2005
Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development
Koukouritaki S, Hines R. Flavin-containing monooxygenase genetic polymorphism: impact on chemical metabolism and drug development. Pharmacogenomics 2005, 6: 807-822. PMID: 16296944, DOI: 10.2217/14622416.6.8.807.Peer-Reviewed Original Research
2004
DIFFERENCES IN FMO2*1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT
Krueger S, Siddens L, Martin S, Yu Z, Pereira C, Cabacungan E, Hines R, Ardlie K, Raucy J, Williams D. DIFFERENCES IN FMO2*1 ALLELIC FREQUENCY BETWEEN HISPANICS OF PUERTO RICAN AND MEXICAN DESCENT. Drug Metabolism And Disposition 2004, 32: 1337-1340. PMID: 15355885, DOI: 10.1124/dmd.104.001099.Peer-Reviewed Original Research
2002
Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression
Koukouritaki S, Simpson P, Yeung C, Rettie A, Hines R. Human Hepatic Flavin-Containing Monooxygenases 1 (FMO1) and 3 (FMO3) Developmental Expression. Pediatric Research 2002, 51: 236-243. PMID: 11809920, DOI: 10.1203/00006450-200202000-00018.Peer-Reviewed Original ResearchConceptsFlavin-containing monooxygenasesExpression patternsSpecies-specific expression patternsFMO3 expressionTemporal expression patternsMajor adult isoformFMO genesPotential control mechanismsDevelopmental expressionProtein levelsAdult isoformsWestern blottingExpressionEmbryosNumerous therapeuticsIsoformsMonooxygenases 1Most individualsFMO3Microsomal fractionHuman liver samplesIntermediate levelsControl mechanismsGenesPrecise timingGENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO)
Krueger S, Williams D, Yueh M, Martin S, Hines R, Raucy J, Dolphin C, Shephard E, Phillips I. GENETIC POLYMORPHISMS OF FLAVIN-CONTAINING MONOOXYGENASE (FMO). Drug Metabolism Reviews 2002, 34: 523-532. PMID: 12214664, DOI: 10.1081/dmr-120005653.Peer-Reviewed Original ResearchConceptsFlavin-Containing MonooxygenaseAdult human liverPercent of individualsPlethora of drugsTrimethylamine N-oxygenationDrug metabolismHuman liverGenetic polymorphismsHispanic descentPremature stop codonPolymorphic expressionLungPreliminary evidenceFunctional FMO2African descentXenobiotic toxicityMammalian flavinN-oxygenationFMO2TrimethylaminuriaEthylene thioureaPolymorphismAllelesPatientsExpression
1999
Flavin‐containing monooxygenase isoform 2: Developmental expression in fetal and neonatal rabbit lung
Larsen‐Su S, Krueger S, Yueh M, Lee M, Shehin S, Hines R, Williams D. Flavin‐containing monooxygenase isoform 2: Developmental expression in fetal and neonatal rabbit lung. Journal Of Biochemical And Molecular Toxicology 1999, 13: 187-193. PMID: 10098904, DOI: 10.1002/(sici)1099-0461(1999)13:3/4<187::aid-jbt9>3.0.co;2-6.Peer-Reviewed Original ResearchConceptsEarly developmental appearanceRabbit lungsNeonatal rabbit lungConstitutive cytochrome P450Developmental appearanceNeonatal lungToxic insultsLungMonooxygenase isoformsNumerous xenobioticsForeign chemicalsMonooxygenase functionCytochrome P450Major isoformsTissue-specific fashionDevelopmental expressionMammalian flavinIsoform 2Expression patternsIsoformsFMO2Individual isoformsNeonatesFetuses
1995
Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.)
Peters L, Livingstone D, Shenin-Johnson S, Hines R, Schlenk D. Characterization of hepatic flavin monooxygenase from the marine teleost turbot (Scophthalmus maximus L.). Xenobiotica 1995, 25: 121-131. PMID: 7618340, DOI: 10.3109/00498259509061838.Peer-Reviewed Original ResearchConceptsFlavin monooxygenaseNADPH-dependent flavin monooxygenaseFMO-1Full-length cDNA probeFMO-2TMA N-oxideGene expressionMarine teleostsMature fishNorthern analysisCDNA probeXenobiotic metabolismDMA N-oxideImmunoreactive proteinOsmoregulationConversion of trimethylamineN-oxidase activityMonooxygenaseMichaelis-Menten kineticsSingle bandTurbotPiperonyl butoxideTeleostsFishProtein
1994
A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities
Lawton M, Cashman J, Cresteil T, Dolphin C, Elfarra A, Hines R, Hodgson E, Kimura T, Ozols J, Phillips I, Philpot R, Poulsen L, Rettie A, Shephard E, Williams D, Ziegler D. A Nomenclature for the Mammalian Flavin-Containing Monooxygenase Gene Family Based on Amino Acid Sequence Identities. Archives Of Biochemistry And Biophysics 1994, 308: 254-257. PMID: 8311461, DOI: 10.1006/abbi.1994.1035.Peer-Reviewed Original ResearchConceptsAmino acid sequenceGene familyAcid sequenceMammalian FMOsMammalian flavinFMO gene familySingle gene familyGene designationIndividual genesOrthologous formsPercentage identitySpecies linesGenesEnzymeFlavinSequenceFMO4FamilyUnambiguous identificationRelated formsFMO1OrthologsFMO2FMO3Nomenclature
1993
Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector
States J, Quan T, Hines R, Novak R, Runge-Morris M. Expression of human cytochrome P450 1A1 in DNA repair deficient and proficient human fibroblasts stably transformed with an inducible expression vector. Carcinogenesis 1993, 14: 1643-1649. PMID: 8353849, DOI: 10.1093/carcin/14.8.1643.Peer-Reviewed Original ResearchMeSH Keywords7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxideAnimalsBase SequenceBenzo(a)pyreneBenzoflavonesBiotransformationCadmiumCadmium CompoundsChimeraCytochrome P-450 Enzyme SystemDNA RepairEnzyme InductionFibroblastsGene Expression Regulation, EnzymologicGenetic VectorsHumansIsoenzymesMiceMolecular Sequence DataPlasmidsRNA, MessengerSulfatesTransfectionTransformation, GeneticXeroderma PigmentosumConceptsCytochrome P450 1A1P450 1A1Inducible CYP1A1Inducible mouse metallothionein-I promoterLow dosesHuman skin fibroblastsProficient cellsPotent mutagenic agentCYP1A1 expressionCYP1A1 activityHuman cytochrome P450 1A1DNA repairCYP1A1Mouse metallothionein-I promoterCytotoxic effectsMetallothionein-I promoterSkin fibroblastsDifferential cytotoxicityDNA repair-proficient cellsToxic effectsMore cytotoxicCytochrome P450Normal cellsRepairHuman CYP1A1
1990
Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas
McLemore T, Adelberg S, Liu M, McMahon N, Yu S, Hubbard W, Czerwinski M, Wood T, Storeng R, Lubet R, Eggleston J, Boyd M, Hines R. Expression of CYP1A1 Gene in Patients With Lung Cancer: Evidence for Cigarette Smoke-Induced Gene Expression in Normal Lung Tissue and for Altered Gene Regulation in Primary Pulmonary Carcinomas. Journal Of The National Cancer Institute 1990, 82: 1333-1339. PMID: 2380990, DOI: 10.1093/jnci/82.16.1333.Peer-Reviewed Original ResearchConceptsNormal lung tissuesLung tissueLung cancerFormer smokersCigarette smokersCYP1A1 gene expressionCYP1A1 geneActive cigarette smokersPrimary pulmonary carcinomasHuman pulmonary tissueMessenger RNA expressionPulmonary carcinogenesisCigarette smokingPulmonary carcinomaTime-dependent decreasePulmonary tissueGene expressionSmokersCarcinoma tissuesPatientsCancerTumorsRNA expressionMRNA levelsCYP1A1 mRNA