2022
Modeling ability to resist alcohol in the human laboratory: A pilot study
Sloan M, Sells J, Vaughan C, Morris J, Ortega N, Sundar S, Soundararajan S, Stangl B, Gowin J, Chawla S, Diazgranados N, McKee S, Waters A, Ramchandani V. Modeling ability to resist alcohol in the human laboratory: A pilot study. Drug And Alcohol Dependence Reports 2022, 5: 100105. PMID: 36844167, PMCID: PMC9948911, DOI: 10.1016/j.dadr.2022.100105.Peer-Reviewed Original ResearchAlcohol self-administration paradigmSelf-administration paradigmCox proportional hazards regressionAlcohol usePilot studyLow-risk consumptionRisk of lapseHalf of patientsProportional hazards regressionSelf-administer alcoholAlcohol use disorderAlcohol intakeHazards regressionPriming doseUse disordersScale scoreHeavy drinkersHuman laboratoryImpaired controlInitial exposureCharacteristics of individualsPreliminary evidenceControl Scale scoresFuture studiesIndividuals
2020
A Critical Review of Alcohol Administration Guidelines in Laboratory Medication Screening Research: Is It Time to Include Treatment Seekers?
Roberts W, Verplaetse TL, Ramchandani VA, McKee SA. A Critical Review of Alcohol Administration Guidelines in Laboratory Medication Screening Research: Is It Time to Include Treatment Seekers? Alcohol Clinical And Experimental Research 2020, 45: 15-24. PMID: 33190310, PMCID: PMC7855436, DOI: 10.1111/acer.14514.Peer-Reviewed Original ResearchConceptsHuman laboratory studiesTreatment seekersNontreatment seekersExpensive clinical trialsPatient populationAlcohol administrationClinical trialsMedication effectsClinical conditionsMedication developmentMedicationsHeavy drinkersMedication experimentsLaboratory screeningClinical realityAdministration guidelinesScreening researchDevelopment pipelineLaboratory studiesRiskGuidelinesParticipantsPharmacotherapyPopulationEthical guidelines
2018
Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users
Roberts W, Shi JM, Tetrault JM, McKee SA. Effects of Varenicline Alone and in Combination With Low-dose Naltrexone on Alcohol-primed Smoking in Heavy-drinking Tobacco Users. Journal Of Addiction Medicine 2018, 12: 227-233. PMID: 29438157, PMCID: PMC5970035, DOI: 10.1097/adm.0000000000000392.Peer-Reviewed Original ResearchConceptsLow-dose naltrexoneTobacco usersTreatment outcomesPlacebo-controlled human laboratory studySmoking cessation treatmentEffects of vareniclineCigarettes ad libitumHuman laboratory studiesSubjective drug effectsVarenicline monotherapyCessation medicationsMedication therapyCessation treatmentMedication armTobacco useVareniclineLow doseSmoking relapseSmokingDrug effectsSmoking outcomesSmoking behaviorNaltrexoneCarbon monoxide levelsHeavy drinkersEffects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes
Roberts W, McKee SA. Effects of Varenicline on Cognitive Performance in Heavy Drinkers: Dose-Response Effects and Associations With Drinking Outcomes. Experimental And Clinical Psychopharmacology 2018, 26: 49-57. PMID: 29389170, PMCID: PMC5797996, DOI: 10.1037/pha0000161.Peer-Reviewed Original ResearchConceptsAlcohol use disorderCognitive functioningCognitive assessment batteryContinuous performance taskAdult heavy drinkersSignificant indirect effectUse disordersReaction timeEffects of vareniclinePerformance taskHeavy drinkersCognitive outcomesAssessment BatteryHuman laboratory experimentsCognitive functionMediation analysisDrinking outcomesMemoryLess drinkingAlcohol useDrinking behaviorIndirect effectsLaboratory sessionsDrinking taskVarenicline dose
2017
Effects of varenicline on alcohol cue reactivity in heavy drinkers
Roberts W, Harrison ELR, McKee SA. Effects of varenicline on alcohol cue reactivity in heavy drinkers. Psychopharmacology 2017, 234: 2737-2745. PMID: 28600734, PMCID: PMC5709183, DOI: 10.1007/s00213-017-4667-9.Peer-Reviewed Original ResearchConceptsEffects of vareniclineHuman laboratory studiesAlcohol use disorderAlcohol cue reactivityHeavy drinkersUse disordersPlacebo-controlled human laboratory studyCue exposureAlcohol useCue reactivityUse of vareniclineFront-line treatmentCue-induced alcohol cravingAlcohol cue exposureTitration periodCue-reactivity paradigmMedication groupPharmacological treatmentMedication effectsAdult smokersTobacco cravingVareniclineMethodsAs partLarge seriesAlcohol cravingEffects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms
Roberts W, Verplaetse TL, Moore K, Oberleitner L, Picciotto MR, McKee SA. Effects of varenicline on alcohol self-administration and craving in drinkers with depressive symptoms. Journal Of Psychopharmacology 2017, 31: 906-914. PMID: 28351203, PMCID: PMC5823265, DOI: 10.1177/0269881117699618.Peer-Reviewed Original ResearchConceptsDepressive symptomsAlcohol cravingAlcohol useEffects of vareniclineRole of nAChRsHuman laboratory studiesDSM-IV criteriaSymptoms of depressionAlcohol use disorderLaboratory testing sessionsMore depressive symptomsMedication pretreatmentPlasma levelsPriming doseVareniclineUse disordersTreatment moderatorsAlcohol consumptionDepression symptomsHeavy drinkersAlcohol usersDrinking taskSymptomsLess drinkingDrinkers
2015
The Yale Craving Scale: Development and psychometric properties
Rojewski AM, Morean ME, Toll BA, McKee SA, Krishnan-Sarin S, Green BG, Bartoshuk LM, O’Malley S. The Yale Craving Scale: Development and psychometric properties. Drug And Alcohol Dependence 2015, 154: 158-166. PMID: 26183404, PMCID: PMC4834029, DOI: 10.1016/j.drugalcdep.2015.06.040.Peer-Reviewed Original ResearchConceptsCeiling effectsPsychometric evaluationCraving ScaleDrinking scoresTreatment-seeking smokersInternal consistencyGood internal consistencyHeavy drinkersSmokingGroup comparisonsDrinking urgesStudy sampleDrinking outcomesSensation intensitySubjective cravingLabeled Magnitude ScaleCigarettesPsychometric propertiesScoresCurrent studyLatent factor structureTest-criterion relationshipsSound scaleSmokersDependent populationInfluence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration
Lechner WV, Knopik VS, McGeary JE, Spillane NS, Tidey JW, McKee SA, Metrik J, Leventhal AM, Rohsenow DJ, Kahler CW. Influence of the A118G Polymorphism of the OPRM1 Gene and Exon 3 VNTR Polymorphism of the DRD4 Gene on Cigarette Craving After Alcohol Administration. Nicotine & Tobacco Research 2015, 18: 632-636. PMID: 26092968, PMCID: PMC5896808, DOI: 10.1093/ntr/ntv136.Peer-Reviewed Original ResearchConceptsA118G polymorphismG polymorphismOPRM1 geneAlcohol administrationG carriersG alleleRepeated-measures design studyA118G genotypeG allele carriersDose of alcoholVNTR polymorphismMean age 39.2Greater increaseSmoking cessationAge 39.2Allele carriersCigarette cravingG genotypeHigh doseAlcohol consumptionHeavy drinkersThree-sessionDRD4 geneHeavy drinkingVNTR genotype
2010
SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals
Esterlis I, Cosgrove KP, Petrakis IL, McKee SA, Bois F, Krantzler E, Stiklus SM, Perry EB, Tamagnan GD, Seibyl JP, Krystal JH, Staley JK. SPECT imaging of nicotinic acetylcholine receptors in nonsmoking heavy alcohol drinking individuals. Drug And Alcohol Dependence 2010, 108: 146-150. PMID: 20074869, PMCID: PMC2871672, DOI: 10.1016/j.drugalcdep.2009.12.006.Peer-Reviewed Original ResearchConceptsDrinks/occasionNicotinic acetylcholine receptorsControl nonsmokersAcetylcholine receptorsHeavy drinkersHeavy drinkingLast alcoholic beverageHeavy alcohol drinkersHeavy alcoholSingle photon emissionSeverity of drinkingEffect of ageTobacco smokingAlcohol drinkersAlcohol drinkingCommon neural substrateNonsmokersAlcohol consumptionReceptor availabilityLarger studyAlcohol drinksAlcohol use behaviorsAddictive disordersDrinkersNeural substrates
2009
Longitudinal evaluation of smoke-free Scotland on pub and home drinking behavior: Findings from the International Tobacco Control Policy Evaluation Project
McKee SA, Higbee C, O'Malley S, Hassan L, Borland R, Cummings KM, Hastings G, Fong GT, Hyland A. Longitudinal evaluation of smoke-free Scotland on pub and home drinking behavior: Findings from the International Tobacco Control Policy Evaluation Project. Nicotine & Tobacco Research 2009, 11: 619-626. PMID: 19351787, PMCID: PMC2688599, DOI: 10.1093/ntr/ntp020.Peer-Reviewed Original ResearchConceptsSmoke-free policiesPolicy implementationUnited KingdomComprehensive smoke-free policiesInternational Tobacco Control Policy Evaluation ProjectPublic venuesHeavy drinkersDrinking behaviorAdditional public health benefitsAlcohol-related health problemsIndoor public venuesPolicySmoke-free legislationPublic health benefitsAdult smokersMean changeModerate drinkersSmokersHealth problemsLongitudinal evaluationGreater riskPubsScotlandLegislationStudy period
2007
Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration
McKee SA, O’Malley S, Shi J, Mase T, Krishnan-Sarin S. Effect of transdermal nicotine replacement on alcohol responses and alcohol self-administration. Psychopharmacology 2007, 196: 189-200. PMID: 17912500, PMCID: PMC2862181, DOI: 10.1007/s00213-007-0952-3.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, CutaneousAdultAlcohol DrinkingBlood PressureChromatography, High Pressure LiquidDose-Response Relationship, DrugDouble-Blind MethodDrinking BehaviorFemaleHeart RateHumansMaleMiddle AgedMonitoring, PhysiologicNicotineOscillometrySelf AdministrationSelf-AssessmentSkin TemperatureSmoking PreventionSpectrophotometry, UltravioletSurveys and QuestionnairesTime FactorsConceptsTransdermal nicotine replacementNicotine replacementSelf-administration periodPriming drinkHeavy drinkersPatch applicationNicotine deprivationAlcohol responsesNicotine patch conditionPlacebo patch conditionDouble-blind studySystolic blood pressureHeavy drinking smokersPatch conditionsAlcohol drinking behaviorTransdermal patch applicationDrinking behaviorInitiation of drinkingBlood pressurePlacebo patchAdditional drinkDaily smokersTobacco cravingTobacco useHeart rate