behaviorCortisol responsePlacebo-controlled studySmoking cessation trialAd libitum periodGuanfacine's effectsCessation trialSmoking periodDrug effectsSecondary analysisGuanfacineEstradiolHormoneProgesteroneWomenCravingTrialsSex differencesContext of stressPresent studyPost-stress induction
2019
Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers.
Verplaetse TL, Roberts W, Moore KE, Peltier MR, Oberleitner LM, McKee SA. Pharmacokinetics and Pharmacodynamics of Immediate-Release Versus Extended-Release Guanfacine in Adult Daily Smokers. Journal Of Clinical Psychopharmacology 2019, 39: 124-128. PMID: 30707118, PMCID: PMC6391212, DOI: 10.1097/jcp.0000000000001004.Peer-Reviewed Original ResearchConceptsAdult daily smokersDoses of guanfacineAdverse eventsMedication levelsDaily smokersTobacco cravingTreatment-emergent adverse eventsExtended-release formulationSimilar pharmacokinetic profileAttention deficit hyperactivity disorderDry mouthLast doseMigraine prophylaxisBlood pressureHeroin withdrawalStable dosingDose equivalencyHeart rateER formulationSmoking outcomesGuanfacinePharmacokinetic profileDrug AdministrationVital signsHyperactivity disorder
2018
Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation
Oberleitner LMS, Moore KE, Verplaetse T, Roberts W, McKee SA. Developing a Laboratory Model of Smoking Lapse Targeting Stress and Brief Nicotine Deprivation. Experimental And Clinical Psychopharmacology 2018, 26: 244-250. PMID: 29863382, PMCID: PMC5990030, DOI: 10.1037/pha0000187.Peer-Reviewed Original ResearchConceptsNicotine deprivationAd libitum smokingSmoking lapse behaviorHuman laboratory modelImagery inductionSmoking periodOnly significant differenceDaily smokersTobacco cravingMonetary reinforcementSmokingSeparate daysHuman laboratoryLapse behaviorSignificant differencesMood statesEffects of stressReduced abilityDelay periodNegative mood statesPrimary aimStress imagerySecondary goalCurrent studyNeutral imageryPilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior
Verplaetse TL, Weinberger AH, Ashare RL, Pittman BP, Shi JM, Tetrault JM, Lavery M, McKee SA. Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior. Journal Of Psychopharmacology 2018, 32: 1003-1009. PMID: 29692206, PMCID: PMC6258014, DOI: 10.1177/0269881118767647.Peer-Reviewed Original ResearchConceptsEffects of carvedilolSmoking lapse behaviorAdrenergic antagonistsTobacco cravingSmoking outcomesPhysiologic reactivitySystolic blood pressureNumber of cigarettesNicotine-motivated behaviors× time effectSelf-administration periodEffects of α1Human laboratory modelNicotine-deprived smokersPlacebo groupBlood pressureAdrenergic antagonismMedication conditionClinical indicationsNoradrenergic systemSubsequent smokingHeart rateProperties of drugsSmokingCarvedilol
2017
Effects of varenicline on alcohol cue reactivity in heavy drinkers
Roberts W, Harrison ELR, McKee SA. Effects of varenicline on alcohol cue reactivity in heavy drinkers. Psychopharmacology 2017, 234: 2737-2745. PMID: 28600734, PMCID: PMC5709183, DOI: 10.1007/s00213-017-4667-9.Peer-Reviewed Original ResearchConceptsEffects of vareniclineHuman laboratory studiesAlcohol use disorderAlcohol cue reactivityHeavy drinkersUse disordersPlacebo-controlled human laboratory studyCue exposureAlcohol useCue reactivityUse of vareniclineFront-line treatmentCue-induced alcohol cravingAlcohol cue exposureTitration periodCue-reactivity paradigmMedication groupPharmacological treatmentMedication effectsAdult smokersTobacco cravingVareniclineMethodsAs partLarge seriesAlcohol cravingEffect of doxazosin on stress reactivity and the ability to resist smoking
Verplaetse TL, Weinberger AH, Oberleitner LM, Smith KM, Pittman BP, Shi JM, Tetrault JM, Lavery ME, Picciotto MR, McKee SA. Effect of doxazosin on stress reactivity and the ability to resist smoking. Journal Of Psychopharmacology 2017, 31: 830-840. PMID: 28440105, PMCID: PMC5823502, DOI: 10.1177/0269881117699603.Peer-Reviewed Original ResearchConceptsTobacco cravingCortisol levelsSubsequent ad libitum smokingEffects of doxazosinAd libitum smokingNumber of cigarettesNicotine-motivated behaviorsSmoking lapse behaviorΑ1-adrenergic antagonistNicotine-deprived smokersTitration periodPreclinical findingsSmoking cessationNoradrenergic systemTreatment strategiesDoxazosinSmoking behaviorSmokingHuman laboratoryPhysiologic reactivityPilot studyStress reactivityEffects of stressCigarettesStress imagery
2014
A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten A, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology 2014, 29: 300-311. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.Peer-Reviewed Original ResearchConceptsPlacebo-treated subjectsFunctional magnetic resonance imagingCentral noradrenergic pathwaysPrefrontal cognitive dysfunctionSystolic blood pressureClinical outcome dataAd libitum smokingNovel translational approachStress-induced reinstatementMagnetic resonance imagingNicotine-deprived smokersBlood pressureNoradrenergic pathwaysAgonist guanfacineCognitive dysfunctionTreatment periodTobacco cravingQuit attemptsOutcome dataSmokingComplete abstinenceCortisol levelsTranslational investigationsCigarette useGuanfacine
2010
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison E, Lavery M, Wanzer J. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Journal Of Psychopharmacology 2010, 25: 490-502. PMID: 20817750, PMCID: PMC3637660, DOI: 10.1177/0269881110376694.Peer-Reviewed Original ResearchConceptsSelf-administration sessionsFirst cigaretteTobacco cravingNovel human laboratory modelAdrenal (HPA) axis reactivitySmoking lapse behaviorHuman laboratory modelImpact of stressNegative emotionsTobacco relapseDaily smokersSubsequent smokingImagery inductionAxis reactivitySmokingSubjects designSeparate daysPhysiologic reactivityMonetary reinforcementLapse behaviorTopography systemRelapseGreater satisfactionReduced abilityStress inductionNicotine and food deprivation decrease the ability to resist smoking
Leeman RF, O’Malley S, White MA, McKee SA. Nicotine and food deprivation decrease the ability to resist smoking. Psychopharmacology 2010, 212: 25-32. PMID: 20585761, PMCID: PMC3111597, DOI: 10.1007/s00213-010-1902-z.Peer-Reviewed Original ResearchConceptsSubsequent ad libitum smokingNicotine deprivationAd libitum smokingFood deprivationSmoking lapse behaviorSelf-administration periodEffect of foodSmokers' abilityMore cigarettesFirst cigaretteHuman laboratory paradigmDaily smokersTobacco cravingFood intakeCessation failureSmokingConclusionsThese findingsFood cuesMonetary reinforcementCigarettesNicotineSex differencesDeprivationLaboratory sessionsOutcomes
2007
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
McKee SA, O’Malley S, Shi J, Mase T, Krishnan-Sarin S. Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology 2007, 196: 189-200. PMID: 17912500, PMCID: PMC2862181, DOI: 10.1007/s00213-007-0952-3.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdultAlcohol DrinkingBlood PressureChromatography, High Pressure LiquidDose-Response Relationship, DrugDouble-Blind MethodDrinking BehaviorFemaleHeart RateHumansMaleMiddle AgedMonitoring, PhysiologicNicotineOscillometrySelf AdministrationSelf-AssessmentSkin TemperatureSmoking PreventionSpectrophotometry, UltravioletSurveys and QuestionnairesTime FactorsConceptsTransdermal nicotine replacementNicotine replacementSelf-administration periodPriming drinkHeavy drinkersPatch applicationNicotine deprivationAlcohol responsesNicotine patch conditionPlacebo patch conditionDouble-blind studySystolic blood pressureHeavy drinking smokersPatch conditionsAlcohol drinking behaviorTransdermal patch applicationDrinking behaviorInitiation of drinkingBlood pressurePlacebo patchAdditional drinkDaily smokersTobacco cravingTobacco useHeart rate
2006
Modeling the effect of alcohol on smoking lapse behavior
McKee SA, Krishnan-Sarin S, Shi J, Mase T, O’Malley S. Modeling the effect of alcohol on smoking lapse behavior. Psychopharmacology 2006, 189: 201-210. PMID: 17013640, PMCID: PMC2862311, DOI: 10.1007/s00213-006-0551-8.Peer-Reviewed Original ResearchConceptsFirst cigaretteSelf-administration sessionsNovel human laboratory modelPoor smoking cessation outcomesSmoking cessation outcomesSmoking lapse behaviorHuman laboratory modelEffects of alcoholSecondary outcomesAlcohol drinkersLapse behaviorMore cigarettesNicotine withdrawalCessation outcomesRisk factorsDaily smokersSubsequent smokingTobacco cravingPlacebo beverageTobacco relapseSmoking sessionHeavy social drinkersPriming drinkAlcohol consumptionAlcohol use