Humanized mouse model supports development, function, and tissue residency of human natural killer cells
Herndler-Brandstetter D, Shan L, Yao Y, Stecher C, Plajer V, Lietzenmayer M, Strowig T, de Zoete MR, Palm NW, Chen J, Blish CA, Frleta D, Gurer C, Macdonald LE, Murphy AJ, Yancopoulos GD, Montgomery RR, Flavell RA. Humanized mouse model supports development, function, and tissue residency of human natural killer cells. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e9626-e9634. PMID: 29078283, PMCID: PMC5692533, DOI: 10.1073/pnas.1705301114.Peer-Reviewed Original ResearchConceptsHuman natural killer cellsNatural killer cellsHumanized mouse modelCell subsetsKiller cellsLymphoma xenograftsHuman NKMouse modelHuman antitumor immune responsesHuman NK cell subsetsInnate lymphoid cell subsetsBurkitt's lymphoma xenograftsNK cell subpopulationsNK cell subsetsAntitumor immune responseT cell subsetsHuman NK cellsKiller inhibitory receptorsLymphoid cell subsetsSignal regulatory protein alphaHuman immune systemHuman interleukin-15Regulatory protein alphaNK cellsHumanized miceThe natural killer cell response to West Nile virus in young and old individuals with or without a prior history of infection
Yao Y, Strauss-Albee DM, Zhou JQ, Malawista A, Garcia MN, Murray KO, Blish CA, Montgomery RR. The natural killer cell response to West Nile virus in young and old individuals with or without a prior history of infection. PLOS ONE 2017, 12: e0172625. PMID: 28235099, PMCID: PMC5325267, DOI: 10.1371/journal.pone.0172625.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedAged, 80 and overAntigens, CDAsymptomatic DiseasesFemaleGene Expression RegulationHumansImmunity, InnateImmunophenotypingInterferon-gammaKiller Cells, NaturalLymphocyte ActivationLymphocyte CountMiddle AgedNatural Cytotoxicity Triggering Receptor 1Natural Cytotoxicity Triggering Receptor 2Natural Cytotoxicity Triggering Receptor 3NK Cell Lectin-Like Receptor Subfamily CNK Cell Lectin-Like Receptor Subfamily KPrimary Cell CultureSeverity of Illness IndexWest Nile FeverWest Nile virusConceptsNK cell subsetsNK cellsWest Nile virusWNV infectionCell subsetsCell responsesSpecific NK cell subsetsNatural killer cell responsesInnate NK cellsSevere neuroinvasive diseaseNK cell responsesNK cell receptorsNile virusHuman WNV infectionsImmune pathogenesisNK repertoirePolyfunctional responsesMore IFNSymptomatic infectionChemokine secretionAsymptomatic infectionNeuroinvasive diseasePrior historyCytolytic activityInfection