2019
Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry
Carvajal-Hausdorf DE, Patsenker J, Stanton KP, Villarroel-Espindola F, Esch A, Montgomery RR, Psyrri A, Kalogeras KT, Kotoula V, Foutzilas G, Schalper KA, Kluger Y, Rimm DL. Multiplexed (18-Plex) Measurement of Signaling Targets and Cytotoxic T Cells in Trastuzumab-Treated Patients using Imaging Mass Cytometry. Clinical Cancer Research 2019, 25: 3054-3062. PMID: 30796036, PMCID: PMC6522272, DOI: 10.1158/1078-0432.ccr-18-2599.Peer-Reviewed Original ResearchConceptsTrastuzumab-treated patientsT cell infiltrationCD8 T cell infiltrationCohort of patientsCytotoxic T cellsMass cytometryCase-control seriesExtracellular domainMechanism of actionTrastuzumab benefitAdjuvant treatmentCD8 cellsRecurrence eventsT cellsAntibody panelImmune systemPatientsMetal-conjugated antibodiesQuantitative immunofluorescenceTrastuzumabImaging Mass CytometryHER2Signaling targetsObjective measurementsCytometry
2015
Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis
Das R, Loughran K, Murchison C, Qian F, Leng L, Song Y, Montgomery RR, Loeb M, Bucala R. Association between high expression macrophage migration inhibitory factor (MIF) alleles and West Nile virus encephalitis. Cytokine 2015, 78: 51-54. PMID: 26638028, PMCID: PMC4696904, DOI: 10.1016/j.cyto.2015.11.021.Peer-Reviewed Original ResearchConceptsMacrophage migration inhibitory factorWNV encephalitisWest Nile virusHigh-expression MIF allelesWest Nile virus encephalitisNeuroinvasive WNV diseaseCase-control studyMigration inhibitory factorNorth American patientsMIF locusWNV neuropathogenesisVirus encephalitisViral neuroinvasionInnate cytokinesMIF allelesAmerican patientsTherapeutic targetAnimal modelsWNV diseaseEncephalitisInhibitory factorFunctional polymorphismsPatientsNile virusImportant determinant
2013
Cytokine Response Signatures in Disease Progression and Development of Severe Clinical Outcomes for Leptospirosis
Reis EA, Hagan JE, Ribeiro GS, Teixeira-Carvalho A, Martins-Filho OA, Montgomery RR, Shaw AC, Ko AI, Reis MG. Cytokine Response Signatures in Disease Progression and Development of Severe Clinical Outcomes for Leptospirosis. PLOS Neglected Tropical Diseases 2013, 7: e2457. PMID: 24069500, PMCID: PMC3777885, DOI: 10.1371/journal.pntd.0002457.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiomarkersCase-Control StudiesCytokinesDisease ProgressionFemaleHumansLeptospirosisMaleMiddle AgedSurvival AnalysisYoung AdultConceptsSevere pulmonary hemorrhage syndromeIL-10IL-6Mild diseaseClinical outcomesIL-8Disease progressionSevere diseaseSerum cytokine responseDays of symptomsHospital-based surveillanceAnti-inflammatory cytokinesIL-6 levelsCase-control study designPulmonary hemorrhage syndromeSevere clinical outcomesMultiplex bead array assayNon-fatal casesLife-threatening outcomesBead array assayImmunopathogenic roleCytokine profileCytokine stormIL-17ANonfatal outcomes
2011
Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus
Sreih A, Ezzeddine R, Leng L, LaChance A, Yu G, Mizue Y, Subrahmanyan L, Pons‐Estel B, Abelson A, Gunnarsson I, Svenungsson E, Cavett J, Glenn S, Zhang L, Montgomery R, Perl A, Salmon J, Alarcón‐Riquelme M, Harley JB, Bucala R. Dual effect of the macrophage migration inhibitory factor gene on the development and severity of human systemic lupus erythematosus. Arthritis & Rheumatism 2011, 63: 3942-3951. PMID: 22127710, PMCID: PMC3228269, DOI: 10.1002/art.30624.Peer-Reviewed Original ResearchMeSH KeywordsAdultBlack or African AmericanCase-Control StudiesCross-Sectional StudiesFemaleGenetic Predisposition to DiseaseGenotypeHumansLupus Erythematosus, SystemicMacrophage Migration-Inhibitory FactorsMaleMiddle AgedPhenotypePolymorphism, Single NucleotideSeverity of Illness IndexTumor Necrosis Factor-alphaWhite PeopleConceptsSystemic lupus erythematosusMacrophage migration inhibitory factorMIF genotypeMIF productionLupus erythematosusImmunopathogenesis of SLEInflammatory end-organ damageCentral nervous system involvementCytokine macrophage migration inhibitory factorToll-like receptor 7Human systemic lupus erythematosusMacrophage migration inhibitory factor geneMIF plasma levelsPlasma MIF levelsEnd-organ damageNervous system involvementEnd-organ involvementAfrican American patientsMigration inhibitory factorMIF levelsProinflammatory propertiesPlasma levelsReceptor 7System involvementAmerican patients