2018
Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes
Roberts W, McKee SA. Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes. Experimental And Clinical Psychopharmacology 2018, 26: 49-57. PMID: 29389170, PMCID: PMC5797996, DOI: 10.1037/pha0000161.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive functioningCognitive assessment batteryContinuous performance taskAdult heavy drinkersSignificant indirect effectUse disordersReaction timeEffects of vareniclinePerformance taskHeavy drinkersCognitive outcomesAssessment BatteryHuman laboratory experimentsCognitive functionMediation analysisDrinking outcomesMemoryLess drinkingAlcohol useDrinking behaviorIndirect effectsLaboratory sessionsDrinking taskVarenicline dose
2017
Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.Peer-Reviewed Original ResearchConceptsDepressive symptomsAlcohol cravingAlcohol useEffects of vareniclineRole of nAChRsHuman laboratory studiesDSM-IV criteriaSymptoms of depressionAlcohol use disorderLaboratory testing sessionsMore depressive symptomsMedication pretreatmentPlasma levelsPriming doseVareniclineUse disordersTreatment moderatorsAlcohol consumptionDepression symptomsHeavy drinkersAlcohol usersDrinking taskSymptomsLess drinkingDrinkers