A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation
McKee SA, Potenza MN, Kober H, Sofuoglu M, Arnsten A, Picciotto MR, Weinberger AH, Ashare R, Sinha R. A translational investigation targeting stress-reactivity and prefrontal cognitive control with guanfacine for smoking cessation. Journal Of Psychopharmacology 2014, 29: 300-311. PMID: 25516371, PMCID: PMC4376109, DOI: 10.1177/0269881114562091.Peer-Reviewed Original ResearchConceptsPlacebo-treated subjectsFunctional magnetic resonance imagingCentral noradrenergic pathwaysPrefrontal cognitive dysfunctionSystolic blood pressureClinical outcome dataAd libitum smokingNovel translational approachStress-induced reinstatementMagnetic resonance imagingNicotine-deprived smokersBlood pressureNoradrenergic pathwaysAgonist guanfacineCognitive dysfunctionTreatment periodTobacco cravingQuit attemptsOutcome dataSmokingComplete abstinenceCortisol levelsTranslational investigationsCigarette useGuanfacineWeak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking
Wilson SJ, Delgado MR, McKee SA, Grigson PS, MacLean RR, Nichols TT, Henry SL. Weak ventral striatal responses to monetary outcomes predict an unwillingness to resist cigarette smoking. Cognitive, Affective, & Behavioral Neuroscience 2014, 14: 1196-1207. PMID: 24777394, PMCID: PMC4213351, DOI: 10.3758/s13415-014-0285-8.Peer-Reviewed Original ResearchConceptsNicotine-deprived smokersIndividual differencesNondrug rewardsMonetary outcomesVentral striatumReward-related brain activityMeaningful individual differencesFunctional magnetic resonance imagingReward-motivated behaviorsLarge individual differencesVentral striatal responsePoor smoking cessation outcomesSmoking cessation outcomesNondrug incentivesReward devaluationNeural responsesStriatal responsesNeurobiological mechanismsBrain activityNeurobiological responsesCessation outcomesRewardMonetary reinforcementIndividual variabilityClinical implications