2019
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs. 2019, 1241-1258. DOI: 10.1007/978-3-319-99375-1_109.Peer-Reviewed Original ResearchCellular stress responseNumerous biological processesUnderstanding of immunosenescenceCellular proteinsNoncoding RNAsGenomic instabilityReactive oxygen speciesCellular agingBiological processesStress responseAging pathwaysImportant regulatorDNA damageMitochondrial dysfunctionCellular mechanismsInefficient autophagyOxidative damageOxygen speciesRNAFundamental roleRecent studiesMechanisms of immunosenescenceImmune regulationNcRNAsAccumulation
2017
Age-Related Changes in Immune Regulation by Noncoding RNAs
Wang W, Qian F, Montgomery R. Age-Related Changes in Immune Regulation by Noncoding RNAs. 2017, 1-18. DOI: 10.1007/978-3-319-64597-1_109-1.Peer-Reviewed Original ResearchCellular stress responseNumerous biological processesUnderstanding of immunosenescenceCellular proteinsNoncoding RNAsGenomic instabilityReactive oxygen speciesCellular agingBiological processesStress responseAging pathwaysImportant regulatorDNA damageMitochondrial dysfunctionCellular mechanismsInefficient autophagyOxidative damageOxygen speciesRNAFundamental roleRecent studiesMechanisms of immunosenescenceImmune regulationNcRNAsAccumulation
2014
Effect of aging on microRNAs and regulation of pathogen recognition receptors
Olivieri F, Procopio AD, Montgomery RR. Effect of aging on microRNAs and regulation of pathogen recognition receptors. Current Opinion In Immunology 2014, 29: 29-37. PMID: 24769423, PMCID: PMC4119513, DOI: 10.1016/j.coi.2014.03.006.Peer-Reviewed Original ResearchConceptsInnate immune recognitionImmune innate responseResolution of inflammationPathogen recognition receptorsTLR signalsUnderstanding of immunosenescenceProinflammatory responseImmune responseNF-κBInnate responseImmune recognitionRecognition receptorsActive investigationImmunosenescenceDownstream effectorsRecent studiesNegative regulatorSimilar regulatory activitiesResponseMiRNAsInflammationMicroRNAsAging-associated miRNAsVaccine
2010
Dysregulation of human Toll-like receptor function in aging
Shaw AC, Panda A, Joshi SR, Qian F, Allore HG, Montgomery RR. Dysregulation of human Toll-like receptor function in aging. Ageing Research Reviews 2010, 10: 346-353. PMID: 21074638, PMCID: PMC3633557, DOI: 10.1016/j.arr.2010.10.007.Peer-Reviewed Original ResearchConceptsToll-like receptorsTLR functionImmune systemToll-like receptor functionPattern recognition receptor familyAge-associated dysregulationInnate immune systemGeriatric patientsTLR activationAnimal modelsContext of agingReceptor functionHuman cohortsInfectious diseasesReceptor familyInappropriate persistenceDysregulationRecent studiesOverarching themesAdaptive responseMorbidityImmunosenescencePatientsCohortInnate