2010
Stress decreases the ability to resist smoking and potentiates smoking intensity and reward
McKee SA, Sinha R, Weinberger AH, Sofuoglu M, Harrison E, Lavery M, Wanzer J. Stress decreases the ability to resist smoking and potentiates smoking intensity and reward. Journal Of Psychopharmacology 2010, 25: 490-502. PMID: 20817750, PMCID: PMC3637660, DOI: 10.1177/0269881110376694.Peer-Reviewed Original ResearchConceptsSelf-administration sessionsFirst cigaretteTobacco cravingNovel human laboratory modelAdrenal (HPA) axis reactivitySmoking lapse behaviorHuman laboratory modelImpact of stressNegative emotionsTobacco relapseDaily smokersSubsequent smokingImagery inductionAxis reactivitySmokingSubjects designSeparate daysPhysiologic reactivityMonetary reinforcementLapse behaviorTopography systemRelapseGreater satisfactionReduced abilityStress induction
2008
Developing human laboratory models of smoking lapse behavior for medication screening
McKee SA. Developing human laboratory models of smoking lapse behavior for medication screening. Addiction Biology 2008, 14: 99-107. PMID: 18855800, PMCID: PMC2732001, DOI: 10.1111/j.1369-1600.2008.00135.x.Peer-Reviewed Original ResearchConceptsMedication screeningHuman laboratory modelSmoking behaviorMedication developmentSubsequent ad libitum smokingAd libitum smokingDrug Administration approvalSelf-administration sessionsMedication signalsCessation medicationsLapse behaviorAdministration approvalFirst cigaretteAbstinence outcomesQuit attemptsSmoking relapseUS FoodSmokingSmokersRelapseImportant targetTranslational workCigarettesScreeningMechanistic evaluation
2006
Modeling the effect of alcohol on smoking lapse behavior
McKee SA, Krishnan-Sarin S, Shi J, Mase T, O’Malley S. Modeling the effect of alcohol on smoking lapse behavior. Psychopharmacology 2006, 189: 201-210. PMID: 17013640, PMCID: PMC2862311, DOI: 10.1007/s00213-006-0551-8.Peer-Reviewed Original ResearchConceptsFirst cigaretteSelf-administration sessionsNovel human laboratory modelPoor smoking cessation outcomesSmoking cessation outcomesSmoking lapse behaviorHuman laboratory modelEffects of alcoholSecondary outcomesAlcohol drinkersLapse behaviorMore cigarettesNicotine withdrawalCessation outcomesRisk factorsDaily smokersSubsequent smokingTobacco cravingPlacebo beverageTobacco relapseSmoking sessionHeavy social drinkersPriming drinkAlcohol consumptionAlcohol use