2018
Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior
Verplaetse TL, Weinberger AH, Ashare RL, Pittman BP, Shi JM, Tetrault JM, Lavery M, McKee SA. Pilot investigation of the effect of carvedilol on stress-precipitated smoking-lapse behavior. Journal Of Psychopharmacology 2018, 32: 1003-1009. PMID: 29692206, PMCID: PMC6258014, DOI: 10.1177/0269881118767647.Peer-Reviewed Original ResearchConceptsEffects of carvedilolSmoking lapse behaviorAdrenergic antagonistsTobacco cravingSmoking outcomesPhysiologic reactivitySystolic blood pressureNumber of cigarettesNicotine-motivated behaviors× time effectSelf-administration periodEffects of α1Human laboratory modelNicotine-deprived smokersPlacebo groupBlood pressureAdrenergic antagonismMedication conditionClinical indicationsNoradrenergic systemSubsequent smokingHeart rateProperties of drugsSmokingCarvedilol
2017
Effect of doxazosin on stress reactivity and the ability to resist smoking
Verplaetse TL, Weinberger AH, Oberleitner LM, Smith KM, Pittman BP, Shi JM, Tetrault JM, Lavery ME, Picciotto MR, McKee SA. Effect of doxazosin on stress reactivity and the ability to resist smoking. Journal Of Psychopharmacology 2017, 31: 830-840. PMID: 28440105, PMCID: PMC5823502, DOI: 10.1177/0269881117699603.Peer-Reviewed Original ResearchConceptsTobacco cravingCortisol levelsSubsequent ad libitum smokingEffects of doxazosinAd libitum smokingNumber of cigarettesNicotine-motivated behaviorsSmoking lapse behaviorΑ1-adrenergic antagonistNicotine-deprived smokersTitration periodPreclinical findingsSmoking cessationNoradrenergic systemTreatment strategiesDoxazosinSmoking behaviorSmokingHuman laboratoryPhysiologic reactivityPilot studyStress reactivityEffects of stressCigarettesStress imagery
2011
Gender Differences in Smoking Following an Implicit Mood Induction
Weinberger AH, McKee SA. Gender Differences in Smoking Following an Implicit Mood Induction. Nicotine & Tobacco Research 2011, 14: 621-625. PMID: 21908458, PMCID: PMC3430446, DOI: 10.1093/ntr/ntr198.Peer-Reviewed Original ResearchConceptsNumber of cigarettesSmoking behaviorNegative mood inductionMood inductionFemale smokersNegative affectMood conditionGender differencesPositive mood inductionNeutral mood conditionAdult smokersSmoking maintenanceSmokersSmokingTreatment developmentMood manipulationNegative moodRole of genderInductionCigarettesLaboratory sessionsAffectDifferences
2009
Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study
McKee SA, Weinberger AH, Harrison EL, Coppola S, George TP. Effects of the nicotinic receptor antagonist mecamylamine on ad-lib smoking behavior, topography, and nicotine levels in smokers with and without schizophrenia: A preliminary study. Schizophrenia Research 2009, 115: 317-324. PMID: 19700263, PMCID: PMC2784178, DOI: 10.1016/j.schres.2009.07.019.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBehavior, AddictiveDouble-Blind MethodFemaleHumansMaleMecamylamineMiddle AgedNeuropsychological TestsNicotinic AntagonistsReaction TimeSchizophreniaSelf AdministrationSmokingSmoking CessationSubstance Withdrawal SyndromeSurveys and QuestionnairesTobacco Use DisorderYoung AdultConceptsAd lib smoking behaviorNicotine levelsSmoking behaviorControl smokersSmoking topographyNicotinic receptor antagonist mecamylamineNicotinic acetylcholine receptor antagonistHealthy control smokersHigh-affinity nAChRsIntensity of smokingAd lib smokingEffects of mecamylamineNumber of cigarettesPlacebo-controlled designAcetylcholine receptor antagonistNicotine exposureAntagonist mecamylamineCompensatory smokingReceptor antagonistSmoking intensityMecamylamineSmokersSmokingSchizophreniaPreliminary study