2004
Disruption of Ixodes scapularis anticoagulation by using RNA interference
Narasimhan S, Montgomery RR, DePonte K, Tschudi C, Marcantonio N, Anderson JF, Sauer JR, Cappello M, Kantor FS, Fikrig E. Disruption of Ixodes scapularis anticoagulation by using RNA interference. Proceedings Of The National Academy Of Sciences Of The United States Of America 2004, 101: 1141-1146. PMID: 14745044, PMCID: PMC337020, DOI: 10.1073/pnas.0307669100.Peer-Reviewed Original ResearchConceptsAnti-factor Xa activityNumerous infectious diseasesIxodes scapularis ticksRNA interferenceMultiple anticoagulantsReduction of mRNAXa activityVaccine candidatesInfectious diseasesTick salivaAnticoagulantsBabesia microtiPhysiologic functionI. scapularis salivaSalivary glandsBorrelia burgdorferiTick feedingScapularis ticksAnticoagulant activityAnaplasma phagocytophilumTick engorgementSuch interventionsEngorgement weightEngorgementKey target
1986
Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein.
Montgomery RR, Nathan CF, Cohn ZA. Effects of reagent and cell-generated hydrogen peroxide on the properties of low density lipoprotein. Proceedings Of The National Academy Of Sciences Of The United States Of America 1986, 83: 6631-6635. PMID: 3018740, PMCID: PMC386558, DOI: 10.1073/pnas.83.17.6631.Peer-Reviewed Original ResearchConceptsLow-density lipoproteinDensity lipoproteinHuman monocytesModification of LDLUntreated low-density lipoproteinOxidation of LDLThiobarbituric acidAortic endothelial cell linePhorbol myristate acetateEndothelial cell lineReactive oxygen intermediatesCell line monolayersRespiratory burstMyristate acetateMacrophagesMouse macrophagesReagent H2O2Cell linesOxygen intermediatesMonocytesLipoproteinTBA reactivityHuman plasmaMaximal oxidation